The document discusses the effects of aging on the periodontium. As people age, the periodontal tissues experience thinning of the gingival epithelium and decreased vascularization. The number of fibroblasts and collagen fibers in the periodontal ligament and gingiva decreases with age. Cementum width increases with age through continued deposition. Alveolar bone mass is reduced and bone formation decreases in older individuals. While the immune response is generally maintained with age, plaque accumulation and pathogens shift. Systemic conditions like diabetes can further impact the aging periodontium.
Periodontitis is a chronic infectious inflammatory disease caused by microbes; however the presence of microbes is not enough for the cause of its complex nature of disease. Inflammation is the prime cause of periodontal disease. It commences with the aggregation of pathogenic microbes that induce the host to stimulate a cascade of inflammatory response reactions which in-turn leads to the destruction of the host tissues itself. There is a complex interplay of innate and adaptive immune responses which fights against the pathogens by direct interaction or by release of certain molecules including cytokines.
Cytokines are cell signalling molecules that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma. Cytokine biology reveals that there are some subsets of cytokines which are pro-inflammatory cytokines which stimulate the inflammatory responses and cause tissue destruction.
A periodontist is expected to have a sound basis of the cytokine profile to understand the pathogenesis of periodontitis and also to discover the new treatment modality of anti-cytokine therapy.
Systemic Peridoontology, link between systemic health and periodontology, diabetes and periodontology, Pregnancy and Peridotology,Nutrition and periodontology
this ppt depicts pattern of bone destruction. its a very good slide show showing the process of bone formation, bone destruction and their patterns in periodontal diseases.
The future of dentistry and periodontics lies in regeneration. The goals of periodontal therapy lies in not only the arrest of periodontal disease progression but also regeneration of the lost periodontal structures. This presentation provides a review of the current understanding of the regeneration of the periodontium and the procedures involved to restore the periodontal tissues around the teeth.
Periodontitis is a chronic infectious inflammatory disease caused by microbes; however the presence of microbes is not enough for the cause of its complex nature of disease. Inflammation is the prime cause of periodontal disease. It commences with the aggregation of pathogenic microbes that induce the host to stimulate a cascade of inflammatory response reactions which in-turn leads to the destruction of the host tissues itself. There is a complex interplay of innate and adaptive immune responses which fights against the pathogens by direct interaction or by release of certain molecules including cytokines.
Cytokines are cell signalling molecules that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma. Cytokine biology reveals that there are some subsets of cytokines which are pro-inflammatory cytokines which stimulate the inflammatory responses and cause tissue destruction.
A periodontist is expected to have a sound basis of the cytokine profile to understand the pathogenesis of periodontitis and also to discover the new treatment modality of anti-cytokine therapy.
Systemic Peridoontology, link between systemic health and periodontology, diabetes and periodontology, Pregnancy and Peridotology,Nutrition and periodontology
this ppt depicts pattern of bone destruction. its a very good slide show showing the process of bone formation, bone destruction and their patterns in periodontal diseases.
The future of dentistry and periodontics lies in regeneration. The goals of periodontal therapy lies in not only the arrest of periodontal disease progression but also regeneration of the lost periodontal structures. This presentation provides a review of the current understanding of the regeneration of the periodontium and the procedures involved to restore the periodontal tissues around the teeth.
As age affect the our body parts similary it also affect the periodontium. To treat people with different age efficiently we need to understand the changes associated with periodontim.
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2. Contents
Introduction to Aging
General Effects of aging
Effect of aging on periodontium
• Gingival epithelium
• Gingival connective tissue
• Periodontal ligament
• Cementum
• Alveolar Bone
• Bacterial plaque
• Immune response
Systemic diseases & Periodontal health
Conclusion
4/30/2018 2
3. Introduction
• The process of becoming older, a process that is genetically
determined and environmentally modulated.1
• It includes the complex interaction of biologic, psychologic, and
sociologic process over time.
• Thus, in contrast to the chronological milestones which mark
life stages in the developed world, old age in many developing
countries is seen to begin at the point when active contribution
is no longer possible." (Gorman, 2000)
4/30/2018 3
1. Webster's New World™ Medical Dictionary, 3rd Edition.
4. • The geriatric population has been growing fast over the last
decades all over the world, changing demographics.
• Changes in biochemical and physiological processes occur with
aging in all body tissues, including the periodontium.
