This document provides a classification of different types of antibiotics based on their mechanism of action and includes: 1. Cell wall synthesis inhibitors like beta-lactams (penicillins and cephalosporins) and carbapenems that inhibit peptidoglycan synthesis. 2. Protein synthesis inhibitors that target the 30S ribosomal subunit (aminoglycosides), 50S ribosomal subunit (oxazolidinones, streptogramins), or are macrolides. 3. Agents that target DNA and DNA synthesis pathways including fluoroquinolones, sulfonamides, DHFR inhibitors, and those that cause DNA damage.

1. MOA (Inhibit) CLASSIFICATION ANTIBIOTICS
Cell Wall
Synthesis
Beta
Lactams Penicillin
Penicillinase-Sensible
Natural Penicillins
(Narrow Spectrum)
Penicillin G: Na, K, Procaine
Benzathine(IV,IM)
Penicillin V: VO
AminoPenicillins
(Broad Spectrum)
Ampicillin
Amoxicillin
Penicillinase-Resistant (Very Narrow Spectrum)
Nafcillin Oxacillin Dicloxacillin
Antipseudomonal (Extended Spectrum)
CarboxiPenicillins
Ticarcilllin
Carbenicillin
UreidoPenicillinn
Piperacillin
Azlocillin
Mezlocillin
Cephalosporin
1st
GEN
Cefazolin Cephalexine Cephapirin
Cefadroxil Cephadrine Cephalotin
2ND
GEN
Cefuroxime Cefamandole Cefprozil
Cefoxitin Cefonicid Cefmetazole
Cefotetan Cefaclor
3RD
GEN
Cefoperazone Ceftriaxone Ceftazidime
Cefpodoxime Ceftizioxime Cefotaxime
Cefdinir Ceftibuten Cefixime
Cefditoren
4TH
GEN
Cefepime Cefipirome
5TH
GEN
Ceftaroline
Carbapenem
Meropenem Ertapenem
Doripenem
Imipenem
+
Cylastatine
Monobactam Aztreonam
Beta Lactamase
Inhibitor
Sulbactam Tazobactam Clavulanic acid
No
Lactam
Glycopeptides
Vancomycin Bacitarcin
Teicoplanin Polymyxin B

2. Protein Synthesis
30s
Aminoglycoside
Gentamycin Neomycin Streptomycin
Amikacin Tobramycin
Tetracycline
Doxycycline Demeclocycline Minocycline
Tetracyclin Tigecyclin
50s
Oxazolidonones Linezolid
Streptogramins Quinopristin/ Dalfopristin
Chloramphenicol
Macrolides Erythromycin Azithromycin Claritrhomycin
Lincosamide Clindamycin Lincomycin
DNA
Topoisomerase
Fluoroquinolone
Ciprofloxacin Norfloxacin Levofloxacin Ofloxacin
Sparfloxacin Moxifloxacilin Gemifloxacin Enofloxacin
Quinolone Naldixic acid
Folic Acid
Synthesis
Sulfonamide
Sulfamethoxazole
(SMX)
Ag
Sulfadiazine
Sulfasalazine Sulfisoxazole
DHFR Inhibitors Trimethoprim(tmp) Pirymethamine
DNA (damage) Metronidazole
mRNA Synthesis Rifampicin