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Adaptive Noise Driven Total Variation
Filtering for Magnitude MR Image Denosing

Nivitha Varghees. V, M. Sabarimalai Manikandan & Rolant Gini
Outline


Introduction

MR

Image Denoising Methods

Proposed
Rician

Total Variation Filtering

Noise Estimation Scheme

Experimental
Conclusion

Results
Magnetic Resonance (MR)Imaging
non-invasive medical test that widely used by physicians
to diagnose and treat pathologic conditions
 provide clear and detailed structures of internal organs
and tissues of human body
 MRI to examine the brain, spine, cardiac, abdomen, pelvis,
breast, joints (e.g., knee, wrist, shoulder, and ankle), blood
vessels and other body parts
 MRI scanner uses powerful magnets and radio waves to
create pictures of the body
 The main source of noise in MRI images is the thermal
noise in the patient’s body [Now99].

Rician Noise in Magnitude MR Images
The raw MR data generated from a MRI machine are
corrupted by zero-mean Gaussian distributed noise with
equal variance
 In MR reconstruction, the spatial-domain complex MR
data are obtained from the frequency-domain raw MR
data by taking an inverse Fourier transform (IFT)
 For clinical diagnosis and analysis, the magnitude MR
data is constructed by taking the square root of the sum of
the square of the two real and imaginary data.
 The construction of the magnitude MR data transforms
the distribution of Gaussian noise into a Rician
distributed noise

Existing Image Denoising Methods
 Linear

models (e.g. Gaussian filter)

 Nonlinear
 DCT

models (e.g. Median filter)

and SVD filters

 Neighborhood

filters

 Non-Local

filters

 Multiscale

LMMSE

 Bilateral

filters

 Wavelet

transforms

 Total

variation (TV) filter
Performance of Existing Methods
 Gaussian

filter performs well in the flat regions of
images but do not well preserve the image edges.
 Transform based methods fail to reproduce image
details and often introduce artifacts
 Neighborhood filters may distort fine edges and local
geometries.
 Non-local estimation method over smooth out image
edges.
 Wavelet based hard thresholding scheme introduce
Gibbs oscillation near discontinuities.
Formulation of Total Variation Filtering
 Good

edge preserving capability
simultaneously removing noise

E(u) =








2

uz

2

while

 R(u )

: norm of a vector,

z : observed noisy data,
u: desired unknown image to be restored,
λ: regularization parameter,
R (u) : regularization functionals
Performance of TV Filtering for
Fixed Value of ʎ

Performance of the total variation filter for different values of regularization parameter
. (a) Original MRI image, (b) Image with Rician noise with σ= 10), (c) Restored image
with ʎ= 10, (d) Restored image with ʎ = 15, (e) Restored image with ʎ = 25, (f)
Restored image with ʎ= 40.
Proposed Total Variation Filtering
Noisy Image

Restored Image

ʎ
(a) Traditional TV Filtering Approach

Noisy Image

(ʎ)

Restored Image

(b) Propose Noise Level Driven TV Filtering Approach
Rician Distribution of Noisy MRI Data
The Rician probability density function (PDF) of the corrupted
magnitude MR image intensity m is given as

m2  A2  Am 
p(m A,  )  2 e
I 0  2  u (m),
2

2
 
m

where, Io denotes the 0th order modified Bessel
function of the first kind,
 σ2 is the noise variance in the MRI image,
 A is the signal amplitude of the clean image,
 m denotes the MR magnitude variable,
 u (.) is the unit step Heaviside function.

