This document discusses anesthesia considerations for robotic surgery. It covers the physiological impacts of steep Trendelenburg positioning and pneumoperitoneum, including increased filling pressures, pulmonary effects, abdominal effects, and neurological impacts. It also reviews common complications and the anesthetic management of positioning, monitoring, ventilation, and perfusion management during robotic surgery.
Anesthesia in ophthalmic surgery and complicationsDR SHADAB KAMAL
Anesthesia for ophthalmic surgery presents unique challenges for the anesthesiologist, including regulation of intraocular pressure and prevention of complications. The document discusses ocular anatomy and physiology, techniques of anesthesia like facial nerve blocks and general anesthesia, considerations for preoperative evaluation, and complications. Precise control of drugs and positioning are important due to the sensitivity of the eye and potential effects on vision.
Anesthesia in ophthalmic surgery dr ferdous Ferdous101531
This document discusses anesthesia considerations for ophthalmic surgery. It covers various techniques including general anesthesia, local anesthesia, and different regional block techniques. It discusses preoperative evaluation and management of comorbidities. Complications related to different techniques are outlined such as increases in intraocular pressure, retrobulbar hemorrhage, oculocardiac reflex, brainstem anesthesia, and postoperative nausea and vomiting. Agents, adjuvants, and proper techniques are emphasized to minimize risks and complications during ophthalmic anesthesia.
The document discusses anaesthetic management for neurosurgery. It outlines how cerebral blood flow is regulated and the importance of maintaining cerebral perfusion pressure and intracranial pressure. The goals of anaesthesia are to provide optimal surgical conditions while maintaining stable haemodynamics and brain oxygenation levels. Common procedures are described along with considerations for preoperative assessment, induction, maintenance of anaesthesia and fluid management during craniotomy to minimize risks to the patient.
This document discusses the scalp block technique. It begins by describing scalp block as local anesthesia of the scalp nerves. It then discusses the history and development of scalp block, including the original description in 1986 and studies in the 1980s that demonstrated its effectiveness in reducing hemodynamic changes during craniotomy. The document outlines the specific nerves blocked in scalp block and techniques for each, and notes bupivacaine is often used. Advantages include decreased blood pressure and intracranial pressure changes during surgery. Potential complications are also reviewed. Finally, it briefly discusses recent updates to the Glasgow Coma Scale including the addition of a pupil reactivity score in 2018.
1. The document reviews anatomy of the orbit and surrounding structures relevant to ophthalmic anesthesia. It describes nerves, muscles, vasculature and layers within the orbit.
2. Various local anesthetic agents and their properties are discussed. Common techniques for ophthalmic anesthesia including topical, subconjunctival, intracameral, peribulbar, retrobulbar, and facial nerve blocks are explained.
3. Risks associated with different techniques like retrobulbar hemorrhage, globe perforation, and brainstem anesthesia are outlined. The document provides an overview of orbital anatomy and ophthalmic anesthesia techniques and considerations.
Anesthesia management for pituitary tumorAbhijit Nair
This document discusses anesthesia management for pituitary tumor surgery. Pituitary adenomas are common benign tumors that can invade surrounding structures. Risk factors include genetic conditions. Pre-operative evaluation assesses hormonal levels and effects, as well as comorbidities related to hormonal hypersecretion like acromegaly and Cushing's syndrome. Anesthetic management aims to maintain hemodynamic stability, cerebral oxygenation, and facilitate surgery while preventing complications. Special considerations include potential airway difficulties and post-operative hormone replacement or complications such as diabetes insipidus or hyponatremia.
Anaesthesia for elective neurosurgery journal (zuhura)AnaestHSNZ
This document summarizes key aspects of anaesthesia for elective neurosurgery. It discusses the importance of maintaining optimal cerebral perfusion pressure and oxygenation. While volatile agents remain popular, studies have found propofol and sevoflurane to be suitable options. Propofol may help reduce intracranial pressure and cerebral blood volume compared to other agents. Awake craniotomy techniques are gaining popularity for removal of brain lesions near eloquent areas to allow for neurological monitoring during the procedure. Advances in minimally invasive techniques continue to offer benefits like reduced trauma and faster recovery times.
Anesthesia for ophthalmic surgery 18-12-2016Aftab Hussain
This document discusses the concerns and considerations for anesthesia during ophthalmic surgery. The key concerns include maintaining adequate akinesia, analgesia, and control of intraocular pressure while preventing complications such as the oculocardiac reflex, intraocular gas expansion, and postoperative nausea and vomiting. Careful patient evaluation, choice of anesthesia technique, monitoring of vital signs and intraocular pressure, and use of medications are important to have smooth induction, maintenance and emergence from anesthesia.
Anesthesia in ophthalmic surgery and complicationsDR SHADAB KAMAL
Anesthesia for ophthalmic surgery presents unique challenges for the anesthesiologist, including regulation of intraocular pressure and prevention of complications. The document discusses ocular anatomy and physiology, techniques of anesthesia like facial nerve blocks and general anesthesia, considerations for preoperative evaluation, and complications. Precise control of drugs and positioning are important due to the sensitivity of the eye and potential effects on vision.
Anesthesia in ophthalmic surgery dr ferdous Ferdous101531
This document discusses anesthesia considerations for ophthalmic surgery. It covers various techniques including general anesthesia, local anesthesia, and different regional block techniques. It discusses preoperative evaluation and management of comorbidities. Complications related to different techniques are outlined such as increases in intraocular pressure, retrobulbar hemorrhage, oculocardiac reflex, brainstem anesthesia, and postoperative nausea and vomiting. Agents, adjuvants, and proper techniques are emphasized to minimize risks and complications during ophthalmic anesthesia.
The document discusses anaesthetic management for neurosurgery. It outlines how cerebral blood flow is regulated and the importance of maintaining cerebral perfusion pressure and intracranial pressure. The goals of anaesthesia are to provide optimal surgical conditions while maintaining stable haemodynamics and brain oxygenation levels. Common procedures are described along with considerations for preoperative assessment, induction, maintenance of anaesthesia and fluid management during craniotomy to minimize risks to the patient.
This document discusses the scalp block technique. It begins by describing scalp block as local anesthesia of the scalp nerves. It then discusses the history and development of scalp block, including the original description in 1986 and studies in the 1980s that demonstrated its effectiveness in reducing hemodynamic changes during craniotomy. The document outlines the specific nerves blocked in scalp block and techniques for each, and notes bupivacaine is often used. Advantages include decreased blood pressure and intracranial pressure changes during surgery. Potential complications are also reviewed. Finally, it briefly discusses recent updates to the Glasgow Coma Scale including the addition of a pupil reactivity score in 2018.
1. The document reviews anatomy of the orbit and surrounding structures relevant to ophthalmic anesthesia. It describes nerves, muscles, vasculature and layers within the orbit.
2. Various local anesthetic agents and their properties are discussed. Common techniques for ophthalmic anesthesia including topical, subconjunctival, intracameral, peribulbar, retrobulbar, and facial nerve blocks are explained.
3. Risks associated with different techniques like retrobulbar hemorrhage, globe perforation, and brainstem anesthesia are outlined. The document provides an overview of orbital anatomy and ophthalmic anesthesia techniques and considerations.
Anesthesia management for pituitary tumorAbhijit Nair
This document discusses anesthesia management for pituitary tumor surgery. Pituitary adenomas are common benign tumors that can invade surrounding structures. Risk factors include genetic conditions. Pre-operative evaluation assesses hormonal levels and effects, as well as comorbidities related to hormonal hypersecretion like acromegaly and Cushing's syndrome. Anesthetic management aims to maintain hemodynamic stability, cerebral oxygenation, and facilitate surgery while preventing complications. Special considerations include potential airway difficulties and post-operative hormone replacement or complications such as diabetes insipidus or hyponatremia.
