This document discusses depression and potential herbal treatments. It focuses on Moringa oleifera and its use for treating depression. Key points include: - Depression affects mood, motivation, and physical/mental functioning. It can impact family, work, health. - Causes include low neurotransmitters, oxidative stress, biochemical imbalance. It is treated with drugs, therapy, or herbal medicines. - M. oleifera is a highly valued medicinal plant known as the "miracle tree." It grows in tropical areas and all parts have medicinal properties. Previous research found it has anti-tumor, anti-inflammatory effects and more. - The document examines M. oleifera extracts for phytochem

1. BY SREEREMYA.S
M.phil

2. INTRODUCTION
 Depression is a widespread psychiatric disorder that
effect several millions of the world population.
 Recognized to be symptomatically, psychologically & biologically
heterogeneous .
 The disorder is characterized by change in mood, lack of interest in the
surroundings, lack of motivation, feelings of gloominess,retardation of
thinking and activity , sense of hopelessness , lack of physical energy
and despair and suicidal ideation etc……..
 Major depressive disorder is a disability condition that adversely affects a
person’s family , work or school life , sleeping & eating habit& general
health.

3. CONTI…………
 The major causes are decrease in the neurotransmitter level in
the brain , oxidative stress and biochemical imbalance etc…….
 Depression may treated with antidepressent medication ,
psychotherapy , self neglect ,etc………
 Both synthetic drugs (imipramine & diazepam) and herbal drugs
are used for antidepression treatments. in them herbal drugs are
more preferable because of less side effects & wider safety
margin .
 Works have been done on several medicinal plants like citrus maxima
leaves , Artemisia absinthium , Passiflora foetida leaves etc……..

4. Moringa oleifera

5. Conti………
 Moringa Oleifera is a highly valued medicinal plant
which is also known as “miracle tree”.
 It is most widely cultivated species & it’s grown mainly
in semi arid ,tropical & sub tropical areas.
 Flower , root , leaves , gum , bark , fruits , seeds are also
have medicinal values.

6. Conti……….
 several researches have already done in moringa which are anti tumer
, anti ulser , anti inflamatory , antiepileptic , anti bacterial , antifungal , anti
hepatoprotective , cholestrol lowering , anti alzheimer’s etc……
 Different part of this plant contain important minerals , vitamins ,mode
of sleeping power, beta-carotene in addition to it’s compelling water
purifying power & high nutritional values.

7. Conti…..
Phytochemical assays
1 Test for total phenolic content
2 Test for flavonoid content
3 Alkaloids
4 Tannins
5 Resin
6 Carbohydrate
7 Steroids & steroid
8 Saponin
9 Terpanoid
10 Glycoside .

8. Conti…..
 Anti oxidant studies
1, DPPH radical –scavinging activity
2, FRAP(Ferric radical scavenging activity)
3, SO2 (Super oxide scavinging activity)
4, nitric oxide scavinging activity

9. Conti…….
Behavioral test
 Tail suspention test
 Forced swimming test
 Open field test

10. Conti…..
 Evaluate the neurotransmitter level in mice
brain
 Noradrenaline level
 Serotonin level

11. WORKDONE
Prepared extract
 The powderd sample was extracted using
soxhlet method in ethanol .