• Human ageing induces histo-physiological and clinical
alterations in oral tissues.2 (Mombelli A. 1998)
• These alterations must be understood to differentiate
pathological conditions from the altered physiology of oral
tissues resulting from ageing .3
4/30/2018 4
2. Mombelli A. Ageing and the periodontal and peri-implant microbiota. Periodontol 2000. 1998; 16: 44-52.
3. Savitt ED, Kent RL. Distribution of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis by subject age. J
Periodontol. 1991; 62: 490-494.
5. General effects of aging
4/30/2018 5
External
Hair Brittle, Less Abundant, Gray
Skin Dehydration, Decreased Elasticity, Thermo Sensitive
Eyes Diminished Vision, Enopthalmos
Nose Diminished Sense Of Smell
Secretory Glands Diminished Epithelial Activity
6. Internal
Renal Decreased renal blood flow Leading to water retention,
Difficulty in removing waste products.
Vascular Rise in systolic blood pressure
GIT Constipation and gas accumulation due to hypotonic
musculature.
Gonads Decrease estrogen and androgen secretion
Liver Decrease hepatic function
Pancreas Decrease function (diabetes)
4/30/2018 6
7. Alternations in oral motor functions
Lip posture Drooling, angular cheilitis.
Muscles of
mastication
Efficiency of Mastication decreases.
Tongue Speech, dysphagia, traumatic bite injury.
Swallowing Dysphagia
Taste Loss of sensation or decreased sensation.
4/30/2018 7
8. Age dependent changes in periodontal tissues
• The tissues that support the teeth are called the periodontium,
which consists of gingiva, periodontal ligament, cementum, and
alveolar bone.
• Anatomical and functional changes in periodontal tissues have
been reported as being associated with the ageing process.4 (Van
der Velden, 1984)
4/30/2018 8
9. Changes within gingival epithelium
• Thining of epithelium & diminished keratinization.5
• Increased epithelial permeability to pathogens.
• Decreased resistance to functional trauma.
• Rate of cell division in the basal layer of gingival epithelium has
not been shown to alter with increasing age.
4/30/2018 9
5. Needleman I. Envelhecimento e o periodonto. In: Newman MG, Takei HH, Carranza FA. Periodontia clínica. 9.ed. Rio de
Janeiro: Guanabara Koogan; 2004. p.51-5
10. • Cellular turnover rate slows down, leading to decline in the
production of both young cells and fibers in the gingiva.
• Epithelial density has been shown to be increased with age.
(Ryan 1974)
• Conflicting results have been reported regarding the shape of
the retepegs.
• A flattening of rete pegs and an increase in the height of the
epithelial ridges associated with ageing were both
demonstrated.
4/30/2018 10
11. Gingival sample obtained
from a 25-year-old healthy
subject. Normal aspect of
epithelium layers, rete ridges
and connective tissue, (HE
staining, ×10).
Gingival sample obtained
from a 66-year-old subject.
Thickening of epithelium
due to acanthosis (HE
staining, ×10).
Rom J Morphol Embryol 2013, 54(3 Suppl):811–815
4/30/2018 11
12. • In a morphological 3-dimensional study of the epithelium-
connective tissue interface, connective tissue ridges were
observed to be more prevalent in young individuals whereas
connective tissue papillae were predominant in old individuals.
• The change from ridges to papillae involves the formation of
epithelial cross-ridges with advanced age.4
4/30/2018 12
4. Van der Velden U. Effect of age on the periodontium. J Clin Periodontol. 1984; 11:
281 -294.
13. • The effect of aging on location of junctional epithelium has
been the subject of much speculation.
• The apical migration of the junctional epithelium, with
consequent gingival recession.
• Gingival recession progression may occur due to several factors,
such as passive eruption caused by physiological wear of teeth,
a consequence of anatomically thin tissues and tooth brushing
trauma.
4/30/2018 13
15. • Apparently, gingival recession is not an avoidable physiological
process caused by aging, but a cumulative and progressive
effect from periodontal disease or trauma over time.5
(Needleman 2004)
4/30/2018 15
5. Needleman I. Envelhecimento e o periodonto. In: Newman MG, Takei HH, Carranza FA. Periodontia clínica. 9.ed. Rio de
Janeiro: Guanabara Koogan; 2004. p.51-5
16. Changes within gingival connective tissue
• Coarser and denser gingival connective tissue.
• Qualitative and quantitative changes to collagen include;
• increased rate of conversion of soluble to insoluble collagen.
• increased mechanical strength.
• increased denaturation temperature.
• These results indicate increased collagen stabilization caused by
the changes in the macromolecular conformation.
• There is also a reduction in the organic matrix production and in
vascularization, and an increase in the number of elastic fibers.
4/30/2018 16
17. • Connective tissue - Number of cellular elements decreases as
age increases.