Anaesthesia for elective neurosurgery journal (zuhura)AnaestHSNZ
This document summarizes key aspects of anaesthesia for elective neurosurgery. It discusses the importance of maintaining optimal cerebral perfusion pressure and oxygenation. While volatile agents remain popular, studies have found propofol and sevoflurane to be suitable options. Propofol may help reduce intracranial pressure and cerebral blood volume compared to other agents. Awake craniotomy techniques are gaining popularity for removal of brain lesions near eloquent areas to allow for neurological monitoring during the procedure. Advances in minimally invasive techniques continue to offer benefits like reduced trauma and faster recovery times.
Anesthesia for ophthalmic surgery 18-12-2016Aftab Hussain
This document discusses the concerns and considerations for anesthesia during ophthalmic surgery. The key concerns include maintaining adequate akinesia, analgesia, and control of intraocular pressure while preventing complications such as the oculocardiac reflex, intraocular gas expansion, and postoperative nausea and vomiting. Careful patient evaluation, choice of anesthesia technique, monitoring of vital signs and intraocular pressure, and use of medications are important to have smooth induction, maintenance and emergence from anesthesia.
The document provides guidelines from the American Society of Regional Anesthesia (ASRA) on placing and removing epidural catheters in patients taking anticoagulant and antiplatelet drugs. It lists recommended minimum times to wait after the last dose of various medications before catheter placement and removal, as well as when to restart anticoagulation therapy after removal. The medications are grouped into heparins, low molecular weight heparins, factor Xa and direct thrombin inhibitors, antiplatelet agents, fibrinolytics, and glycoprotein IIb/IIIa inhibitors. For each group, it provides the drug names and recommended waiting times.
This document discusses anaesthesia considerations for ophthalmology surgery. It begins with the anatomy of the eye and nerve supply. It then discusses various types of eye surgeries and choices of anaesthesia, including regional blocks and general anaesthesia. Key issues are managing intraocular pressure, the oculocardiac reflex, drug effects, and risks with nitrous oxide and anticoagulants. Factors that increase or decrease intraocular pressure during surgery are outlined. The document provides guidance on reducing pressure and handling reflexes to ensure safe ophthalmic anaesthesia.
This document discusses the application of physics principles in anaesthesia. It covers concepts like gas laws, partial pressures, solubility, diffusion, and measurements using different forms of energy. Accurate measurements and understanding relationships like between pressure, volume and temperature are important for safe anaesthesia. Physics principles govern gas flow and exchange in the lungs and tissues, as well as delivery of anaesthetic agents.
Point of critical care Ultrasound play a pivotal role in management of critically ill patients admitted in ICU . Its usage in this regard is ever growing . Here we discus about pearls and pitfalls of POCUS in Intensive care medicine.
This document discusses anaesthesia for eye surgery. It begins with a brief history of local anaesthesia for eye surgery and the development of regional techniques. It then covers anatomy of the eye, orbit and surrounding structures. Factors that influence intraocular pressure are explained, including effects of anaesthetic drugs and muscle relaxants. The document discusses pre-operative evaluation and anaesthetic management considerations for eye surgery, including different anaesthetic techniques and their indications. Post-operative complications are also mentioned.
This document discusses various methods for monitoring the depth of anesthesia. It describes clinical techniques such as assessing autonomic responses and muscle movement. It also discusses pharmacological principles like minimum alveolar concentration for different anesthetic responses. Methods for monitoring brain electrical activity are outlined, including spontaneous EEG, compressed spectral analysis, bispectral index, and entropy monitors. Brain electrical activity monitors provide quantitative measures of anesthetic effect but can be influenced by other physiological factors. Overall, the document provides an overview of traditional and advanced techniques for assessing depth of anesthesia.
Anaesthetic considerations for Robotic Surgery, What to expect, how to go ahead. An update and incite on the intricacies of Robotic Surgery and Anaesthetic implications.
Guillain Barre’ syndrome(GBS) and Anesthesia considerationTenzin yoezer
Patients with GBS need special care when coming to the surgery. They have a high risk of aspiration, airway compromise, autonomic instability, altered response to NMBs. It is the duty of the anesthesia providers to recognize those problems and minimize the complications.
Preoperative Management Of Coronary Stentshospital
This document discusses recommendations for continuing dual antiplatelet therapy (aspirin and clopidogrel) in the perioperative period for patients who have received coronary stents and will undergo surgery. It recommends continuing this medication for 6 weeks for patients with bare metal stents and 12 months for those with drug-eluting stents. Discontinuing clopidogrel alone while maintaining aspirin may be relatively safe for drug-eluting stent patients in the short term. The risk of stent thrombosis is greatest during and immediately after surgery.
Cardiovascular physiology for anesthesiamarwa Mahrous
This document discusses cardiovascular physiology including the structure and function of the heart, regulation of the cardiovascular system, blood flow through the pulmonary and systemic circulations, factors that influence cardiac output and stroke volume, and regulation of the systemic vasculature. Key points include:
- The cardiovascular system consists of the heart, blood vessels, and mechanisms that regulate blood circulation and pressure.
- Cardiac output is determined by stroke volume and heart rate. Stroke volume depends on preload, afterload, and contractility.
- The pulmonary circulation has low pressure and resistance while the systemic circulation has higher pressure and resistance.
- Autonomic nervous system and chemical factors regulate heart rate and contractility. Venous return and vascular
This document summarizes the oxygen cascade from the atmosphere to tissues. It describes how oxygen partial pressure decreases stepwise from the lungs to mitochondria. Key points include how partial pressures, diffusion, hemoglobin binding, and the oxyhemoglobin dissociation curve influence oxygen delivery. Physiologic and pathologic factors that can shift the curve right or left, improving or impairing oxygen release, are also reviewed.
This document provides an overview of anaesthesia considerations for laparoscopy. It discusses how carbon dioxide is used to insufflate the peritoneal cavity and create pneumoperitoneum during laparoscopy. This causes various physiological changes including increased systemic vascular resistance, decreased cardiac output, respiratory effects like elevated diaphragm and hypercarbia. It outlines management of hemodynamic and respiratory complications during laparoscopy. Complications discussed include subcutaneous emphysema, pneumothorax, gas embolism. The document provides details on anaesthetic concerns for patient positioning, estimated blood loss and managing cardiovascular instability during laparoscopy.
HERE IS A SEMINAR BASED ON ALL THE NEWER MODES OF MECHANICAL VENTILATION .
MY SINCERE APOLOGIES , BECAUSE I HAD TO TAKE INFORMATION FROM OTHERS SLIDES TOO , SINCE THERE IS VERY LESS INFORMATION AVAILABLE ABOUT THIS TOPIC
This document discusses low-flow and minimal-flow anesthesia techniques. It begins by defining low-flow as a fresh gas flow of 1 L/min and minimal-flow as 0.5 L/min. Rebreathing systems allow reuse of exhaled gases after removal of carbon dioxide. Using these techniques can reduce costs by 55-75% and minimize environmental pollution from volatile anesthetic gases. Proper monitoring and maintenance of breathing gas conditions is important for patient safety when using low fresh gas flows.
This document provides an overview of cardiovascular monitoring during anesthesia. It discusses the importance of monitoring heart rate, blood pressure, and other parameters to detect changes early and intervene to reduce risks. Both indirect and direct methods of measuring arterial blood pressure are described in detail, including oscillometry, Doppler, tonometry and intra-arterial cannulation. The principles of transducers, damping, natural frequency, and resonance in pressure monitoring systems are also summarized.
This document discusses pituitary gland disorders and anesthetic management. Key points include:
1. Pituitary tumors can cause hormonal imbalances and compression of surrounding structures, requiring careful perioperative management.
2. Patients may have hypopituitarism requiring steroid supplementation or acromegaly/Cushing's disease resulting in distinctive physical features and comorbidities.
3. Anesthesiologists must consider each patient's specific hormonal status and tumor effects when planning airway management and hemodynamic support for pituitary surgery.