Noise Models for Rician Noise Estimation
 For

magnitude MR images with large
background, the Rician distribution is reduced to
a Rayleigh distribution with the probability
density function (PDF):
m2
p(m A,  )  2 e
u (m)
2

2
m





In the bright regions of the MR image where the
SNR is assumed to be large, the Rician
distribution can be approximated using a
Gaussian PDF:
Rician Noise Estimation Using Local
Variances


Variance of noise in magnitude MR image is
computed as

 the regularization parameter of TV is adapted based on

the estimated noise standard deviation for a given image
Performance of Rician Noise Estimator
36
34
32

estimated noise standard deviation, 

30
28
26
24
22
20
18
16
14
12
10
8
6
4
2
0

0

2

4

6

8

10

12

14

16

18

20

22

24

26

28

30

32

34

36

noise standnard deviation, n

Estimation of standard deviation of noise using the mode
of the locally estimated variance. • corresponds to the average of the
estimated standard deviations obtained for all test images for each noise
standard deviation.
Performance of Rician Noise Estimator
Performance of MRI Denoising Methods

(a) Original MR image. (b) MR image with Rician noise with standard
deviation σ= 20. (c) Restored image using proposed adaptive TV filtering
approach. (d) Restored image using the multi-scale LMMSE approach. (e)
Restored image using the non-local filtering approach. (f) Restored image
using the bilateral filtering approach.
Performance of MR Image Denoising Methods
σ=10

σ=15
MSE

σ=20
SSIM MOS

MOS

MSE

SSIM

MOS

MSE

SSIM

Noisy

4.3

130.3

0.506

2.3

303.8 0.37

1.3

551.7 0.29

1

874.4

0.24

NLM

4.8

79.6

0.639

4.3

180.1 0.55

3.7

326.9 0.49

3

522.7

0.45

Bilateral
filter
Multiscale
LMMSE
Proposed
Method

4.7

89.98

0.617

3.7

205.4 0.51

2.8

369.1 0.49

2.3

579.4

0.38

5

81.6

0.636

4.7

186.4 0.55

3.2

337.3 0.50

2.2

536.3

0.46

5

80.4

0.639

4.6

180.4 0.55

4.2

324.6 0.49

3.4

513.3

0.44

SSIM: Structural Similarity Measure
MSE: Mean Squared Error
MOS: Mean Opinion Score

MSE

σ=25
SSIM MOS
Conclusion









In this work, we studied the effect of regularization parameter
on TV denoising
Here, the regularization parameter is adapted based on the
noise level in magnitude MR images
The noise level is computed using local variances of image
The performance of different denoising algorithms such as
NLM, bilateral, multiscale LMMSE approach, and proposed
method is evaluated in terms subjective test and objective
mertics
Experiments showed that the proposed method provides
significantly better quality of denoised images as compared to
that of the existing methods
References


R. M. Henkelman, “Measurement of signal intensities in the presence of noise in MR
images,” Med. Phys., vol. 12, no. 2, pp. 232-233, 1985.



L. Kaufman, D. M. Kramer, L. E. Crooks, and D. A. Ortendahl, “Measuring signal-tonoise ratios in MR imaging,” Radiology, vol. 173, pp. 265-267, 1989.



G. Gerig, O. Kubler, R. Kikinis, and F. Jolesz. “Nonlinear anisotropic filtering of MRI
data,” IEEE. Trans. Med. Img., vol. 11, no. 2, pp. 221- 232, 1992.



H. Gudbjartsson and S. Patz, ”The Rician distribution of noisy MRI data,”Magnetic
Resonance in Medicine, vol. 34, no. 6, pp. 910-914, 1995.



A. Crdenas-Blanco, C. Tejos, P. Irarrazaval, and I. Cameron, “Noise in magnitude
magnetic resonance images,” Concepts in Magnetic Resonance, vol. 32, no. 6, pp. 409-416,
2008.



S. Aja-Fernandez, C. Alberola-Lopez, and C.-F.Westin, “Noise and signal estimation in
magnitude MRI and Rician distributed images: a LMMSE approach,” IEEE Trans. Image
Process., vol. 17, no. 8, pp. 1383-1398, 2008.
References


A.
Samsonov and C. Johnson. “Noise adaptive anisotropic diffusion filtering of
MR images with spatially varying noise levels,” Magn. Reson. Med., vol. 52, pp. 798806, 2004.



