The document discusses early management of ischemic stroke. It defines stroke as a sudden neurological deficit of vascular origin lasting more than 24 hours. It emphasizes that "time is brain" and every minute of untreated stroke causes the loss of 1.9 million neurons. It outlines risk factors, signs and symptoms of different types of stroke, and the definition of transient ischemic attack. Current acute treatments for ischemic stroke including thrombolysis within 3-4.5 hours and aspirin within 48 hours are discussed.
Acute stroke management
IV thrombolysis guidelines
IV thrombolysis side effects
Early CT changes in stroke
ASPECTS scoring
AHA stroke guidelines
Thrombolysis controversies
Acute coronary syndrome result from a sudden blockage in a coronary artery. this blockage causes unstable angina or heart attack (MI), depending on the location and amount of blockage.
people who experience an ACS usually have chest pressure or ache, shortness of breath and fatigue.
People who think they are experiencing ACS should call for emergency help.
Doctors use ECG and blood test (troponin level) to determine whether a person is experiencing an ACS.
Treatment varies depending on the type of syndrome but usually include attempts to increase blood flow to affected area.
This includes scores, prehospital and emergency department management of stroke. it goes into details of stabilisation and general management. definitive management options are thrombolysis or thrombectomy. briefly described complications of stroke and management as well
Acute coronary syndrome is a term used to describe a range of conditions associated with sudden, reduced blood flow to the heart.
One such condition is a heart attack (myocardial infarction) — when cell death results in damaged or destroyed heart tissue. Even when acute coronary syndrome causes no cell death, the reduced blood flow changes how your heart works and is a sign of a high risk of heart attack.
Acute coronary syndrome often causes severe chest pain or discomfort. It is a medical emergency that requires prompt diagnosis and care. The goals of treatment include improving blood flow, treating complications and preventing future problems.
Acute stroke management
IV thrombolysis guidelines
IV thrombolysis side effects
Early CT changes in stroke
ASPECTS scoring
AHA stroke guidelines
Thrombolysis controversies
Acute coronary syndrome result from a sudden blockage in a coronary artery. this blockage causes unstable angina or heart attack (MI), depending on the location and amount of blockage.
people who experience an ACS usually have chest pressure or ache, shortness of breath and fatigue.
People who think they are experiencing ACS should call for emergency help.
Doctors use ECG and blood test (troponin level) to determine whether a person is experiencing an ACS.
Treatment varies depending on the type of syndrome but usually include attempts to increase blood flow to affected area.
This includes scores, prehospital and emergency department management of stroke. it goes into details of stabilisation and general management. definitive management options are thrombolysis or thrombectomy. briefly described complications of stroke and management as well
Acute coronary syndrome is a term used to describe a range of conditions associated with sudden, reduced blood flow to the heart.
One such condition is a heart attack (myocardial infarction) — when cell death results in damaged or destroyed heart tissue. Even when acute coronary syndrome causes no cell death, the reduced blood flow changes how your heart works and is a sign of a high risk of heart attack.
Acute coronary syndrome often causes severe chest pain or discomfort. It is a medical emergency that requires prompt diagnosis and care. The goals of treatment include improving blood flow, treating complications and preventing future problems.
This talk covers the most important aspects of treatment of acute ischemic stroke, such as thrombolysis, use of antiplatelets, BP and sugar control and general supportive care.
This is a short presentation at Down Town Hospital clinical meeting for DNB Medicine students. It dose not cover the all aspects of stroke care especially Thrombolysis, since it is difficult to practice for Medical specialist, and ischemic stroke is not common in North East India
Intracerebral hemorhage Diagnosis and managementRamesh Babu
About ICH - Diagnosis and management, Discussed the clinical presentation, evaluation, radiological features and management including recent guidelines
This talk covers the most important aspects of treatment of acute ischemic stroke, such as thrombolysis, use of antiplatelets, BP and sugar control and general supportive care.