THRIVE is a method using warmed, humidified high flow oxygen via the nose to increase apnea time in patients with difficult airways. It works by flushing carbon dioxide from the nasopharynx, providing mechanical splinting and distention pressure, and allowing apneic oxygenation. A case series of 25 patients with difficult airways found THRIVE increased the median apnea time to 17 minutes without any oxygen saturations dropping below 90%, allowing more time for airway management. While observational and involving expert airway management, the study concludes THRIVE can safely extend the apnea window for difficult airway situations.
This document provides an outline and overview of controlled hypotension during anesthesia. It begins with definitions and a brief history of controlled hypotension. It then discusses the principles and techniques of inducing hypotension, including pharmacological agents like sodium nitroprusside, nitroglycerin, beta blockers, and calcium channel blockers. It also covers non-pharmacological techniques like positioning and acute normovolemic hemodilution. Monitoring, fluid management, and postoperative care are also outlined. The document concludes with sample multiple choice questions related to controlled hypotension.
This document discusses SvO2 and ScvO2 monitoring. SvO2 measures oxygen saturation from blood in the pulmonary artery and requires a pulmonary artery catheter. It provides information about whole body oxygen utilization. A decreased SvO2 indicates increased tissue oxygen extraction, while an increased SvO2 demonstrates decreased extraction and adequate cardiac output to meet tissue needs. ScvO2 can be used as a surrogate for SvO2. Monitoring SvO2/ScvO2 can help guide resuscitation and understand if oxygen delivery meets demand, but risks are associated with pulmonary artery catheters and values must be interpreted in clinical context.
This document discusses anesthesia considerations for bariatric surgery. It begins with definitions of obesity classifications based on BMI. It then discusses the increased risks that obese patients face from cardiovascular and pulmonary complications. Key points in the anesthetic management include careful preoperative evaluation and optimization of comorbidities, strategies for airway management and ventilation given the increased risk of difficulties, appropriate patient positioning and monitoring during surgery, and thromboprophylaxis given the risk of VTE. Overall anesthetic goals are to prevent hypoxemia and carefully manage any cardiovascular or pulmonary issues.
This document discusses the anesthetic considerations and complications related to laparoscopic surgeries. It notes that laparoscopy requires increased intra-abdominal pressure from insufflation of carbon dioxide gas, which can affect cardiovascular and respiratory physiology. The anesthesiologist must monitor for and manage increases in carbon dioxide levels as well as potential complications like gas embolism, pneumothorax, subcutaneous emphysema, and hemodynamic changes due to patient positioning. Proper preoperative evaluation, intraoperative monitoring, and postoperative care can help prevent or address issues arising from laparoscopic procedures.
This document presents the case of a 43-year-old male who underwent CABG surgery due to significant instent stenosis in his LAD artery. He experienced severe hypotension, ST elevation, and conduction defects post-operatively despite maximal medical and invasive management. The document reviews the pathophysiological effects of cardiopulmonary bypass that may have contributed to his condition, including systemic inflammatory response syndrome and vasoplegic syndrome. It also outlines his critical status in the cardiac ICU and the challenges in managing his circulatory failure, arrhythmias, organ dysfunction, and open sternum.
The document provides guidelines from the American Society of Regional Anesthesia (ASRA) on placing and removing epidural catheters in patients taking anticoagulant and antiplatelet drugs. It lists recommended minimum times to wait after the last dose of various medications before catheter placement and removal, as well as when to restart anticoagulation therapy after removal. The medications are grouped into heparins, low molecular weight heparins, factor Xa and direct thrombin inhibitors, antiplatelet agents, fibrinolytics, and glycoprotein IIb/IIIa inhibitors. For each group, it provides the drug names and recommended waiting times.
This document discusses anaesthesia considerations for ophthalmology surgery. It begins with the anatomy of the eye and nerve supply. It then discusses various types of eye surgeries and choices of anaesthesia, including regional blocks and general anaesthesia. Key issues are managing intraocular pressure, the oculocardiac reflex, drug effects, and risks with nitrous oxide and anticoagulants. Factors that increase or decrease intraocular pressure during surgery are outlined. The document provides guidance on reducing pressure and handling reflexes to ensure safe ophthalmic anaesthesia.
This document discusses the application of physics principles in anaesthesia. It covers concepts like gas laws, partial pressures, solubility, diffusion, and measurements using different forms of energy. Accurate measurements and understanding relationships like between pressure, volume and temperature are important for safe anaesthesia. Physics principles govern gas flow and exchange in the lungs and tissues, as well as delivery of anaesthetic agents.
Point of critical care Ultrasound play a pivotal role in management of critically ill patients admitted in ICU . Its usage in this regard is ever growing . Here we discus about pearls and pitfalls of POCUS in Intensive care medicine.
This document discusses anaesthesia for eye surgery. It begins with a brief history of local anaesthesia for eye surgery and the development of regional techniques. It then covers anatomy of the eye, orbit and surrounding structures. Factors that influence intraocular pressure are explained, including effects of anaesthetic drugs and muscle relaxants. The document discusses pre-operative evaluation and anaesthetic management considerations for eye surgery, including different anaesthetic techniques and their indications. Post-operative complications are also mentioned.
This document discusses various methods for monitoring the depth of anesthesia. It describes clinical techniques such as assessing autonomic responses and muscle movement. It also discusses pharmacological principles like minimum alveolar concentration for different anesthetic responses. Methods for monitoring brain electrical activity are outlined, including spontaneous EEG, compressed spectral analysis, bispectral index, and entropy monitors. Brain electrical activity monitors provide quantitative measures of anesthetic effect but can be influenced by other physiological factors. Overall, the document provides an overview of traditional and advanced techniques for assessing depth of anesthesia.
Anaesthetic considerations for Robotic Surgery, What to expect, how to go ahead. An update and incite on the intricacies of Robotic Surgery and Anaesthetic implications.
Guillain Barre’ syndrome(GBS) and Anesthesia considerationTenzin yoezer
Patients with GBS need special care when coming to the surgery. They have a high risk of aspiration, airway compromise, autonomic instability, altered response to NMBs. It is the duty of the anesthesia providers to recognize those problems and minimize the complications.
Preoperative Management Of Coronary Stentshospital
This document discusses recommendations for continuing dual antiplatelet therapy (aspirin and clopidogrel) in the perioperative period for patients who have received coronary stents and will undergo surgery. It recommends continuing this medication for 6 weeks for patients with bare metal stents and 12 months for those with drug-eluting stents. Discontinuing clopidogrel alone while maintaining aspirin may be relatively safe for drug-eluting stent patients in the short term. The risk of stent thrombosis is greatest during and immediately after surgery.
Cardiovascular physiology for anesthesiamarwa Mahrous
This document discusses cardiovascular physiology including the structure and function of the heart, regulation of the cardiovascular system, blood flow through the pulmonary and systemic circulations, factors that influence cardiac output and stroke volume, and regulation of the systemic vasculature. Key points include:
- The cardiovascular system consists of the heart, blood vessels, and mechanisms that regulate blood circulation and pressure.
- Cardiac output is determined by stroke volume and heart rate. Stroke volume depends on preload, afterload, and contractility.
- The pulmonary circulation has low pressure and resistance while the systemic circulation has higher pressure and resistance.
- Autonomic nervous system and chemical factors regulate heart rate and contractility. Venous return and vascular
This document summarizes the oxygen cascade from the atmosphere to tissues. It describes how oxygen partial pressure decreases stepwise from the lungs to mitochondria. Key points include how partial pressures, diffusion, hemoglobin binding, and the oxyhemoglobin dissociation curve influence oxygen delivery. Physiologic and pathologic factors that can shift the curve right or left, improving or impairing oxygen release, are also reviewed.
This document provides an overview of anaesthesia considerations for laparoscopy. It discusses how carbon dioxide is used to insufflate the peritoneal cavity and create pneumoperitoneum during laparoscopy. This causes various physiological changes including increased systemic vascular resistance, decreased cardiac output, respiratory effects like elevated diaphragm and hypercarbia. It outlines management of hemodynamic and respiratory complications during laparoscopy. Complications discussed include subcutaneous emphysema, pneumothorax, gas embolism. The document provides details on anaesthetic concerns for patient positioning, estimated blood loss and managing cardiovascular instability during laparoscopy.