L. Rudin, S. Osher and E. Fatemi, “Nonlinear total variation based noise removal
algorithms,” Physica D, vol. 60, pp. 259-268, 1992.



R. Acar and C. R. Vogel, “Analysis of total variation penalty methods for ill-posed
problems,” Inverse Prob., vol. 10, 1217-1229, 1994.



A.
Chambolle and P. L. Lions, “Image recovery via total variational minimization
and related problems,” Numer. Math., vol. 76, pp. 167-188, 1997.



T. F. Chan, S. Osher, and J. Shen, “The digital TV filter and nonlinear denoising,” IEEE
Trans. Image Process., vol. 10, no. 2, pp. 231-241, 2001.



A. Buades, B. Coll, and J.-M. Morel, “A review of image denoising algorithms, with a
new one,” Multiscale Modeling and Simulatio, vol. 4, pp. 490-530, 2005.



A. Buades, B. Coll, and J.-M. Morel, “A non-local algorithm for image denoising,”
IEEE Proc. Comp. Visi. Pat. Recog., vol. 2, pp. 60-65, 2005.
References


P. Perona, and J. Malik, “Scale-space and edge detection using anisotropic diffusion,”
IEEE Trans. on Pattern Analysis and Machine Intelligence, vol. 12, no. 7, pp. 629-639, 1990.



J. Weickert, “Coherence-enhancing diffusion of colour images,” Image and Vision
Computing, vol. 17, pp. 201-212, 1999.



L. Zhang et al., “Multiscle LMMSE-based image denoising with optimal wavelet
selection, IEEE Trans. on Circuits and Systems for Video Technology, vol. 15, pp. 469-481,
2005.



A. Buades, B. Coll, and J. M. Morel “A non-local algorithm for image denoising,” IEEE
Computer Vision and Pattern Recognition (CVPR), vol. 2, pp. 60-65, 2005.



Z. Wang, A. C. Bovik, H. R. Sheikh and E. P. Simoncelli, “Image quality assessment:
From error visibility to structural similarity,” IEEE Trans. Image Process., vol. 13, no. 4,
pp. 600-612, 2004.
Adaptive noise driven total variation filtering for magnitude mr image denosing

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Adaptive noise driven total variation filtering for magnitude mr image denosing

