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ARTIFICIAL SKIN
FOUNTA DIMITRA 994, KATRITZIDAKI THEODOSIA 1021
DEPARTMENT OF MATERIALS SCIENCE AND TECHNOLOGY| UNIVERSITY OF CRETE
DATE: 08/03/2017
WHAT IS ARTIFICIAL SKIN;
 The term artificial skin is used to describe every materials
that are used in order to replace (either temporarily or
permanent)and that it can be able to mimic the dermis
and epidermis layers of the skin.
Biobrane® : Temporary use Skin Graft : Permanent use
HISTORICAL BACKROUND
 1970 J.Burke και I.Yannas
 They synthesized a polymer from collagen fibers(fig.1) and
polysaccharides in order to create a porous material that
simulated the human skin , Silastic (fig.2)
 1979 first time on human
Figure 1 Figure 2
CATEGORIES – BIOLOGICAL
(+) Plenty amount, low cost
(+) more natural dermis layer
(-) Slow graft vasculature
 Cadaveric skin allograft
 Porcine skin allograft
(Xenograft)
 Amnion Amnion
CATEGORIES - SYNTHETIC
(+) Stable, biodegradable and suitable for tissue
regeneration
(+) Easy composition and control
of its properties
(+) Avoiding complications from
disease transfers
(-) no basement membrane
(-) Their architecture does not
look like normal skin
(-) Risk of graft rejection
 Dermagraft® (polyglactin mesh seeded with fibroblast)
 Integra® (bodine collagen , chondroitin-6-sulphate and silastic membrane)
 Biobrane® (nylon mesh, silastic membrane)
OTHER APPLICATIONS
 Overlap of prosthetic limbs
 Skin regeneration (cosmetology)
(MIT)
REFERENCES - LITERATURE
 http://www.woundcarecenters.org/article/wound-therapies/skin-substitutes
 https://www.slideshare.net/FelixObi/artificial-skin-and-artificial-cartilage
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038402
 http://www.cnn.gr/money/tech/story/31798/texnito-derma-i-apantisi-toy-mit-stis-rytides
 http://www.farmaluk.com/prod/14/2/n/26/BIOBRANE
 http://www.slate.com/articles/video/video/2016/01/ioannis_yannas_looks_back_wistfully_on_t
he_surprising_discovery_of_artificial.html
 http://www.wisegeek.com/what-is-artificial-skin.htm
 http://www.discoveriesinmedicine.com/Apg-Ban/Artificial-Skin.html
 https://www.hindawi.com/journals/bmri/2013/179784/
 http://www.ibtimes.com.au/polymer-stretches-senses-real-skin-1398122
Artificial Skin

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Artificial Skin

  • 1. ARTIFICIAL SKIN FOUNTA DIMITRA 994, KATRITZIDAKI THEODOSIA 1021 DEPARTMENT OF MATERIALS SCIENCE AND TECHNOLOGY| UNIVERSITY OF CRETE DATE: 08/03/2017
  • 2. WHAT IS ARTIFICIAL SKIN;  The term artificial skin is used to describe every materials that are used in order to replace (either temporarily or permanent)and that it can be able to mimic the dermis and epidermis layers of the skin. Biobrane® : Temporary use Skin Graft : Permanent use
  • 3. HISTORICAL BACKROUND  1970 J.Burke και I.Yannas  They synthesized a polymer from collagen fibers(fig.1) and polysaccharides in order to create a porous material that simulated the human skin , Silastic (fig.2)  1979 first time on human Figure 1 Figure 2
  • 4. CATEGORIES – BIOLOGICAL (+) Plenty amount, low cost (+) more natural dermis layer (-) Slow graft vasculature  Cadaveric skin allograft  Porcine skin allograft (Xenograft)  Amnion Amnion
  • 5. CATEGORIES - SYNTHETIC (+) Stable, biodegradable and suitable for tissue regeneration (+) Easy composition and control of its properties (+) Avoiding complications from disease transfers (-) no basement membrane (-) Their architecture does not look like normal skin (-) Risk of graft rejection  Dermagraft® (polyglactin mesh seeded with fibroblast)  Integra® (bodine collagen , chondroitin-6-sulphate and silastic membrane)  Biobrane® (nylon mesh, silastic membrane)
  • 6. OTHER APPLICATIONS  Overlap of prosthetic limbs  Skin regeneration (cosmetology) (MIT)
  • 7. REFERENCES - LITERATURE  http://www.woundcarecenters.org/article/wound-therapies/skin-substitutes  https://www.slideshare.net/FelixObi/artificial-skin-and-artificial-cartilage  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038402  http://www.cnn.gr/money/tech/story/31798/texnito-derma-i-apantisi-toy-mit-stis-rytides  http://www.farmaluk.com/prod/14/2/n/26/BIOBRANE  http://www.slate.com/articles/video/video/2016/01/ioannis_yannas_looks_back_wistfully_on_t he_surprising_discovery_of_artificial.html  http://www.wisegeek.com/what-is-artificial-skin.htm  http://www.discoveriesinmedicine.com/Apg-Ban/Artificial-Skin.html  https://www.hindawi.com/journals/bmri/2013/179784/  http://www.ibtimes.com.au/polymer-stretches-senses-real-skin-1398122