HERE IS A SEMINAR BASED ON ALL THE NEWER MODES OF MECHANICAL VENTILATION .
MY SINCERE APOLOGIES , BECAUSE I HAD TO TAKE INFORMATION FROM OTHERS SLIDES TOO , SINCE THERE IS VERY LESS INFORMATION AVAILABLE ABOUT THIS TOPIC
This document discusses low-flow and minimal-flow anesthesia techniques. It begins by defining low-flow as a fresh gas flow of 1 L/min and minimal-flow as 0.5 L/min. Rebreathing systems allow reuse of exhaled gases after removal of carbon dioxide. Using these techniques can reduce costs by 55-75% and minimize environmental pollution from volatile anesthetic gases. Proper monitoring and maintenance of breathing gas conditions is important for patient safety when using low fresh gas flows.
This document provides an overview of cardiovascular monitoring during anesthesia. It discusses the importance of monitoring heart rate, blood pressure, and other parameters to detect changes early and intervene to reduce risks. Both indirect and direct methods of measuring arterial blood pressure are described in detail, including oscillometry, Doppler, tonometry and intra-arterial cannulation. The principles of transducers, damping, natural frequency, and resonance in pressure monitoring systems are also summarized.
This document discusses pituitary gland disorders and anesthetic management. Key points include:
1. Pituitary tumors can cause hormonal imbalances and compression of surrounding structures, requiring careful perioperative management.
2. Patients may have hypopituitarism requiring steroid supplementation or acromegaly/Cushing's disease resulting in distinctive physical features and comorbidities.
3. Anesthesiologists must consider each patient's specific hormonal status and tumor effects when planning airway management and hemodynamic support for pituitary surgery.
THRIVE is a method using warmed, humidified high flow oxygen via the nose to increase apnea time in patients with difficult airways. It works by flushing carbon dioxide from the nasopharynx, providing mechanical splinting and distention pressure, and allowing apneic oxygenation. A case series of 25 patients with difficult airways found THRIVE increased the median apnea time to 17 minutes without any oxygen saturations dropping below 90%, allowing more time for airway management. While observational and involving expert airway management, the study concludes THRIVE can safely extend the apnea window for difficult airway situations.
This document provides an outline and overview of controlled hypotension during anesthesia. It begins with definitions and a brief history of controlled hypotension. It then discusses the principles and techniques of inducing hypotension, including pharmacological agents like sodium nitroprusside, nitroglycerin, beta blockers, and calcium channel blockers. It also covers non-pharmacological techniques like positioning and acute normovolemic hemodilution. Monitoring, fluid management, and postoperative care are also outlined. The document concludes with sample multiple choice questions related to controlled hypotension.
This document discusses SvO2 and ScvO2 monitoring. SvO2 measures oxygen saturation from blood in the pulmonary artery and requires a pulmonary artery catheter. It provides information about whole body oxygen utilization. A decreased SvO2 indicates increased tissue oxygen extraction, while an increased SvO2 demonstrates decreased extraction and adequate cardiac output to meet tissue needs. ScvO2 can be used as a surrogate for SvO2. Monitoring SvO2/ScvO2 can help guide resuscitation and understand if oxygen delivery meets demand, but risks are associated with pulmonary artery catheters and values must be interpreted in clinical context.
This document discusses anesthesia considerations for bariatric surgery. It begins with definitions of obesity classifications based on BMI. It then discusses the increased risks that obese patients face from cardiovascular and pulmonary complications. Key points in the anesthetic management include careful preoperative evaluation and optimization of comorbidities, strategies for airway management and ventilation given the increased risk of difficulties, appropriate patient positioning and monitoring during surgery, and thromboprophylaxis given the risk of VTE. Overall anesthetic goals are to prevent hypoxemia and carefully manage any cardiovascular or pulmonary issues.
This document discusses the anesthetic considerations and complications related to laparoscopic surgeries. It notes that laparoscopy requires increased intra-abdominal pressure from insufflation of carbon dioxide gas, which can affect cardiovascular and respiratory physiology. The anesthesiologist must monitor for and manage increases in carbon dioxide levels as well as potential complications like gas embolism, pneumothorax, subcutaneous emphysema, and hemodynamic changes due to patient positioning. Proper preoperative evaluation, intraoperative monitoring, and postoperative care can help prevent or address issues arising from laparoscopic procedures.
This document presents the case of a 43-year-old male who underwent CABG surgery due to significant instent stenosis in his LAD artery. He experienced severe hypotension, ST elevation, and conduction defects post-operatively despite maximal medical and invasive management. The document reviews the pathophysiological effects of cardiopulmonary bypass that may have contributed to his condition, including systemic inflammatory response syndrome and vasoplegic syndrome. It also outlines his critical status in the cardiac ICU and the challenges in managing his circulatory failure, arrhythmias, organ dysfunction, and open sternum.
A 41-year-old female presented with right upper quadrant abdominal pain and was diagnosed with symptomatic gallstones and acute cholecystitis. She underwent a laparoscopic cholecystectomy under general anesthesia. General anesthesia was induced and tracheal intubation was performed. Pneumoperitoneum was created and maintained at 12 mmHg during the laparoscopic procedure. The surgery was completed without complications and the patient was extubated and transferred to the recovery unit in a stable condition.
Laparoscopic surgery involves insufflating the abdominal cavity with gas to provide space for visualization and instruments. Anesthesia aims to minimize the cardiovascular and respiratory effects of pneumoperitoneum and positioning. General anesthesia is most common to protect the airway and control gas flow. Care is taken with patient positioning, gas selection, and addressing risks like gas embolism, pneumothorax, or nerve injury. Special considerations exist for laparoscopy in children, pregnancy, and gasless techniques.
1) Laparoscopic surgery involves risks from insufflation of carbon dioxide into the peritoneum, which can cause cardiovascular and respiratory effects.
2) The anesthesiologist must carefully monitor the patient and choose an appropriate anesthetic technique to accommodate the physiological changes during laparoscopy and allow for early detection of potential complications.
3) While laparoscopy may offer advantages over open surgery, more research is still needed to determine whether the stress response and postoperative recovery is truly less than open procedures, especially for longer surgeries.
The document discusses several common acute complications that can occur during hemodialysis treatments. It notes that hypotension occurs in 25-55% of patients and is the most frequent complication. Other common complications include muscle cramps (5-20% of patients), nausea/vomiting (5-15%), chest pain (2-5%), and back pain (2-5%). The document provides details on the causes, risk factors, prevention, and treatment of these complications, particularly hypotension and muscle cramps. It also discusses less common but potentially life-threatening issues like dialysis disequilibrium syndrome, air embolism, and seizures.
Anesthesia for non cardiac surgery in adults with Congenital Heart DiseaseAnkita Patni
This document discusses anaesthetic management considerations for adults with congenital heart disease undergoing non-cardiac surgery. It outlines common congenital heart defects seen in adults and their long-term consequences, including pulmonary hypertension, bleeding/thrombosis risk, heart failure, and dysrhythmias. It provides guidance on preoperative evaluation, intraoperative monitoring tailored to specific defects, management strategies for defects like Fontan circulation, and postoperative care focused on preventing complications in the ICU.
Portopulmonary syndrome and portal hypertension can result in two pulmonary complications - portopulmonary hypertension (POPH) and hepatopulmonary syndrome (HPS). Both conditions are caused by diminished hepatic clearance of vasoactive substances, which cause pulmonary vascular changes and hypoxemia. POPH results in elevated pulmonary pressures and right ventricular dysfunction, while HPS induces intrapulmonary shunting and hypoxemia. Liver transplantation can cure HPS but the effects on POPH are unpredictable. Anesthesiologists must carefully manage these patients during transplantation due to the risks of worsening hypoxemia and hemodynamic instability.
