The document summarizes climate change impacts and deforestation effects on the Amazon region's water cycle. It notes the Amazon Basin's extraordinary biodiversity but also describes increasing droughts and floods in recent decades. Deforestation levels and air temperatures are also rising in southern Amazonia. Climate and land cover changes could significantly affect both regional and global water cycles. Modeling shows deforestation impacts local and regional hydroclimatic connectivity between the Amazon and Andes. Conserving and restoring terrestrial and aquatic systems, along with scientific innovation, education, and governance strengthening, are needed to support a sustainable Amazon region.