This document discusses common diseases of the anal region, including haemorrhoids, fissures, perianal abscesses, and fistulas. It describes the symptoms, causes, diagnosis, and various surgical treatment options for each condition. For fistulas, it covers physical examination techniques, imaging modalities like MRI and endoanal ultrasound, and different procedures like seton placement, fistulotomy, fibrin glue, the LIFT procedure, VAAFT, and fistula laser closure. The goals of fistula surgery are to eradicate the disease while preserving continence and preventing recurrence.
Fistula in ano new operation Sloft (Submucosal Ligation Of Fistula Tract)dilip pathak
New minimally invasive operation for fistula in ano -
SLOFT (Submucosal Ligation Of Fistula Tract)
Has very less morbidity and early recovery with no technology needed, hence economical.
the slides contain the aetiology, types, theories related with the aetiology of fistula in ano, basic images, goodsalls rule...
first slide is having the image of the anus pluged with the proctoscope(slit) with metallic probe pased through the internal opening to the external opening.
Fistula in ano new operation Sloft (Submucosal Ligation Of Fistula Tract)dilip pathak
New minimally invasive operation for fistula in ano -
SLOFT (Submucosal Ligation Of Fistula Tract)
Has very less morbidity and early recovery with no technology needed, hence economical.
the slides contain the aetiology, types, theories related with the aetiology of fistula in ano, basic images, goodsalls rule...
first slide is having the image of the anus pluged with the proctoscope(slit) with metallic probe pased through the internal opening to the external opening.
Fistula in ano is a difficult disease to cure by medicines or surgery. Kshar sutra treatment is proven definite treatment for permanent cure of Fistula in ano
Fistula in ano sloft technic by dr d.u.pathakdilip pathak
This is new minimally invasive method to treat fistula in ano. It is more simple hence reproducible than LIFT. SLOFT is Submucosal Ligation Of Fistula Tract. Developed by Dr D.U.Pathak from Jabalpur MP ( 094251-52747) email dupathak@gmail.com for further details
a basic and concise description of one of the most common clinical condition we encounter in our daily practice. this info has been gathered from several sources. feel free to point out any mistakes. :)
hydrosalphinx in accumulation fluid in fallopian tube that make problems for sperm to pass through the tube to meet te oocyte. People who want to get pregnant should meet the doctor to solve this problem. pregnancy can achieve after operation by laparoscopic for diagnostic and treatment
Fistula in ano is a difficult disease to cure by medicines or surgery. Kshar sutra treatment is proven definite treatment for permanent cure of Fistula in ano
Fistula in ano sloft technic by dr d.u.pathakdilip pathak
This is new minimally invasive method to treat fistula in ano. It is more simple hence reproducible than LIFT. SLOFT is Submucosal Ligation Of Fistula Tract. Developed by Dr D.U.Pathak from Jabalpur MP ( 094251-52747) email dupathak@gmail.com for further details
a basic and concise description of one of the most common clinical condition we encounter in our daily practice. this info has been gathered from several sources. feel free to point out any mistakes. :)
hydrosalphinx in accumulation fluid in fallopian tube that make problems for sperm to pass through the tube to meet te oocyte. People who want to get pregnant should meet the doctor to solve this problem. pregnancy can achieve after operation by laparoscopic for diagnostic and treatment
Tooth extraction is a common practice for the oral surgeons. As a post extraction complication, formation of a communication between oral cavity & maxillary sinus through the socket of alveolar bone during extraction of maxillary premolars & molars, which is known as oroantral fistula is also a common phenomenon. If it can’t be early diagnosed & treated, chronic sinusitis of maxillary sinus may occur which is a very painful condition of cranium.
Long segment urethral strictures with a very narrow lumen pose an immense challenges for buccal mucosa augmentation urethroplasty.
Larger discrepancy in size of the graft and the native urethral plate makes it difficult to place the sutures and also makes the graft vulnerable to contracture and fibrosis.
Increasing the width of the urethral plate by a vertical midline mucosal incision and applying an additional inlay buccal mucosal graft may lessen the discrepancy and help in improving the adequacy of the urethral lumen.
Other option to deal with these kind of strictures is dorsal onlay and ventral inlay.
Spongiofibrosis is never full thickness except in traumatic injury ( straddle injury/blunt trauma)
Partial thickness Spongiofibrosis and scarred mucosa can be removed completely and replaced by buccal mucosa.
Lithotomy position
Epidural + general anesthesia.
Vertical perineal incision. Mobilization of bulbar urethra
Dorsal ( one side kulkarni’s technique)or ventral urethrotomy
Vertical midline incision or complete removal of scarred urethral plate with removal of thin layer of spongiofibrosis.
Inlay and onlay grafting done
Urethra closed over 16 fr
Results were analysed on the basis of pre and post operative uroflowmetry.
Any kind of instrumentation was considered as failure.
Mean follow up 630 days.
22 patients have significant better flow rate after surgery
One patient developed ring stricture near proximal anastomosis and managed by urethral dilatation.
One patient developed abscess followed by urine leak and was managed conservatively with indwelling catheter and antibiotics.
Combined urethroplasty avoid complete transection of urethra.
It widens the native urethral plate in an anatomical manner
Reduces the disparity between urethral plate and onlay buccal mucosa.
improves the success rate of long and very narrow bulbar urethra strictures
Long segment urethral strictures with a very narrow lumen pose an immense challenges for buccal mucosa augmentation urethroplasty.