World Laparoscopy Hospital provides learning by doing. It provides real-world laparoscopic surgery experience by allowing the trainee to get hands-on directly with whatever surgeons are learning and developing a sense of empowerment. After taking this laparoscopic training course, surgeons and gynecologists can perform laparoscopic surgery them self on their patients with confidence.
The anesthetic problems during minimal access surgery
are related to the cardiopulmonary effects of pneumoperitoneum, carbon dioxide (CO2) absorption, extraperitoneal
gas insufflation, venous embolism, and inadvertent injuries
to intraabdominal organs. Optimal anesthetic care of
patients undergoing laparoscopic surgery is very much
important. Good anesthetic techniques facilitate riskfree surgery and allow early detection and reduction of
complications.
In young patients, fit for diagnostic laparoscopy, general
anesthesia is the preferred method and does not impose
any increased risk. Adequate anesthesia and analgesia
are essential and endotracheal intubation and controlled
ventilation should be considered. The pneumoperitoneum
can be created safely under local anesthesia provided that
the patient is adequately sedated throughout the procedure.
For successful laparoscopy under local anesthesia, intravenous (IV) medication for sedation should be given
The anesthetic problems during minimal access surgery are related to the cardiopulmonary effects of pneumoperitoneum, carbon dioxide (CO2) absorption, extraperitoneal
gas insufflation, venous embolism, and inadvertent injuries to intraabdominal organs.
This document discusses anesthesia management for laparoscopic assisted surgery. Some key points include:
- Laparoscopy has advantages over open surgery like shorter hospital stays and faster recovery, but can pose respiratory and cardiovascular risks under anesthesia.
- Maintaining adequate ventilation and oxygenation can be challenging due to absorption of carbon dioxide and positioning effects.
- Gas embolism is a serious risk if gas is directly injected into blood vessels, which can cause hypotension, arrhythmias and death if massive.
- Patient positioning like head-down can increase risks like elevated intracranial pressure and decreased cardiac output that anesthesiologists must manage closely.
preoperative evaluation for residents of anesthesia part 2mansoor masjedi
This document summarizes key points from a presentation on preoperative evaluation and management of patients with pulmonary and other medical conditions. Some important topics discussed include: evaluating asthma severity and control; differentiating causes of wheezing; COPD diagnosis and management; restrictive lung diseases; dyspnea workup; pulmonary hypertension; smokers and second-hand smoke exposure; diabetes; renal and liver diseases; coagulation disorders; neurologic issues; upper respiratory infections; obesity; allergies; fasting guidelines; postoperative pain management; and components of a thorough preoperative consultation.
Haemoglobinopathies thalassemia, prophyrias and sickle cell disease-Deepa Sinha
1. Sickle cell disease (SCD) is caused by a genetic mutation that causes red blood cells to take on a sickle shape, leading to anemia, pain crises, and other complications.
2. Patients with SCD face increased risks from surgery and anesthesia due to the underlying disease. Preventing hypoxia, hyperviscosity, and acidosis can help reduce complications.
3. Common postoperative complications in SCD patients include pain crises, acute chest syndrome, fever, and alloimmunization from transfusions which can lead to delayed transfusion reactions. Close monitoring and treatment are important.
Pulmonary hypertension is defined as a mean pulmonary arterial pressure of at least 25 mm Hg. It can be caused by various conditions and is classified accordingly. Idiopathic pulmonary hypertension has no known cause. It presents with dyspnea and right heart failure. Diagnosis involves right heart catheterization showing elevated pulmonary pressures. Treatment includes diuretics, vasodilators like calcium channel blockers, endothelin receptor antagonists, phosphodiesterase inhibitors, prostanoids, and sometimes atrial septostomy or lung transplantation for severe cases refractory to medical therapy. Prognosis depends on factors like functional status, hemodynamics, and response to treatment.
Seminar on laparoscopic surgery and its anaesthetic consideration1drsauravdas1977
Laparoscopic surgery presents several anesthetic challenges due to pneumoperitoneum and patient positioning. Pneumoperitoneum can cause respiratory, cardiovascular, gastrointestinal, and other physiological changes. Careful monitoring and management is needed to address issues like hypercarbia, hemodynamic instability, hypothermia, and rare but serious complications like gas embolism. While offering benefits over open surgery, laparoscopy requires an anesthetic approach tailored to each patient's health and the specific procedures being performed.
This document discusses critical care aspects of chronic hepatic failure. It covers complications like variceal hemorrhage, refractory ascites, spontaneous bacterial peritonitis, and hepatic encephalopathy that often require ICU admission. It describes treatments for these complications including pharmacologic, endoscopic, radiologic, and surgical options. It also discusses management of portal hypertension, variceal bleeding, ascites, hepatic encephalopathy, and other issues related to caring for patients with chronic liver disease in the intensive care setting.
CONGENITAL HEART DISEASE & ANAESTHESIA by Dr.Sravani VishnubhatlaDrSravaniVishnubhatl
1) Congenital heart defects are the most common birth defects, affecting 1 in 125 live births. They range from simple shunt lesions to complex defects involving multiple structures.
2) The anesthetic goals vary depending on the type of shunt (left-to-right vs right-to-left) and aim to balance systemic and pulmonary vascular resistances.
3) Preoperative evaluation and optimization is important. Regional techniques may be used when hemodynamically appropriate but general anesthesia allows better control of ventilation and hemodynamics for high risk surgery.
This document discusses the etiopathogenesis and management of preeclampsia. It begins by outlining recommendations for blood pressure measurement in pregnancy. It then covers the classification of hypertension in pregnancy and risk factors for preeclampsia. The document discusses the etiology of preeclampsia involving poor placentation leading to placental oxidative stress and endothelial dysfunction. Predictors of preeclampsia and the role of ultrasound are described. Management involves termination of pregnancy, with timing based on gestational age and severity of symptoms. Antihypertensive therapy aims to control blood pressure without dropping it too low.
Similar to Anaesthetic management of Robotic surgery (20)
Burn injuries cause significant damage and health issues globally. They are the fourth most common type of trauma worldwide, with nearly 200,000 deaths annually. Most burns occur in low to middle income countries that lack infrastructure to treat them. Burns damage skin tissue through heat, chemicals, electricity or other sources. They are classified based on the depth of tissue destruction. Proper assessment of burn severity and depth is important for treatment. Burn injuries can cause shock, fluid and electrolyte imbalances, and long-term metabolic changes like increased energy expenditure if not properly managed.
Bronchoscopy is a procedure that uses a thin, lighted tube to examine the airways in the lungs. It can be used for diagnostic and therapeutic purposes. A bronchoscope allows doctors to directly visualize the trachea and bronchi. Common uses include evaluating infections, tumors, bleeding, and retained secretions. Complications can include hypoxemia, arrhythmias, infection, and hemorrhage, especially in critically ill patients on mechanical ventilation. Flexible bronchoscopy is a valuable tool in the ICU for diagnosing and treating various pulmonary conditions and complications. Care is needed to minimize risks in high-risk patients.
This document describes the Bain's circuit breathing system. It has a 6mm inner tube to deliver fresh gas from the machine to the patient and a wider outer corrugated tube attached to a reservoir bag. During inspiration, fresh gas flows from the machine through the inner tube and outer tube to the patient. During expiration, fresh gas continues flowing into the system while expired gas gets mixed with it and flows back into the reservoir bag and outer tube. The APL valve vents excess gas to prevent overpressurization of the system. Tests are described to check the functionality of the Bain's circuit.
Antepartum hemorrhage (APH) refers to bleeding after 20 weeks of pregnancy. Causes include placenta previa, placental abruption, and cervical issues. Anesthetic considerations for delivery include preparing for potential hemorrhage, choosing regional or general anesthesia depending on the urgency and maternal status, and strategies to minimize blood loss such as uterotonics. Complications of massive hemorrhage like coagulopathy and Sheehan's syndrome also require management. The goal is to anticipate blood loss and be prepared for potential life-threatening issues from APH.
anesthetic effect in IOP surgery and its drugs actionZIKRULLAH MALLICK
1. The document discusses the physiology of intraocular pressure, including production and drainage of aqueous humor and factors that regulate pressure.