This is a short presentation at Down Town Hospital clinical meeting for DNB Medicine students. It dose not cover the all aspects of stroke care especially Thrombolysis, since it is difficult to practice for Medical specialist, and ischemic stroke is not common in North East India
Intracerebral hemorhage Diagnosis and managementRamesh Babu
About ICH - Diagnosis and management, Discussed the clinical presentation, evaluation, radiological features and management including recent guidelines
Tom Bleck - Subarachnoid Hemorrhage: What Matters?SMACC Conference
Tom Bleck - Subarachnoid haemorrhage: what matters?
Tom Bleck gives an overview of the pertinent facts regarding the complications and management of aneurysmal subarachnoid haemorrhage (SAH).
The complications of aneurysmal SAH can be divided into immediate, early and late. The risk of re-bleeding is maximal on the first day, it is fatal in 75% of patients and the best management is to secure the aneurysm by coiling or clipping. Blood pressure control is utilised widely but parameters are arbitrary and the data is scarce.
Early complications (days 1 - 3) include early brain injury in its various forms, stress cardiomyopathy, neurogenic pulmonary oedema and cerebral salt wasting. The most important late complication (day 4 onwards) is vasospasm.
Tom briefly discusses the mechanisms and manifestations of SAH-associated brain injury including ischaemia, blood brain barrier breakdown, sustained depolarisation, hydrocephalus, vasospasm, seizures, hyperglycaemia and fever. He goes on to discuss in more detail the management of vasospasm, the associated evidence and the importance of distinguishing between clinically detectable and subclinical vasospasm.
Radiology of Brain hemorrhage vs infarctionthamir22
this presentaion is free for every medical student
by the end of this presentation you will be able to identify cerebral strokes and determine the age of the pathology
good luck .. Dr Thamir alotaify
2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment
Stroke. 2015;46:3020-3035.
cerebrovascular accident, commonly known as stroke is one of the most common health problems of the world. in the developing world, its increasing incidence is a matter of concern among the health workers across the globe. thus adequate knowledge about this medical condition is a must to deal with it effectively.
STROKE is also known as CVA. (cerebrovascular accident). it is a medical emergency. damage to the brain from interruption of its blood supply .early action can reduce brain damage and other complication.
signs and symptoms slur words or difficulty understanding speech.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Acute management of Stroke By Dr Sanjay jaiswal Neurologist sept2012
1. Early Management of
Ischemic Stroke
DR SANJAY JAISWAL, MD,DM
Member world stroke organization
Consultant Neurologist
Jaiswal Hospital and Neuro Institute
Kota ,Rajasthan.
2. Reference
Guidelines for the Early Management of
Adults With Ischemic Stroke Stroke
2007;38;1655-1711
Acute ischemic stroke N Engl J Med 2007;
357:572-579, Aug 9, 2007
3. Brain Attack!
Acute stroke = ‘brain attack’
Every minute matters: ‘time is
brain’
Combat therapeutic nihilism
4. Time is Brain…why?
The typical patient loses 1.9 million neurons each
minute in which stroke is untreated
The ischaemic penumbra
5. WHO DEFINITION OF STROKE
A NEUROLOGICAL DEFICIT OF
Sudden onset
With focal rather than global dysfunction
In which, after adequate investigations,
symptoms are presumed to be of non-traumatic
vascular origin
and last for >24 hours
6. New definition of TIA
A brief episode of neurological dysfunction
caused by focal brain or retinal ischaemia with
clinical symptoms lasting less than one hour
without evidence of infarction
8. Left MCA Syndrome
•Language loss (aphasia)
•Right hemiparesis
•Right hemisensory loss
•Right visual field cut
•Left gaze preference
9. Right MCA Syndrome
•Left hemi-neglect
visual,spatial,
•Left hemiparesis
•Left hemisensory loss
•Left visual field cut
•Neglect of deficits
“anasgnosia”
11. Vascular occlusion causes stroke symptoms
•50-70% of all stroke is due to embolism
(cardiogenic and artery-to-artery)
•80 % of acute strokes are due to MCA
territory ischemia
• Arterial occlusion is seen in 80-90%
within 6-24° of symptom onset
• Spontaneous recanalization seen in ~
20% within 6 ° of symptoms
12. Stroke Risk Factors Non-modifiable
AGE
Gender -male
Race – Blacks > Asians or Hispanics>
Whites
Family Hx.
