controlled release of insitu forming moxifloxacin and ketorolac hydrogel for ophthalmic drug delivery

1. welcome

3. • To formulate and evaluate hydrogel of
moxifloxain & ketorolac in view of
increasing precorneal residence time &
bioavailability of drugs
• Ion sensitive (sodium alginate), temperature
sensitive ( poloxamer)
• HPMC as viscosity enhancing agent.

4. 1)Literature survey
2)Collection of drugs, polymers & other
exicipents.
3)Standardization of drugs
4)Formulation development

5. A. Preformulation studies
Identification
1) Determination of melting point
2) Solubility – water ,ethanol, acetone,2-propanol
3) IR spectroscopy- comparison of sample with
standard
4) Compatibility study
B.Selection of vehicle
C.Formulation optimization by factorial design
D.Methods for in situ hydrogel preparation

6. • Moxifloxacin
• Ketorolac • Electronic balance
• Sodium alginate • Magentic stirrer
• Poloxamer • Digital pH meter
• HPMC • Brookfield viscometer
• Sodium hydroxide • UV-visible spectrophotometer
• Hydrochloric acid • Autoclave
• Potassium dihydrogen phosphate • Incubator
• Disodium hydrogen phosphate • Open end tube
• Glacial acetic acid • FI-IR spectrometer
• Ammonium acetate
• Citric acid monohydrate

7. Optimization by factorial design
Gelling Sl no Formulation Variable level Actual
agent code in coded form units
X1 X2 X1 X2(%w/v)
(%w/v)
Sodium 1 F1 -1 +1 1 1.0
alginate
2 F2 +1 -1 3 0.5
3 F3 -1 -1 1 0.5
4 F4 +1 +1 3 1.0
poloxamer 5 F5 -1 +1 15 1.0
6 F6 +1 -1 25 0.5
7 F7 -1 -1 15 0.5
8 F8 +1 +1 25 1.0

8. D. Evaluation parameters
 Appearance
 pH
 Invitro gelation studies
 Rheological studies
 Drug content
 In vitro release studies
 Sterility
 Ocular irritation studies
 Stability studies

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11. Thank you