2. It also reviews the effects of various anesthetic drugs on intraocular pressure, noting that most induction agents and inhalational anesthetics lower pressure while succinylcholine increases it briefly.
3. Proper management of intraocular pressure is important for open eye surgeries, and the anesthesiologist should aim for smooth induction, intubation, and avoidance of increases in central venous pressure that could raise pressure.
Anesthetic Considerations of Physiological Changes During Preg.pptZIKRULLAH MALLICK
During pregnancy, physiological changes alter the response to anesthesia. The respiratory system adapts to increased oxygen consumption through higher minute ventilation and respiratory drive. Cardiovascular changes include increased blood volume, heart rate, and stroke volume. Supine hypotension can occur due to compression of the inferior vena cava. Anesthetic agents readily cross the placenta and can depress the fetus, so doses must be carefully titrated. Labor further increases oxygen demand and the risk of supine hypotension due to uterine contractions displacing blood from the uterus into central circulation.
Smoking, alcoholism, and drug addiction can impact anesthesia care. Smoking increases risks of pulmonary and cardiovascular complications. Alcoholism can cause vitamin deficiencies, metabolic abnormalities, and liver or pancreatic damage. Drug abuse may cause pulmonary, cardiac, or CNS issues that worsen under anesthesia. When providing anesthesia for smokers, alcoholics, or drug abusers, their medical history must be thoroughly reviewed and precautions taken regarding airway management, hemodynamic stability, and potential withdrawal syndromes.
This document discusses anesthesia considerations for MRI and CT scans. It notes that sedation or anesthesia is often required for infants, uncooperative children, patients with movement or psychological disorders, and critically ill patients. The main challenges include using MRI-compatible monitoring equipment, limited access to patients, and treating medical emergencies safely outside of the scanner. Commonly used sedative agents include oral chloral hydrate, midazolam, and propofol administered with monitoring of ventilation.
This document provides an overview of the anatomy and nerve supply of the female birth canal. It describes the structures of the vulva including the labia majora, labia minora, clitoris, and vestibule. It then discusses the vagina, including its walls, structures, blood supply and nerve innervation. Finally, it summarizes the anatomy of the uterus, fallopian tubes, and ovaries including their blood supply, lymphatic drainage and nerve innervation.
ANAESTHETIC CONSIDERATION ON TRACHEOESOHAGEAL FISTULA .pptxZIKRULLAH MALLICK
- Tracheoesophageal fistula (TEF) is a birth defect where the trachea is connected to the esophagus. It occurs in about 1 in 3,000 live births and is more common in males.
- Anesthetic considerations for TEF surgery include the potential for aspiration, difficulty with intravenous access, the need for careful intubation to prevent ventilating the stomach, and the risk of associated cardiac or other anomalies.
- After surgery, the infant may require postoperative ventilation support and careful monitoring to prevent complications like airway obstruction or inadequate pain management.
age related changes in cvs and respiratory system.pptxZIKRULLAH MALLICK
The document discusses age-related anatomical and physiological changes in the cardiovascular and respiratory systems and their implications for anesthesia. Some key points:
- Both systems undergo progressive changes with age, including loss of elasticity, thickening, and structural/functional decline.
- In the cardiovascular system, this includes increased arterial stiffness, reduced heart function/reserve, and alterations to heart rate/rhythm.
- In the respiratory system, changes involve reduced lung compliance and function.
- These anatomical and physiological changes are important for anesthesiologists to consider, as they can impact patients' responses and tolerances to anesthesia drugs and techniques. Close monitoring is important.
The document discusses acid-base equilibrium and homeostasis. It covers three key points:
1. Homeostatic mechanisms tightly regulate the tonicity, volume, and specific ion concentrations of the interstitial fluid to maintain life. Buffers like bicarbonate and proteins also help regulate pH.
2. Acid-base equilibrium involves the dissociation of carbon dioxide and bicarbonate in body fluids. The Henderson-Hasselbalch equation relates pH to the bicarbonate and carbon dioxide levels.
3. The body maintains acid-base balance through buffering, compensation, and correction mechanisms. Pulmonary and renal systems compensate for changes in pH through ventilation and bicarbonate re
Physiological functions of liver - and liver function testZIKRULLAH MALLICK
The liver performs many critical physiological functions:
1. It regulates carbohydrate, lipid, and protein metabolism, producing glucose and ketone bodies and breaking down toxins.
2. The liver synthesizes proteins involved in blood clotting and transports iron, vitamins, and hormones.
3. The liver metabolizes and detoxifies drugs and other xenobiotics through phase I and phase II reactions and transports them out of the body. Impairment of these functions can lead to drug accumulation and toxicity.
Journal club covid vaccine neurological complications ZIKRULLAH MALLICK
the risks of adverse neurological events following SARS-CoV-2 infection are much greater than those associated with vaccinations, highlighting the benefits of ongoing vaccination programs.
DIABETES MELLITUS- Preop, Intraoperative management and considerationsZIKRULLAH MALLICK
The document discusses the metabolic effects of anesthesia and surgery in diabetic patients, which can include increased insulin resistance, hyperglycemia, and ketosis. It provides guidance on pre-operative evaluation and management of diabetic patients, including glycemic control targets and insulin adjustment. The goals of perioperative management are to maintain glycemic control, prevent complications, and minimize the metabolic consequences of starvation and surgical stress.
The document summarizes key information about dopamine, including its discovery and functions as a neurotransmitter. It describes dopamine's effects at different doses when used intravenously as a drug. Low doses selectively activate dopamine receptors to increase renal and splanchnic blood flow. Intermediate doses stimulate heart rate and contractility through beta-1 receptors. High doses cause systemic and pulmonary vasoconstriction through alpha receptors. The document also discusses dopamine's clinical uses, administration, interactions, and adverse effects.
Digoxin is a cardiac glycoside purified from plants like foxglove. It is used to treat heart conditions like atrial fibrillation and heart failure. Digoxin works by inhibiting the sodium-potassium pump in cardiac cells, increasing intracellular calcium and strengthening contractions. Common side effects include cardiac arrhythmias. Factors like electrolyte abnormalities, drug interactions, and renal impairment can increase the risk of digoxin toxicity. Clinical features of toxicity include cardiac arrhythmias and gastrointestinal symptoms.
This document provides information on the drug diclofenac. It is a non-steroidal anti-inflammatory drug (NSAID) that was first synthesized in 1973 and used clinically starting in 1979. Diclofenac works by inhibiting cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation. It is available in oral, intravenous, topical and other formulations to treat pain and inflammation conditions. Common adverse effects include gastrointestinal issues and potential liver and kidney toxicity. Diclofenac use has also been linked to reduced vulture populations when administered to livestock in India. The document provides details on diclofenac's mechanism of action, pharmacokinetics, formulations, doses, clinical uses,
This document provides an overview of dexmedetomidine, an alpha-2 adrenergic agonist used for its sedative, analgesic, and sympatholytic properties. It discusses dexmedetomidine's mechanism of action, pharmacokinetics, clinical uses, dosing, side effects and drug interactions. Dexmedetomidine is a selective alpha-2 receptor agonist that provides sedation and analgesia without respiratory depression. It has various uses for anesthesia, analgesia, and ICU sedation. Common side effects include hypertension, bradycardia and hypotension.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central19various
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
8. PHYSIOLOGY OF ROBOTIC ASSISTED
PELVIC SURGERY
15 – 20 degree
Trendelenburg
PCWP > 18 mm Hg
CO fell by 1030%
12 mm Hg
Pneumoperitoneum
MAP increased 25%
CVP, MPAP, PCWP
unchanged
SVR increased 20%
HR, SV unchanged
Mesenteric, hepatic and
renal blood flow
decreased.
