The larynx extends from the laryngeal inlet to the inferior border of the cricoid cartilage. There are 9 cartilages that make up the framework of the larynx, connected by joints, ligaments, and membranes. The larynx contains 8 muscles that move the cartilages and open/close the laryngeal inlet and vocal cords. The larynx develops from the endoderm, branchial arches, and surrounding mesenchyme during embryological development. The infant larynx differs from the adult larynx in its higher position, softer cartilages, and funnel shape.
Surgical anatomy of thyroid and para thyroid glands. hazem el-folldocxmohamedhazemelfoll
Detailed Embrylogy and Anatomy of Thyroid and Parathyroid Glands with the relevant surgical aspects related during Thyroidectomy especially the important Nerve relations.
It is just a concise presentation about anatomy of larynx & TB tree. little bit about anaesthetic consideration regarding vocalcordpalsy and aspiration pneumonitis.
Surgical anatomy of thyroid and para thyroid glands. hazem el-folldocxmohamedhazemelfoll
Detailed Embrylogy and Anatomy of Thyroid and Parathyroid Glands with the relevant surgical aspects related during Thyroidectomy especially the important Nerve relations.
It is just a concise presentation about anatomy of larynx & TB tree. little bit about anaesthetic consideration regarding vocalcordpalsy and aspiration pneumonitis.
Anatomy and physiology of larynx presentation for MBBS 3rd year. This ppt presents the most detailed presentation of anatomy and physiology of larynx. Presenter was third year MBBS students of Nepalgunj Medical College and teaching hospital, Nepalgunj Nepal. Niraj Prasad Sah won the best presentation award for this during ENT posting. Have fun and check this out.
ANATOMY OF LARYNX, VOCAL CORD PALSIES ,.pptxzaaprotta
Anatomy of the Larynx
Cartilaginous Framework and Ligaments:
The larynx consists of several cartilages, both unpaired and paired:
Unpaired Cartilages:
Thyroid Cartilage: The largest laryngeal cartilage, it forms the anterior and lateral portions of the larynx. The prominent anterior projection is commonly known as the “Adam’s apple.”
Cricoid Cartilage: Located below the thyroid cartilage, it forms a complete ring.
Epiglottis: A leaf-shaped cartilage that covers the larynx during swallowing to prevent food aspiration.
Paired Cartilages:
Arytenoid Cartilages: These play a crucial role in vocal fold movement.
Corniculate Cartilages: Sit atop the arytenoids.
Cuneiform Cartilages: Found within the aryepiglottic folds.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Thelarynx extends from the laryngeal inletto
the inferior border of the cricoid cartilage.
3. • Larynx lies opposite the third tosixth cervical
vertebrae, being alittle higher
in women thanin
men.
•Theinfantile larynx
is proportionally
smaller and is more
funnel shaped.
4. Measurements
• Until puberty there is little difference b/w male &
female larynx.
• After puberty:- Male larynxundergoes
considerable increase
In Males In Females
Length 44 mm 36 mm
Transversediameter 43 mm 41mm
A-Pdiameter 36 mm 26 mm
Circumference 136 mm 112 mm
5. Theframework of the larynx
• Hyoid bone
• 9 Cartilages: –
Connected by
• Joints
• Ligaments
• Membranes
• Moved by
• 8 Muscles(Intrinsic)
• Cavity – Mucous membrane
8. ThyroidCartilage
• Shield shaped, open posteriorly, angulated
anteriorly
• Largest cartilage of larynx
• Protect larynx
• Provide an attachment to vocalcords
9.
10.
11.
12.
13. • Thelateral thyrohyoid ligament connectsthe
tip of the superior cornua of the thyroid
cartilage to the posterior ends of the greater
cornua of thehyoid.
• Theligaments often contain asmall nodule of
cartilage, the cartilagotriticea
14.
15. Onthe external surface of eachlamina, anoblique
line
curves downwards and forwards from thesuperior
thyroid tubercle, situated just in front of the root of
the superior horn, to the inferior thyroid tubercle
on the lower border of the lamina.
Thisline marks the attachment ofthe
Thyrohyoid,
Sternothyroid
Inferior constrictor muscles.
16.
17.
18. • Avertical ridge in the midline of thelamina
givesattachment to
longitudinal muscleof the oesophagus
and produces ashallow concavity on each
side for the origin ofthe
posterior cricoarytenoidmuscle.
• Theentire inner surface of the cricoid
cartilage is lined with mucousmembrane.
23. Pre-epiglottic spaceof Boyer
Anterior surface of infrahyoid epiglottis is
separated from thyrohyoid membrane and
thyroid cartilage by fat filled pre-epiglottic
space.
Pre-epiglottic space invaded by carcinoma of
supraglottic larynx and the base of tongue.
24.
25. Boundaries
Anterior: Upper part of thyroid cartilageand
thyrohyoid membrane.
Superior: Hyoepiglottic ligament.
Posterior: Infrahyoid epiglottis.
Inferior: Thyroepiglottic ligament.
Communication: Laterally itis continuous with
paraglottic space.
26.
27.
28.
29. • Thyroid
• Cricoid
• Arytenoids
(Exceptits tip)
Hyaline Cartilage
May ossify after 20
yrs (Male)(T→C→A)
complete by 65yrs.
