1) The study evaluated the antidepressant activity of the ethanolic extract of Ocimum sanctum (tulsi) leaves in mice. 2) In the forced swim test, Ocimum sanctum showed significant antidepressant activity at a dose of 8.5 mg/kg compared to the control. 3) The study indicates the potential antidepressant-like effects of Ocimum sanctum, though the exact mechanism is still unknown. Further research is needed to elucidate the mechanism of action.