Cardiovascular Effects of Trendelenburg and
Pneumoperitoneum
9. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
45o Trendelenburg with Pneumoperitoneum for
robotic assisted pelvic surgery.
CVP, MPAP, PCWP doubled
Blood pressure increased by 25%
SVR initially increased, then normalized
HR, SV unchanged
RV and LV stroke work increased by 65%
10. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Elevation in filling pressures was associated with 25%
increase in
early transmitral flow (early passive LV filling before
atrial kick).
Preservation of isovolemic relaxation time and
deceleration time would indicate diastolic function is
well preserved.
Diastolic function as an early indication of ischemia
indicate increases in filling pressure, afterload and
stroke work are well tolerated.
Echocardiographic measures of left and right
ventricle function indicate preserved or slight
increase in stroke volume.
11. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Healthy nonanesthetized volunteers experienced
a rise in heart rate without significant change in
blood pressure or cardiac output.
Patients with underlying ischemic heart
disease saw a rise in blood pressure and
cardiac output with a fall in heart rate.
12. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Pulmonary Effects of Trendelenburg and
Pneumoperitoneum
Reduced total lung capacity, compliance and
increase airway pressures.
A 15 mm Hg pneumoperitoneum yields a 9 mm
Hg rise in intrathoracic pressure.
The diaphragm is shifted cephalad and FRC is
reduced more than 50%. Lung volume
approaches closing capacity with resultant
atelectasis and shunt.
Arterial oxygenation falls.
Minute ventilation must increase to offset
hypercarbia.
13. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Ventilation modes and respiratory variables during TrP
and PPN
Volume Control and Pressure Control at equal tidal
volumes.
Pressure Control yields better compliance and
lower airway pressures.
There were no statistically significant differences in
hemodynamics.
RR increased nearly 50% to maintain normal pCO2
levels.
14. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Effects of PEEP during TrP
and PPN
Application of 5 mm Hg PEEP
increases FRC, elevating
lung volumes above
closing capacity.
Less atelectasis.
Compliance improves.
Arterial oxygenation
improves.
Pneumoperitoneum with
addition of PEEP may
abruptly drop CO.
Acta Anaesthesiologica Scandinavica, 2005, 49, 778
783
15. PHYSIOLOGY OF ROBOTIC ASSISTED
PELVIC SURGERY
Abdominal Effects of Elevated Intraabdominal
Pressure and
Pneumoperitoneum
Blood is mobilized out of the abdominal viscera, causing
an acute increase in cardiac preload.
Blood flow through the mesenteric arteries decreases,
resulting in a slow gradual rise in mucosal pH related to gut
ischemia.
Portal vein, hepatic vein and hepatic tissue perfusion all
decrease with associated rise in transaminases.
Blood flow in both the renal cortex and medulla decreases with
resultant fall in urine output.
Elevated intraabdominal pressure may decrease return
through the IVC and may result in delayed drop off in cardiac
preload.
16. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Effect of Elevated Pressure Pneumoperitoneum on
Neurohormonal regulation.
Rise in vasopressin and norepinephrine.
Activation of reninangiotensin system.
17. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Cerebral Hemodynamics during steep Trendelenburg and
Pneumoperitoneum
Headdown positioning increases CVP and thus impairs
venous drainage of the head.
The elevation of hydrostatic forces can lead to an
increase in extracellular water and perivascular
edema.
Development of cerebral edema and elevations in ICP may
lead to increased cerebrovascular resistance and reduced
cerebral blood flow.
ICP may be further elevated by increases in cerebral blood
volume
related to hypercarbia.
Impedance of drainage of the lumbar venous system
secondary to the elevated intraabdominal pressure may
decrease reabsorption of CSF and lead to a rise in ICP.
18. PHYSIOLOGY OF ROBOTIC
ASSISTED PELVIC SURGERY
Intraocular Pressure Dynamics during steep Trendelenburg
and Pneumoperitoneum
Major determinants of IOP
Aqueous humor flow
Choroidal blood volume
CVP
Extraocular muscle tone
Intraoperative hypertension, hypercarbia, position
and elevation in CVP may lead to
elevated IOP.
21. ROBOTIC SYSTEM MALFUNCTION
Review of 1,914 reports of da Vinci malfunction reported
to FDA.
Instrument failures comprise the largest group.
Arcing
Fragmentation
Patient side cart malfunctions.
Console malfunction.
Endoscope malfunction.
23. COMPLICATIONS OF PNEUMOPERITONEUM
Subcutaneous Emphysema
Common ~5%.
Usually self limited.
Increases rate of CO2
uptake.
Progressive mixed
acidosis.
o Continued postoperative absorption.
Further investigation
Pneumothorax
Capnothorax
Pneumomediastinum
32. PREOPERATIVE
History and Physical Exam
General Medical Assessment.
Patient specific factors which may be of
concern with prolonged
pneumoperitoneum or extremes of
positioning.
Patient specific factors which may
contribute to a difficult procedure.
Testing, blood work and consent driven by
standard
process.
33. Nervous system evaluation
CVA
Aneurysm
Elevated ICP
Hydrocephalus, VP shunt
Head trauma
Ocular pathology
Glaucoma
Preexisting neuropathy or susceptibilities
Diabetes, chemotherapy, peripheral
vascular disease
Extremes of body size, surgery lasting
> 3 hours.
34. Cardiovascular
Evaluation
Cardiomyopathy
CAD or MI by history or symptoms
Angina
Untreated obstructive coronary
disease
Cardiac murmurs
Evaluated by Echo
Moderate or severe regurgitant
valvular lesions
Peripheral vascular disease
35. Pulmonary Evaluation
COPD
Bullous emphysema
Spontaneous pneumothorax
Reactive airway disease
Prolonged pneumoperitoneum is
contraindicated in moderate to severe
disease states.
36. Renal disease
Renal insufficiency
may benefit from protective
strategies.
Renal failure
Contraindication to prolonged
pneumoperitoneum.
37. Lithotomy and Trendelenburg positioning
For every one hour spent in lithotomy, risk of
nerve injury increases 100 fold.
Risks of compartment syndrome
Myopathy, Fibrates or statin use, Muscular calf,
PVD.
Lateral decubitus positioning
Cervical spine disease
Back pain, radiculopathy
38. Age
Increased risk of post operative ventilation (> 65
years old)
Increased risk of ICU admission
Obesity
Correlated with longer operative times.
Higher ventilatory pressures and risk of
barotrauma.
Lower intraoperative oxygenation.
Associated with OSA, airway difficulty, diabetes.
Diaphragmatic hernia
Coagulopathy
39. Patient specific factors making for a difficult
operation.
Morbid obesity
Adhesions
Prior surgery
Prior infection
Prior radiation
Procedure specific
40. PREOPERATIVE
stop all antiplatelet medications for 1 week
and ASA in radical prostatectomies
1 day before surgery should adhere to clear
liquid diet.
Night before use laxative suppositories.
Bowel prep not used.
NPO at midnight.
Psychological preparation
Should be aware of plan for early discharge.
Informed of known side effects and
complications which are within the realm of
normal and do not affect recovery or
discharge.
41. PREOPERATIVE
Blood Type and Antibody Screen.
Peripheral IV access x 2.
Premedication for multimodal
analgesia.
Antibiotic order.
Antigastric prophylaxis with Ranitidine and
sodium citrate.
42. CONDUCT OF ANESTHESIA
Monitors
Standard ASA monitors.
Orbicularis oculi twitch response is most
similar to the adductor pollicis in onset and
duration.
43. CONDUCT OF ANESTHESIA
Monitors for special circumstances
Invasive monitors are indicated with inexperienced
robotic programs or while a surgeon is
inexperienced with a particular procedure.
Arterial blood pressure monitoring is indicated for
patients with cardiac or pulmonary disease, with all
cystectomy or nephrectomy operations and
procedures planned for greater than four hours.