• The fibroblasts are the main cells in the synthesis of periodontal
connective tissue.
• In vivo and in vitro studies have shown functional and structural
alterations in fibroblasts associated with ageing.6-8
• Reduction in the number of fibroblasts in the periodontal
ligament and also in its functional activity.
4/30/2018 17
6. Abiko Y, Shimizu N, Yamaguchi M, Suzuki H, Takiguchi H. Effect of ageing on functional changes of periodontal
tissue cells. Ann Periodontol. 1998; 3: 350-369.
7. Dumas M, Chaudagne C, Bont F, Meybeck A. In vitro biosynthesis of type I and III collagens human dermal
fibroblasts from donors of increasing age. Mech AgeingDev. 1994; 73: 179-187.
8. Lee W, McCulloch CA. Deregulation of collagen phagocytosis in ageing human fibroblasts: effects of integrin
expression and cell cycle. Exp Cell Res. 1997; 237: 383-393.
18. • Gingival fibroblasts (GF) are constantly affected by oral
bacteria and their products, such as the lipopolysaccharides
(LPS), present in their cell walls.
• The LPS induces GF to release some inflammatory cytokines
• The influence of these inflammatory mediators - both GF and
periodontal ligament fibroblasts (PLF) - the severity of
periodontal disease.6
4/30/2018 18
19. Changes in Periodontal Ligament
• Decreased number of fibroblasts.
• Decreased organic matrix production.
• Decreased epithelial cell rests.
• Decreased number of collagen fibers.
↓
reduction or loss in tissue elasticity
• Vascularity reduces with age.
4/30/2018 19
20. • Cells of PDL have reduced mitotic activity.
• Thickness of the periodontal ligament varies and may reduce
due to the reduction in the force applied by masticatory muscles
along the time in subjects with complete dentition or having
dental elements with no antagonist.10 (Marsillac M, 2005)
• On the other hand, when several elements are missing, there
might be an overload on the existing remaining teeth, with
consequent periodontal ligament thickening.11 (Zenobio EG,
2004)
4/30/2018 20
10. Marsillac MWS, Mello HSA. Doença periodontal em idosos. In: Mello HSA. Odontogriatria. São Paulo: Santos; 2005.
p.107-14.
11. Zenóbio EG, Toledo BEC, Zuza EP. Fisiologia, patologia e tratamento das doenças do periodonto do paciente geriátrico.
In: Campostrini E. Odontogeriatria. Rio de Janeiro: Revinter; 2004. p.184-98.
21. Changes within the cementum
• Increase in cemental width is a common finding.
• Berglundh T. - study on dogs - Increase may be 5 to 10 times
with increasing age.12
• Van der Velden - Increase in width is greater apically and
lingually.13
• Deposition takes place mainly in apical region to compensate
for the physiological wear of teeth.
4/30/2018 21
12. Berglundh T. Clinical & structural characteristics of periodontal tissues in young & old dogs. J Clin Periodontol
18:616;1991.
13. Van der Velden u. Effect of age on periodontium. J Clin Periodontol 11:81;1984.
22. 4/30/2018 22
• Saverson et al. (1958) – Greater
cemental apposition in the apical region
is a response to the passive eruption of
the tooth.
• According to Ive et al. (1980), passive
eruption and migration of teeth involves
re- attachment of fibers between the
cementum and the periodontal ligament.
Increased cemental deposition might be
required to fulfil this.
• With advancing age, areas of cementum resorption followed by new
cemental apposition may be observed.
• This may result in irregular surface of cementum.
23. Changes in Alveolar bone
• Reduction of bone mass.
• More irregular periodontal surface of
bone.
• Less regular insertion of collagen
fibers.
• Increased bone resorption.
4/30/2018 23
24. • The reduction in bone formation might be due to a decrease in
osteoblast-proliferating precursors or to decreased synthesis
and secretion of essential bone matrix proteins.6
• The extracellular matrix surrounding osteoblasts has been
shown to play an important role in bone metabolism.
• A possible dysfunction of this matrix might occur
concomitantly with the ageing process.14
4/30/2018 24
6. Abiko Y, Shimizu N, Yamaguchi M, Suzuki H, Takiguchi H. Effect of ageing on functional changes of periodontal tissue
cells. Ann Periodontol. 1998; 3: 350-369.
14. Roholl PJM, Blauw E, Zurcher C, Dormans J, Theuns HM. Evidence for a diminished maturation of pre-osteoblasts into
osteoblast during ageing in rats: an ultrastructural analysis. J Bone Miner Res. 1994; 9: 355-366.
