The document provides an overview of the autonomic nervous system (ANS). It discusses that the ANS is not under conscious control and regulates functions like blood pressure, heart rate, and gland secretion. It describes the two divisions of the ANS as the sympathetic and parasympathetic nervous systems. Key differences between the two divisions are described such as neurotransmitters, locations of ganglia, and effects on target organs. Examples of neurotransmitters, receptor types, and locations are outlined. Common drugs that target the adrenergic and cholinergic systems are also summarized along with their indications and actions.
2. Today's Session
TOPICS ON DISCUSSION
INTRODUCTION
SUB DIVISIONS
DIFFERENCE FROM SOMATIC NERVOUS SYSTEM
ORIGIN
NEUROTRANSMITTER
RESPONSE/ACTION
FUNCTIONS
3. What is
ANS?
AUTO= SELF, NOMIC= GOVERNING
• not under conscious control
• peripheral nervous system innervating
smooth muscle, cardiac muscle, glands
• although subject to reflex and cerebral
control
• Regulates blood pressure, heart rate,
intestinal motility, diameter's of pupils, etc
• Has 2 neurons: preganglionic neuron and
post ganglionic neuron
7. PARA SYMPATHETIC
• Long preganglionic
• Short post ganglionic axon
• Pre ganglionic by C3, C7, C9 and C10, Sacral
nerves
• preganglionic axon pass to parasympathetic
ganglia near to target organ, by synapse with
short postganglionic nerve
• Extensive intrinsic gastrointestinal NS
• Innervation to organs in the thoracic and
lumbar parts via vagus nerve
SYMPATHETIC
• Short pre ganglionic axon
• long post ganglionic axon
• Preganglionic: leave spinal cord of ventral
root of T1 through L3/L4
• Thus called thoracolumbar system
• Ventral root
•
• Ramus
• Sympathetic trunk ( paravertebral
sympathetic ganglion chain)
Post ganglionic axons
8. PARA SYMPATHETIC
• Cholinergic
• Discrete effects on particular effects
• Digestion
• absorption
• Increasing gastric secretion
• increased intestinal motility
• anabolic/ restorative NS
• Rest and digest NS
• Decreases HR
• Pupillary constriction
• Iris constrict
• Bronchoconstriction
• Sphincter relax
• Muscle wall relax
SYMPATHETIC
• Adrenergic
• Fight or flight
• Increase in HR
• Increase in BP
• Dilatation of pupil
• Blood glucose level high
• high free fatty acid
• increased state of arousal
• Emergency
• prolonged circulation of epinephrine and
norepinephrine
• Iris dilate
• Bronchodilation
• Sphincter constrict
ACTION
9.
10. Sympathetic Parasympathetic
Origin T1 to L2 or L3 C3,7,9,10,S2,S3,S4
Distribution Wide Head neck trunk
Ganglia Far Close/on to organ
Post ganglionic Long Short
Pre: Post ganglionic
fibre ratio
1:20 or 1:100 1:1 or 1:2
Transmitter NA, Ach (piloerector,
sweat gland)
Ach
Stability of
transmitter
stable Destroyed rapidly
locally