Central line placement for the purpose of
resuscitative drug administration warrant re-
consideration if robotic surgery is the appropriate
approach.
44. CONDUCT OF ANESTHESIA
Monitors for special circumstances
Cardiac output monitoring is indicated in
cardiomyopathy.
Esophageal doppler has been advocated by
several authors.
TransEsophageal Echocardiography is the most
advantageous monitor to add in the event of
unexpected hemodynamic collapse.
45. CONDUCT OF ANESTHESIA
Induction
Intubation
Avoid hemodynamic response to
laryngoscopy.
Note the depth of ETT relative to the carina.
Ensure endotracheal tube is well secured.
46. CONDUCT OF ANESTHESIA
General Endotracheal Anesthesia
Secure airway.
Controlled mechanical ventilation to properly
handle carbon dioxide absorbed through
pneumoperitoneum.
Continuous neuromuscular blockade until
robot is undocked.
Nitrous oxide +/.
Low dose opiod.
Neuraxial techniques not currently recommended.
Thoracic epidural is associated with earlier
return of bowel function and of benefit in
cystectomy with ileal conduit.
47. Once the robot is docked there is no further
repositioning of the patient or bed without undocking the
robot.
Care must be taken the patient is positioned well enough
to tolerate up to 9 hours in the final position.
48. POSITIONING
Sequence for Lithotomy –Steep Trendelenburg
positioning
Awake tucking of arms.
Induction and intubation.
Eyes padded. Tegaderm applied.
Orogastric tube passed and gut decompressed.
Ensure face will be clear of equipment;
protective padding placed if necessary.
Fingers protected from bed hinges.
Legs raised simultaneously to bilateral stirrups.
Apply nerve stimulator.
Apply the bean bag ensuring no pressure points created.
Test the security of patient to bed in steep TrP.
Visualize face at all times.
49. INTRAOPERATIVE MANAGEMENT
Ventilation
A fall in compliance will complicate ventilation in TrP.
Pressure Control Ventilation is recommended.
PEEP [5 cm H2O] is recommended.
Mild hyperventilation to avoid development of hypercarbia
and resultant metabolic and respiratory acidemia.
Suggested minute ventilation is 1215 L/min.
Alternatively use twice the prePPN minute ventilation.
All changes in minute ventilation should be made
through manipulation of respiratory rate, not tidal
volume.
ETCO2 should plateau by 1520 min.
Appropriate to correlate to ABG in at risk patients.
Anticipate endobronchial intubation or mechanical
obstruction in PPN.
50. INTRAOPERATIVE MANAGEMENT
Perfusion
Patients at risk of cardiomyopathy may benefit from
arteriovasodilators
ie nicardipine
Patients at risk of demand ischemia may benefit from alpha 2
agonist
ie clonidine or dexmeditomidine
Patients at risk of elevated intracranial pressure should be
protected
mannitol, fluid restriction, normocapnia.
Patients at risk of renal insufficiency should be protected
Mannitol, nicardipine infusion, warm insufflation.
Patients at risk of compartment syndrome should have calves
checked for tissue tugor and consider repositioning legs every
two hours.
51. INTRAOPERATIVE MANAGEMENT
Neuromuscular blockade
Absolute requirement for paralysis during
period which the robot is docked to the
patient.
Use of continuous infusion has been
advocated.
Monitoring of neuromuscular function by
train of four has been recommended.
53. INTRAOPERATIVE MANAGEMENT
Fluid Management
Excess fluid administration in steep TrP can lead to
facial edema with associated swelling of conjunctiva
and/or airway.
In prostatectomy, fluid restriction is warranted with
a goal of less than 1 liter IVF up to the completion
of the urethrovesical anastamosis.
After the urethrovesical anastamosis is
complete, liberalize fluid administration with the
goal of an additional 1 liter IVF by the end of
surgery.
Always discuss concerns regarding fluid status with
surgeon.
Have a lower than usual threshold for colloid
administration.
54. INTRAOPERATIVE MANAGEMENT
Other intraoperative issues.
Thromboprophylaxis
Elevation of the legs and placement to stirrups
raises the risk of DVT formation.
Intermittent Compression Devices lower DVT
risk and promote venous return to the heart
even with elevated intraabdominal pressure.
Preoperative SQ Heparin is standard practice
55. INTRAOPERATIVE MANAGEMENT
Other intraoperative issues.
Oral, facial and ocular burns have been associated with
regurgitation of stomach acid in TrP.
Orogastric decompression
H2 blockade
Carefully cover the eyes with Tegaderm.
Antiemetic prophylaxis.
Surgical Local Anesthetic
Trocar / port site infiltration 5 – 10 mL
Intraperitoneal installation 40 mL
Irrigation fluid and urine commonly overwhelm blood in
the suction canisters making estimating blood loss
difficult.
56. PNEUMOPERITONEUM
Recommendations state “to use the lowest IAP allowing
adequate exposure … to avoid more than 12 mm Hg combined
with Trendelenburg positioning because it reduces pulmonary
compliance … and worsens ventilationperfusion impairment.”
Low pressure 57 mm Hg
Splanchnic perfusion preserved.
Normal 12 mm Hg
High 1520 mm Hg;
may be enacted to tamponade venous bleeding.
Anticipate bradycardia [asystole] with raising
pneumoperitoneum and initial placement of ports.
Reassess for bilateral breath sounds to exclude
endobronchial intubation.
57. EMERGENCY PLANNING
Have a low threshold for advanced monitoring and
arterial blood gas analysis.
Cardiovascular instability warrants immediate
termination of PPN and TrP and, if refractory,
investigation with transesophageal echo.
Advocate for aborting or suspending robotic
technique if signs indicate patient is not tolerating
steep TrP.
Have a plan for management of massive hemorrhage.
Be prepared to emergently undock robot.
It is acceptable to cardiovert with the robot docked.
58. PREPARING FOR EMERGENCE
Terminate neuromuscular blocker administration
once the robot is undocked.
Use “sigh” breath or recruitment maneuvers to
reverse interval atelectasis from PPN or
endobronchial intubation.
Elevate the patient’s head as soon as is permissible.
Maintain mechanical ventilation and
hyperventilation until the patient awakens.
59. EXTUBATION
Anticipate a delay in awakening.
Elevate the head of bed.
Assess for subcutaneous emphysema.
Assess for head and neck swelling, and scleral and
periorbital edema.
Perform endotracheal tube cuff “leak test”.
Ensure patient is following commands.
Auscultate for clear, bilateral breath sounds.
Ensure return of neuromuscular function.
If in any doubt of appropriate wakefulness, adequacy of
ventilation, or ability to maintain a patent airway - do not
extubate.
60. POSTOPERATIVE
Standard monitors for recovery of general
anesthesia.
Maintain elevation of the head of bed.
Hemoglobin analysis is indicated.
Blood gas analysis is indicated in the presence of
hypoxia, delirium, hyperventilation or as follow up to
intraoperative ABG abnormality.
Chest radiographs are indicated when significant
subcutaneous emphysema is present, or if there
are signs suggesting pneumothorax, or
unexplained low oxygen saturations.
61. POSTOPERATIVE
Patients should require little additional narcotic.
Reported pain should be evaluated as
consistent with procedure, referred from
phrenic nerve irritation, or related to
intraoperative positioning.
Moderate or severe pain should prompt
evaluation by surgeon.
Mental status should be evaluated to
rule out hypercarbia, elevated intracranial
pressure and stroke.
Positional neuropathies if any, need to be looked
into.
Oliguria should be promptly treated with 500 mL
bolus of crystalloid and then continue at150 mL/Hr.
62. Chief Concerns for Anesthesia during Robotic
Assisted Surgery
Limitation of access.
Inexperience of surgeon, assistants or team.
Extremes of patient positioning.
Length of case.
Hypothermia.
Respiratory and hemodynamic effects of
pneumoperitoneum and
extremes of positioning.
Occult blood loss.
Unsuspected visceral injury.