25. • Oxygen-free radicals have been reported to cause cellular
damage and, consequently, contribute to the ageing process.15,16
• In an in vitro study, oxygen radical-treated fibronectin (FN) was
found to inhibit bone nodule formation by osteoblasts when
compared to intact FN.
• This finding suggested that intact FN plays an important role in
osteoblast activity.
• FN damaged by oxygen radicals during the ageing process
might be related to less bone formation.
4/30/2018 25
15. Selkoe DJ. Deciphering Alzheimer’s disease: the amyloid precursor protein yields new clues. Science 1990; 248:
1058-1060.
16. McCord JM. Free radicals and inflammation:protection of synovial fluid by superoxide dismutase. Science 1974;
185: 529-531.
26. • Although age is a risk factor for the reduction of the bone mass
in osteoporosis, it is not causative and therefore distinguished
from physiologic aging process.
4/30/2018 26
27. Immune response
• Age has been recognized as having much less effect in
altering the host response.
• Difference between younger and older individuals can be
demonstrated for T and B cells, cytokines and natural killer
cells, but not polymorphonuclear cells and macrophages
activity.
4/30/2018 27
28. • McArthur17 concluded that “measurement of indicators of
immune & inflammatory competency suggested that, within the
parametes tested, there was no evidence for age related changes
in host defences correlating with periodontitis in an elderly
group of individuals, with and without disease.”
4/30/2018 28
17. McArthur WP. Effect of aging on immunocompetent and inflammatory cells . Periodontol 2000, 1999 : 16-
53.
29. Bacterial Plaque
• Dentogingival plaque accumulation increases with increase in
age.
• With increase in hard tissue surface area resulting from gingival
recession.
• The surface characteristics of the exposed root surface as a
substrate for plaque formation.
• Exposed cementum of the root surface and dental enamel
constitute two unlike types of hard dental tissues with distinct
surface characteristics, which may influence the plaque
formation rate differently.
4/30/2018 29
30. • For sub gingival plaque, increased number of entric rods and
pseudomonads in older adults. (Slots 1990)
• Periodontal pathogens specifically including an increased role
for P. gingivalis and decreased role for A.
actinomycetemcomitans.
4/30/2018 30
31. Association between periodontium and systemic
diseases
• Infectious diseases, such as periodontitis, cause inflammation
and contribute to levels of overall infection and inflammation in
the body and may trigger the beginning and/or the progression
of other diseases such as diabetes and arteriosclerosis.18
• There are two mechanisms through which infection and
inflammation apparently located in periodontal pockets may
harm general health:19
4/30/2018 31
The passage of periodontal
pathogens and their products
into circulation (bacteremia).
The passage of locally
produced inflammatory
mediators into circulation.
32. Diabetes Mellitus
4/30/2018 32JADA 2006;137(10 supplement):26S-31S.
Food Consumption
Breakdown of carbohydrates in
GIT and absorption of sugars
in bloodstream
Increased blood glucose
levels
Secretion of ꞵ- cells in
the pancreas
Insulin binds to target cell
receptors and allows entry of
glucose into the cell (used for
cellular energy)
Decreased blood
glucose levels
Type 1 Diabetes destroys ꞵ- cells
Type 2 Diabetes causes insulin
resistance at receptor and post
receptor levels
33. •It is suggested that the potential interactions between
diabetes and periodontitis seem to enhance the
morbidity of these two diseases.20
•The chronic hyperglycemic condition of diabetes is
associated with damage, dysfunction, or failure of
various organs and tissues, including the periodontium.
•It is due to the increased risk for infections in patients
with diabetes, impairment of the synthesis of collagen
and glycosaminoglycans by gingival fibroblasts, and
increased crevicular fluid collagenolytic activity,
Altered wound healing.21
4/30/2018 33
34. • It has been demonstrated by a meta-analysis study that patients
with types 1 and 2 diabetes had worse oral hygiene and higher
severity of gingival and periodontal diseases, compared to
nondiabetic subjects.22 (Khader YS. Et al. 2006)
• A multivariate risk analysis showed that subjects with type 2
diabetes had approximately threefold increased odds of having
periodontitis compared with subjects without diabetes, after
adjusting for confounding variables including age, sex and oral
hygiene measures.23 (Shlossman M. 2010)
4/30/2018 34
35. Coronary heart disease (CHD)
• Periodontal and cardiovascular diseases are common
inflammatory conditions in the human population,
atherosclerosis being the major component of the latter.
• Loesche et al. 2001 conducted a study on association between
periodontal disease and coronary heart disease.