Coagulation Disorders
Cardiac Disease
13. Stroke Risk Factors Modifiable
Hypertension Alcohol Abuse
Oral Contraceptives
Diabetes mellitus
Pregnancy
Hypercholesterolemia
Migraine Headaches
Elevated LDL or Low Obesity
HDL Sleep apnea
Elevated homocystein Carotid stenosis
Smoking A combination of these risk
Drug abuse factors will increase risk of
stroke!
15. THE BURDEN OF STROKE
Anually more than 15 million people world wide suffer a
stroke, 5.5 million die and 5 million are left with permanent
disability.
Stroke is 2nd most common cause of death(9.7%).
Incidence of stroke is on the increase in India and other
developing countries.
More than 80% of stroke occurs in underdeveloped and
developing countries.
Cruide annual incidence rate for first ever stroke (FES) is
145 per 100,000 Persons.
16. Case fatality rate at 28 days after FES was 29.8%.Of the
surviving patients 38.5% had moderate to severe disability.
Hypertension (BP>140/90 alone or in various combination) was
present in 82.8% cases. (dalal et al, Mumbai stroke registry,2005-
2006).
WHO estimated that in 1990 ,out of a total 9.4 million deaths in
India , 619,000 deaths were due to stroke. This gives stroke
mortality rate of 73 per 100,000 population. 1880 people die
every day in India due to stroke.
In 1990 the estimated no of death due to stroke were 22 times that
due to malaria,1.4 times that due to tuberculosis,4 times that due
to RHD, and almost equal to IHD.
Stroke mortality rate is declining in USA and other developed
countries it is likely to increase in India.
17. Stroke is a treatable condition.
IV tPA is approved for use within 3 hours ( 4.5 hours) .
(NINDS)
Intra-arterial therapy has proven to be safe and effective
within 6 hours (PROACT II)
Combined IV/IA may be more effective than IV t-PA
(Interventional Management of Stroke -IMS)
Mechanical and laser catheter technologies are showing great
promise (Angio-Jet)
18. Stroke: The Challenge
Only 1-3% of all stroke victims receive
treatment with tPA in the US .
25% of Acute MI patients receive treatment
(lytics or PTCA) in the US .
Mean time to presentation
AMI: 3hrs
Acute Stroke: 4-10hrs.
19. Reasons for lack of treatment:
1. Patient’s inability to recognize stroke symptoms
40% of stroke patients can’t name a single sign or
symptom of stroke or stroke risk factor.
75% of stroke patients misinterpret their symptoms
86% of patients believe that their symptoms aren’t
serious enough to seek urgent care
2. Physician’s lack of experience with stroke treatment and
therefore reluctance to “risk” treatment
3. Lack of organized delivery of care in many medical
centers throughout the country.
20. Current Status of Specific Treatment for Acute
Ischemic Stroke
Yes
1. Tissue plasminogen activator within 3-4.5
hrs.
2. Aspirin within 48 hrs.
3. Management in SCU
May Be
1. Neuroprotection
No ?
1. Heparin, Heparinoids
2. Hemodilution
3. Steroids
21.
22. Acute Stroke Treatments
% patients Prevention Prevention
that can death/dependency per death/dependency per
benefit 100 treated 100 admitted
Stroke Unit 90% 5 4.5
10%
Thrombolysis
ischaemic 12 1
0-3hr
strokes
65%
Aspirin
ischaemic 1 0.5
0-48hr
strokes
0.5%
Hemicraniectomy
Ischaemic 22 0.1
0-48hr
strokes
Slide by Prof G Ford, presented at UKCRN 21.11.2007 ,adapted from Gilligan et al 2005
23. Pre of hospital recognition of stoke. FAST
Facial Weakness Stroke Association campaign to
Can person smile raise awareness
Has mouth dropped Practice staff should be trained
Arm Weakness to inform doctor immediately if
Can person raise both arms patient calls with symptoms
Speech problems identifiable
Can person speak clearly and
understand what you say
Ambulance crews now trained
to use FAST score to prioritise
Test all three symptoms
Calls and dispatch.