Larger discrepancy in size of the graft and the native urethral plate makes it difficult to place the sutures and also makes the graft vulnerable to contracture and fibrosis.
Increasing the width of the urethral plate by a vertical midline mucosal incision and applying an additional inlay buccal mucosal graft may lessen the discrepancy and help in improving the adequacy of the urethral lumen.
Other option to deal with these kind of strictures is dorsal onlay and ventral inlay.
Spongiofibrosis is never full thickness except in traumatic injury ( straddle injury/blunt trauma)
Partial thickness Spongiofibrosis and scarred mucosa can be removed completely and replaced by buccal mucosa.
Lithotomy position
Epidural + general anesthesia.
Vertical perineal incision. Mobilization of bulbar urethra
Dorsal ( one side kulkarni’s technique)or ventral urethrotomy
Vertical midline incision or complete removal of scarred urethral plate with removal of thin layer of spongiofibrosis.
Inlay and onlay grafting done
Urethra closed over 16 fr
Results were analysed on the basis of pre and post operative uroflowmetry.
Any kind of instrumentation was considered as failure.
Mean follow up 630 days.
22 patients have significant better flow rate after surgery
One patient developed ring stricture near proximal anastomosis and managed by urethral dilatation.
One patient developed abscess followed by urine leak and was managed conservatively with indwelling catheter and antibiotics.
Combined urethroplasty avoid complete transection of urethra.
It widens the native urethral plate in an anatomical manner
Reduces the disparity between urethral plate and onlay buccal mucosa.
improves the success rate of long and very narrow bulbar urethra strictures
Similar to ANO RECTAL DISEASES- MANAGEMENT OPTIONS (20)
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
4. Constipation and prolonged
straining when using the
toilet are thought to
contribute to the formation
of haemorrhoids by
increasing the pressure in the
veins
29. PERIANAL FISTULA
Chronic abnormal communication, lined by granulation
tissue, with internal opening in the anal canal and
external opening on the skin of the perineum or buttock
29
42. MRI
• 96% sensitivity and
90% specificity –
internal opening
• Inv of choice for
• complex fistula
• Recurrent fistula
42
43. Endoanal
Ultrasonography
• 360 degree rotating probe
• 7- or 10-MHz transducer with a hard plastic
water-filled sonolucent cone over the
transducer
• Fistula tracts and abscesses - hypoechoic
defects
• Muscular anatomy in relation to abscess and
fistula
• Hydrogen peroxide acts as contrast
• Limitation – cost, availability, expertise
43
46. Anorectal
Manometry
Help identify patient at risk
of post op incontinence
Indications
• Suspected sphincter impairment
• H/O difficult labor
• H/O previous fistulotomy
• High fistulas
• Elderly
49. Seton
Materials
• Silk , Nylon, Prolene, Vessel
loops, Rubber bands
Draining seton
Cutting seton
50
Success rate – 80%, one third – disturbance of incontinence
50. Fistulotomy
• Identify the tract
• Assess extent of sphincter
involvement
• Division of all structures lying
between external and internal
opening
• Tract laid open and the tract
curettage done
• Surest way of getting rid of fistula
• Success rate – 93 to 100% ,
Incontinence – 11.5 to 20%
51
61. LIFT
62
Ligation of intersphincteric fistula tract (LIFT)
2007 – Rojanasakul et al
Based on closure of internal opening,
removal of infected tissue
Disconnection of internal opening from
fistula tract at level of intersphincteric plane
Injection of hydrogen peroxide – help
confirm completeness of procedure
64. VAAFT
65
Video- Assisted Anal Fistula Treatment
Dr P Meinero in 2006
5 mm fistuloscope, irrigation, diathermy
Diagnostic phase – tract and opening evaluated with fistuloscope
Operative phase - cauterize
65. VAAFT
Steps
• Identify tract under vision
• Cauterise & debride fistula wall with bipolar energy
• Endobrush to extract necrotic material
• Internal opening sutured by semicircular/linear stapler or
mucosal flap
• 0.5 ml cyanoacrylate glue to reinforce suture line
Healing rate – 73.5% at 3 months and 87.1% at 12
months
68. Fistula
Laser
Closure
69
FiLaC
Radial emitting laser probe
Destroys the fistula epithelium and obliterates
the tract by shrinkage effect
Includes closure of internal opening with
anorectal flap
Steps – identify – debride – 14 fr catheter-400
micron laser fibre with tip at internal orifice
Recent evidence – paucity of bacteria… chronic infection may not be pathological process
Flap – 5-10mm below internal opening and 10-15mm on either side
Infiltrate with lignocaine or saline with adrenaline
Dissection of primary tract from external opening to external sphinter not necessary but should be drained
Porcine-derived isocyanate crosslinked acellular dermal sheet
Predominantly composed of type I collagen (93–95 %) with additional type III collagen and a small amount of elastin
Fecal incontinence increases with complexity of fistula
More sphincter muscle included in fistulotomy
Females – more prone
Low when external anal sphinter not divided
One study – fistulotomy for intersphinteric fistula (37%) and transsphinteric fistula (54%)
Cutting seton doesn’t eliminate risk of incontinence
2/3rd – incontinence to flatus or liquid stool, 1/3rd to solid stool after use of cutting seton
Loose seton preferred when risk of incontinence is high