Hunter syndrome and its ayurveda view #mucopolysaccharidosis type II #MPS II #Hunter syndrome

1. Hunter syndrome and its
Ayurveda View
BY : Dr. V. K. Pathak

2. Introduction
• Hunter syndrome, or mucopolysaccharidosis type II (MPS II)
• X-linked lysosomal storage disease caused by mutations of the gene encoding the lysosomal enzyme
iduronate-2-sulfatase
• Deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S) causes accumulation of Large sugar
molecules called glycosaminoglycans (or GAGs or mucopolysaccharides) in body tissues.
GAG 1 GAG 2
GAG 1
GAG 2
Accumulation
of GAG
O linked sulfates
Iduronate-2-sulfatase

5. Symptoms

8. diagnosis
• Urinary GAG’s analysis
• Enzyme activity testing in plasma
• Genetic testing
• Prenatal screening

9. Treatment
• Enzyme replacement therapy
• Symptom based therapy

10. Jatharagni, Bhootagni, Dhatwagni
Mandya
Formation of Aam
Accumulation of Aam
Diasease symptoms
Agni Vardhan Sodhan
Basti Kayavirechan

11. THANK YOU