  • 1. Adaptive Noise Driven Total Variation Filtering for Magnitude MR Image Denosing Nivitha Varghees. V, M. Sabarimalai Manikandan & Rolant Gini
  • 2. Outline  Introduction MR Image Denoising Methods Proposed Rician Total Variation Filtering Noise Estimation Scheme Experimental Conclusion Results
  • 3. Magnetic Resonance (MR)Imaging non-invasive medical test that widely used by physicians to diagnose and treat pathologic conditions  provide clear and detailed structures of internal organs and tissues of human body  MRI to examine the brain, spine, cardiac, abdomen, pelvis, breast, joints (e.g., knee, wrist, shoulder, and ankle), blood vessels and other body parts  MRI scanner uses powerful magnets and radio waves to create pictures of the body  The main source of noise in MRI images is the thermal noise in the patient’s body [Now99]. 
  • 4. Rician Noise in Magnitude MR Images The raw MR data generated from a MRI machine are corrupted by zero-mean Gaussian distributed noise with equal variance  In MR reconstruction, the spatial-domain complex MR data are obtained from the frequency-domain raw MR data by taking an inverse Fourier transform (IFT)  For clinical diagnosis and analysis, the magnitude MR data is constructed by taking the square root of the sum of the square of the two real and imaginary data.  The construction of the magnitude MR data transforms the distribution of Gaussian noise into a Rician distributed noise 
  • 5. Existing Image Denoising Methods  Linear models (e.g. Gaussian filter)  Nonlinear  DCT models (e.g. Median filter) and SVD filters  Neighborhood filters  Non-Local filters  Multiscale LMMSE  Bilateral filters  Wavelet transforms  Total variation (TV) filter
  • 6. Performance of Existing Methods  Gaussian filter performs well in the flat regions of images but do not well preserve the image edges.  Transform based methods fail to reproduce image details and often introduce artifacts  Neighborhood filters may distort fine edges and local geometries.  Non-local estimation method over smooth out image edges.  Wavelet based hard thresholding scheme introduce Gibbs oscillation near discontinuities.
  • 7. Formulation of Total Variation Filtering  Good edge preserving capability simultaneously removing noise E(u) =       2 uz 2 while  R(u ) : norm of a vector, z : observed noisy data, u: desired unknown image to be restored, λ: regularization parameter, R (u) : regularization functionals
  • 8. Performance of TV Filtering for Fixed Value of ʎ Performance of the total variation filter for different values of regularization parameter . (a) Original MRI image, (b) Image with Rician noise with σ= 10), (c) Restored image with ʎ= 10, (d) Restored image with ʎ = 15, (e) Restored image with ʎ = 25, (f) Restored image with ʎ= 40.
  • 9. Proposed Total Variation Filtering Noisy Image Restored Image ʎ (a) Traditional TV Filtering Approach Noisy Image (ʎ) Restored Image (b) Propose Noise Level Driven TV Filtering Approach
  • 10. Rician Distribution of Noisy MRI Data The Rician probability density function (PDF) of the corrupted magnitude MR image intensity m is given as m2  A2  Am  p(m A,  )  2 e I 0  2  u (m), 2  2   m where, Io denotes the 0th order modified Bessel function of the first kind,  σ2 is the noise variance in the MRI image,  A is the signal amplitude of the clean image,  m denotes the MR magnitude variable,  u (.) is the unit step Heaviside function. 
  • 11. Noise Models for Rician Noise Estimation  For magnitude MR images with large background, the Rician distribution is reduced to a Rayleigh distribution with the probability density function (PDF): m2 p(m A,  )  2 e u (m) 2  2 m   In the bright regions of the MR image where the SNR is assumed to be large, the Rician distribution can be approximated using a Gaussian PDF:
  • 12. Rician Noise Estimation Using Local Variances  Variance of noise in magnitude MR image is computed as  the regularization parameter of TV is adapted based on the estimated noise standard deviation for a given image
  • 13. Performance of Rician Noise Estimator 36 34 32 estimated noise standard deviation,  30 28 26 24 22 20 18 16 14 12 10 8 6 4 2 0 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 noise standnard deviation, n Estimation of standard deviation of noise using the mode of the locally estimated variance. • corresponds to the average of the estimated standard deviations obtained for all test images for each noise standard deviation.