• It was found that in patients with periodntal diseases there are
1.84 times more CHD.
4/30/2018 35
36. ROLE OF SUBGINGIVAL PLAQUE
4/30/2018 36
Subgingival plaque flora
Increased access to flora (compared to supra gingival plaque)
Via ulcerated epithelial lining of the pocket
Underlying connective tissue
Antimicrobial
potential in tissues
Cellular debris
Systemic circulation
Alterations in serum components of clotting
mechanisms
Elevated levels of fibrinogen
Risk of future coronary heart disease
Destroyed
37. • A meta-analysis study indicated that individuals with
periodontitis had 1.14 times higher risk of developing coronary
heart disease.24 (Bahekar AA 2007)
• The more severe the periodontal disease the easier the
periodontal pathogens could enter the circulation, reaching
blood vessels and atherosclerotic lesions.
4/30/2018 37
38. • Another linkage between periodontal disease and CHD is the
level of C-reactive protein, which is an acute-phase reactant in
response to infection or trauma and its high sustained level was
associated with advanced periodontitis.25 (Linden GJ 2008)
• Ridker et al. 2009 demonstrated that C-reactive protein levels
predict the risk of coronary events.26
4/30/2018 38
25. Linden GJ, McClean K, Young I, Evans A, Kee F. Persistently raised Creactive protein levels are associated with
advanced periodontal disease.J Clin Periodontol. 2008; 35: 741-7.
26. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the
prediction of cardiovascular disease in women. N Engl J Med. 2009; 342: 836-43.
39. PERIODONTAL TREATMENT PLANNING IN OLDER INDIVIDUALS
‘Goal of periodontal treatment is to preserve function and
prevent the progression of inflammatory disease’
- Factors must be considered in treatment planning
Patients
- General health status
- Medications
- Life style behaviors
- Ability to perform oral hygiene procedures
- Ability to tolerate treatment
- Amount of remaining periodontal support
4/30/2018 39
40. Operator side
- Decrease the length of surgical time
- Maintain open communication
- Minimize trauma
- Recalculate medication dosages
- Schedule morning appointment
- Non surgical approach – first treatment of choice.
- Surgical approach – depends on nature and extent of disease.
4/30/2018 40
41. Conclusion
• Aging dental patients have particular oral and general health
conditions that dentists should be familiar with detecting,
consulting and treating.
• Medical diseases and conditions that occur more often with age
may require modification to periodontal preventive tools as well
as the planning and treatment phases of periodontal care.
4/30/2018 41
42. References
1. Webster's New World™ Medical Dictionary, 3rd Edition.
2. Mombelli A. Ageing and the periodontal and peri-implant microbiota. Periodontol
2000. 1998; 16: 44-52.
3. Savitt ED, Kent RL. Distribution of Actinobacillus actinomycetemcomitans and
Porphyromonas gingivalis by subject age. J Periodontol. 1991; 62: 490-94.
4. Van der Velden U. Effect of age on the periodontium. J Clin Periodontol. 1984;
11: 281-94.
5. Needleman I. Envelhecimento e o periodonto. In: Newman MG, Takei HH,
Carranza FA. Periodontia clínica. 9.ed. Rio de Janeiro: Guanabara Koogan; 2004.
p.51-5.
6. Abiko Y, Shimizu N, Yamaguchi M, Suzuki H, Takiguchi H. Effect of ageing on functional
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Editor's Notes
Acanthosis- diffuse epidermal hyperplasis (thickening of skin).
Sol. To insol collagen – decreases the rate of collagen synthesis – prevents elimination from the body.
such as prostaglandin E2 (PGE2), interleukin (IL)-1, and plasminogen activator (PA) 6, 14.
Increased osteoporosis
reduced vascularity
Fewer fibres attached to bone and cementum
Increase in distance between crest of alveolar bone and CEJ
With increasing age, there is decrease in osteoblast proliferating precursors
Along with this, there is decreased secretion of essential bone matrix protiens (most important and predominant type 1 collagen)
This may lead to reduction in bone formation
Fibronectin is a glycoprotein of the extracellular matrix
It binds extracellular matrix components such as collagen, fibrin and heparan sulphate proteoglycans
Differences in dietary habits, increased flow of gingival exudate from the inflamed gingiva and possible age-related changes in salivary gland secretions may similarly alter the conditions for growth and multiplication of the plaque microorganisms
It has been speculated that a shift occours in the importance of certain periodontal pathogens with age
C-reactive protein (CRP) is a blood test marker for inflammation in the body. CRP is produced in the liver and its level is measured by testing the blood. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.