ppt

1. DRUGS USE TO TREAT ANEMIA
Prepared by:Dr Touseef (BUMDC)

2. Hematopoiesis

5. Usual Criteria
of Hb in
ANEMIA
>11.5G/dl
in women
>14G/dl in
men

7. Signs and Symptoms:
Patients with a Hb less than 7G/dl will have appear following symptoms ;
Tissue hypoxia
Fatigue
 Headache
 Dyspnea
 Pallor
Angina
 Tachycardia
 Visual impairment
 Syncope
 Lymphadenopathy
 Hepatic and or splenic enlargement
 Bone tenderness
 Blood loss in feces
 Neurologic symptoms.

8. Classification of anemia:
1. Anemia associated with decrease RBC production
 Iron deficiency anemia,
 Megaloblastic anemia
 Thalassemia
 Anemia due to chronic disease and renal failure.
2. Anemia due to increased RBC destruction:
 Haemolytic anemia
 sickle cell anemia

9. Iron:

10. IRON REQUIREMENT

11. CAUSES OF IRON DEFECIENCY ANEMIA

12. Treatment of iron deficiency Anemia

18. Indication for the use of iron

19. Iron Toxicity
Deferasirox
–an oral iron chelator approved for treatment of iron
overload

20. 2- Coblamine vit B12

21. Pharmacokinetics:
• Source: Meat (liver), eggs, & dairy products.
• coblamine is absorbed from the GIT in the presence of intrinsic
factor, a product of the parietal cells of the stomach.
• Plasma transport is accomplished by binding to transcobalamin II.
• Coblamine is stored in the liver in large amounts; a normal
individual has enough to last 5 years.
It is available in 2 forms
1. cyanocobalamine
2. hydroxy cobalamine has a longer circulating half life.

23. •Deficiency leads to anemia, gastrointestinal symptoms,
andneurologic abnormalities.
•Deoxyadenosyl cobalamin
•methylcobalamin
•Cyanocobalamin
•hydroxocobalamin
•Source of vitamin BI2
• meat (especially liver), eggs, and dairyproducts.
•Vitamin B12 is sometimes called extrinsic factor
active forms of the vitamin in
humans
found in food sources are converted
to the active forms

24. PHHARMACOKINETIC

25. 25
Uses:
1- Pernicious Anemia :
(defective secretion of intrinsic factor by the
gastric mucosal cells)
2- Neurologic abnormalities:
3- Gastrectomy
4- Cyanide poisoning.

26. 26

27. Why folic acid give with vitB12

28. Folic acid

34. Erythropoietin