This document summarizes Dr. Arlan Andrews' presentation on entrepreneurship and science fictional thinking at the SIGMA forum in 2012. It discusses how entrepreneurs want to bring and own change, and how new disruptive technologies provide opportunities to do so. Science fictional thinking involves thinking without limits by recognizing trends and considering new paradigms informed by science and history. Examples are provided of evolutionary technologies like digital tattoos and neural interfaces, as well as potentially disruptive discoveries like evidence of alien life or faster-than-light travel.