  • 14. Performance of Rician Noise Estimator
  • 15. Performance of MRI Denoising Methods (a) Original MR image. (b) MR image with Rician noise with standard deviation σ= 20. (c) Restored image using proposed adaptive TV filtering approach. (d) Restored image using the multi-scale LMMSE approach. (e) Restored image using the non-local filtering approach. (f) Restored image using the bilateral filtering approach.
  • 16. Performance of MR Image Denoising Methods σ=10 σ=15 MSE σ=20 SSIM MOS MOS MSE SSIM MOS MSE SSIM Noisy 4.3 130.3 0.506 2.3 303.8 0.37 1.3 551.7 0.29 1 874.4 0.24 NLM 4.8 79.6 0.639 4.3 180.1 0.55 3.7 326.9 0.49 3 522.7 0.45 Bilateral filter Multiscale LMMSE Proposed Method 4.7 89.98 0.617 3.7 205.4 0.51 2.8 369.1 0.49 2.3 579.4 0.38 5 81.6 0.636 4.7 186.4 0.55 3.2 337.3 0.50 2.2 536.3 0.46 5 80.4 0.639 4.6 180.4 0.55 4.2 324.6 0.49 3.4 513.3 0.44 SSIM: Structural Similarity Measure MSE: Mean Squared Error MOS: Mean Opinion Score MSE σ=25 SSIM MOS
  • 17. Conclusion      In this work, we studied the effect of regularization parameter on TV denoising Here, the regularization parameter is adapted based on the noise level in magnitude MR images The noise level is computed using local variances of image The performance of different denoising algorithms such as NLM, bilateral, multiscale LMMSE approach, and proposed method is evaluated in terms subjective test and objective mertics Experiments showed that the proposed method provides significantly better quality of denoised images as compared to that of the existing methods
  • 18. References  R. M. Henkelman, “Measurement of signal intensities in the presence of noise in MR images,” Med. Phys., vol. 12, no. 2, pp. 232-233, 1985.  L. Kaufman, D. M. Kramer, L. E. Crooks, and D. A. Ortendahl, “Measuring signal-tonoise ratios in MR imaging,” Radiology, vol. 173, pp. 265-267, 1989.  G. Gerig, O. Kubler, R. Kikinis, and F. Jolesz. “Nonlinear anisotropic filtering of MRI data,” IEEE. Trans. Med. Img., vol. 11, no. 2, pp. 221- 232, 1992.  H. Gudbjartsson and S. Patz, ”The Rician distribution of noisy MRI data,”Magnetic Resonance in Medicine, vol. 34, no. 6, pp. 910-914, 1995.  A. Crdenas-Blanco, C. Tejos, P. Irarrazaval, and I. Cameron, “Noise in magnitude magnetic resonance images,” Concepts in Magnetic Resonance, vol. 32, no. 6, pp. 409-416, 2008.  S. Aja-Fernandez, C. Alberola-Lopez, and C.-F.Westin, “Noise and signal estimation in magnitude MRI and Rician distributed images: a LMMSE approach,” IEEE Trans. Image Process., vol. 17, no. 8, pp. 1383-1398, 2008.
  • 19. References  A. Samsonov and C. Johnson. “Noise adaptive anisotropic diffusion filtering of MR images with spatially varying noise levels,” Magn. Reson. Med., vol. 52, pp. 798806, 2004.  L. Rudin, S. Osher and E. Fatemi, “Nonlinear total variation based noise removal algorithms,” Physica D, vol. 60, pp. 259-268, 1992.  R. Acar and C. R. Vogel, “Analysis of total variation penalty methods for ill-posed problems,” Inverse Prob., vol. 10, 1217-1229, 1994.  A. Chambolle and P. L. Lions, “Image recovery via total variational minimization and related problems,” Numer. Math., vol. 76, pp. 167-188, 1997.  T. F. Chan, S. Osher, and J. Shen, “The digital TV filter and nonlinear denoising,” IEEE Trans. Image Process., vol. 10, no. 2, pp. 231-241, 2001.  A. Buades, B. Coll, and J.-M. Morel, “A review of image denoising algorithms, with a new one,” Multiscale Modeling and Simulatio, vol. 4, pp. 490-530, 2005.  A. Buades, B. Coll, and J.-M. Morel, “A non-local algorithm for image denoising,” IEEE Proc. Comp. Visi. Pat. Recog., vol. 2, pp. 60-65, 2005.
  • 20. References  P. Perona, and J. Malik, “Scale-space and edge detection using anisotropic diffusion,” IEEE Trans. on Pattern Analysis and Machine Intelligence, vol. 12, no. 7, pp. 629-639, 1990.  J. Weickert, “Coherence-enhancing diffusion of colour images,” Image and Vision Computing, vol. 17, pp. 201-212, 1999.  L. Zhang et al., “Multiscle LMMSE-based image denoising with optimal wavelet selection, IEEE Trans. on Circuits and Systems for Video Technology, vol. 15, pp. 469-481, 2005.  A. Buades, B. Coll, and J. M. Morel “A non-local algorithm for image denoising,” IEEE Computer Vision and Pattern Recognition (CVPR), vol. 2, pp. 60-65, 2005.  Z. Wang, A. C. Bovik, H. R. Sheikh and E. P. Simoncelli, “Image quality assessment: From error visibility to structural similarity,” IEEE Trans. Image Process., vol. 13, no. 4, pp. 600-612, 2004.