Fibroelastic
Theydo not ossify
• Epiglottis
• Corniculate
• Cuneiform
• Tip ofArytenoid
33. Thyrohyoidmembrane
median thyrohyoid ligament 2lateral thyrohyoid ligament
superior cornua of the
thyroid cartilage to the
posterior ends of the
greater cornua of the
hyoid. Small nodule of
cartilage, CARTILAGO
TRITICEA
35. Intrinsic
•Part of Fibro-elasticMembrane
which lies beneaththe
mucous membrane of the
larynx.
•Thefibro-elastic membrane
is divided into anupper
and lower part bythe
laryngeal ventricle.
46. Ventricle (Sinus of larynx) /sinus of
Morgagni:
• This deep elliptical spacelies
between
vestibular
and vocal folds.
47. • Thesubmucosaof the ventricle
contains numerous seromucinous
glands.
• Thesecretions produced by these
exocrine glands provide both
mechanical and immune (lysozyme)
protection for the vocalfolds.
48. Laryngeal saccule/ Sacculeof Hilton
• At the anterior endof
the ventricle is a
diverticulum
• Thesaccule (of Hilton) is
lined with mucous
glands, which are
thought to lubricate the
vocal folds
49. • Abnormal dilatation of the saccule results
in an air-filled laryngocele that should be
distinguished
from amucoceleof the saccule(saccular
cyst),which lacks free communication with the
ventricle not airfilled
52. • most of the laryngeal foreignbodies are seen
in supraglotticregionlying above the vocal
cords.
• Subglotticregion(Infraglottic larynx):
• Extendsfrom below the vocal cords tolower
border of cricoidcartilage.
53. Glottis (Rimaglottidis):
• This narrowest part of an adultlaryngeal
cavity liesbetween
vocal cords and
arytenoids of the
two sides.
57. Pre-epiglottic space ofBoyer
• Pre-epiglottic space can be invaded by
carcinoma of supraglottic larynx and the base
of tongue.
58. Paraglottic space lTuckersSpace:
It communicates withpre-epiglottic
space (Anteriorsuperioly)
•Boundaries:
Laterally:
Thyroid cartilage and
cricothyroid membrane.
Medial:
Conus elasticus,
Ventricle and quadrangular
membrane.
Posterior:
Anterior mucosa ofpyriform
fossa.
59. Paraglottic space lTuckersSpace:
• Growths invading paraglottic spacedestroy
cricothyroid Membrane
• Ventricle tumors -> spread transglottically
• Vocal cord tumors involving thyroarytenoid
muscle -> subglottic and extralaryngeal region.
• Lateral supraglottic tumors cantravel to
subglottic region ->the inner surface of
thyroid.
• Pyriformfossa tumor ->into endolarynx andfix
vocal folds
60. Reinke’sspace
• This potential space has scantysubepithelial
connective tissues and lies under the
epithelium of vocalcords.
• It is boundedby–
Above and below:Arcuatelines.
Anterior: Anterior commissure.
Posterior: Vocal process ofarytenoids.
61. Layered structure of the vocalfold
• Lamina Propria- 3Layers
1. Superficial-fibrous Substance(Reinkesspace)
2. Intermediate –elastic
3. Deep– Collagen fibres
VOCALLIGAMENT formed
By Intermediate and deep
layer
Body contain Vocalismuscle
62. MUSCLESOFLARYNX
• There are two types of laryngealmuscles
intrinsic (connecting laryngeal cartilages
to eachother)
extrinsic(connecting larynx to the
surrounding structures).
63. Intrinsic muscles
They are further divided intotwo:
1) muscles acting on vocalcords
2) muscles acting on laryngealinlet.
Vocal cords
Abductors: Posterior cricoarytenoid
Adductors: Lateralcricoarytenoid
Interarytenoid (transverse andoblique
arytenoids)
Thyroarytenoid (external part)
Tensors:
Relaxers:
Cricothyroid
Vocalis & Thyroarytenoid internalpart
77. EMBRYOLOGICALDEVELOPMENT
Structure Source
laryngeal mucosa Endoderm of cephalic part
of foregut
laryngeal cartilages mesenchyme
Epiglottis Hypobranchial eminence
Upper part of body ofhyoid bone
Lessercornua of hyoid bone
Stylohyoid ligament
2nd branchial arch
Lower part of body of hyoidbone
and greater cornua
3rd branchial arch
78. 4th branchialUpper part of thyroidcartilage
arch
arch
lower part of thyroidcartilage,
th
cricoid, corniculate, and cuneiform 6
cartilages
Intrinsic muscles of larynx 6th branchialArch
79. Infant LarynxVSAdultLarynx
Infant Larynx Adult Larynx
higher in the neck
Vocalcords lie at C3/C4level
During swallowing go up to C1/C2level.
Low
Vocal cords lie at C5level.
Laryngeal cartilages are soft and
collapse easily.
Cartilage undergo ossification
Epiglottis: omegashaped& Floppy Firmand flatter
Arytenoids: large
Thyroid:flat.
Cricoid: Thediameter of cricoidissmaller
than glottis
subglottisis the narrowest portion
Glottisis the narrowest portion
Cricothyroid and thyrohyoid spaces:They
are very narrow
80. Infant Larynx Adult Larynx
Size:smaller and hasanarrower lumen. Wider lumen
Shape:It is conicalandfunnel-shaped columnshaped
Submucosal tissue: It is thick andloose
and becomes easily
edematous in response to traumaor
inflammation