Act FAST call 108 ambulance.
24. Section 1 Slide30
Onset to Entry (By referral method)
70
60
50
999
Pt Numbers
40
GP
Other
30 GP+999
20
10
0
0-<1 1-<2 2-<3 3-<4 4-<5 5-<6 6-<9 9-<12 12-<24 >=24
Hours
ASIST data 1999
25.
26. Pre Hospital care
Ambulance services ,health care professionals and
general public should receive education concerning
the importance of early recognition of stroke,
emphasing stroke is a medical emergency.
Stroke patients should be given a high priority by
ambulance service.
Ambulance services should be trained to identify
stroke by various tools and protocols.
Ambulance services should transfer suspected
patients to hospital with stoke unit care.
27. EMS response to 108 call:
WILL QUESTION:
Time of onset of stroke symptoms.
Determine nature of neurological symptoms (F.A.S.T.).
NIH Stroke Scale or Glasgow Coma Scale
(language/motor response/eye movement).
Hx: recent illness, surgery or trauma.
Recent use of medication/illicit drugs.
Notify receiving hospital that patient appears to be an
acute stroke and gives time window.
28. Guidelines for EMS management of patients
with suspected stroke
Recommended Not recommended
Manage ABCs Dextrose containg fluid in
Cardiac monitoring non hypoglycemic patients
Intravenous access Hypotension/excessive BP
O2(if spo2,92%) reduction
Excess IV fluids
Assess for hypoglycemia
NBM
Alert receiving ED
Rapid transfer to closest stroke
centre
29.
30.
31. Stroke units: State of the Art
Admission to a unit that is dedicated to
the care of stroke patients helps to
reduce mortality and morbidity.
42. Early diagnostic tests
ALL PATIENTS SELECTED PATIENTS
Non contrast brain CT or LFT
brain MRI Toxicology screen
Blood glucose Blood alcohol level
RFT,S. electrolytes Pregnancy test
ECG ABG
Chest radiography
Markers of cardiac ischemia
LP-if SAH is suspected and CT
CBC, Plat count*
is negative
PT,INR,*APTT*
EEG –if seizures are suspected.
O2 Saturation
43. EARLY DIAGNOSIS:
NON CONTRAST CT SCAN OF BRAIN
Initial imaging modality in hyper ac stroke
Widely available, quick, easy to perform
Accurately identifies ICH,SAH
EARLY SIGNS OF CEREBRAL ISCHAEMIA
Hyper dense MCA artery sign
Hyper dense dot sign
Hypo density of insular ribbon
Hypoensity of basal ganglia
loss of grey white matter differentiation in cortical ribbon
sulcal effacement
EARLY SIGNS ARE ASSOCIATED WITH POORER OUTCOMES
46. BRAIN IMAGING (CONTD)
MULTI MODEL CT
(A) Perfusion CT- more sensitive and specific to detect ischaemia.
(b) CT Angio-for intra and extra cranial vasculatureMULTIMODEL MRI
T1,T2,PD
DWI-Early visualization of ischaemic regions within minutes of stroke.
PWI,MRA,FLAIR,
MRI MORE SENSITIVE THAN CT(26%CT VS 83 %MRI) FOR AC
ISCHAEMIC STROKE
VASCULAR IMAGING
TCD USG,CAROTID DUPLEX SONO,CATHETER ANGIO.
47. Multimodal CT Imaging
CT PCT CTA
Tissue Status Perfusion Status Vessel Status
Bioenergetic Hemodynamic Occlusions or
Compromise Compromise Stenoses
55. Multimodal Diffusion-Perfusion MRI
DWI PWI MRA
Tissue Status Perfusion Status Vessel Status
Bioenergetic Hemodynamic Occlusions or
Compromise Compromise Stenoses
56.
57.
58. Arterial Hypertension
Management of hypertension is controversial.
Data are inconclusive,or conflicing.
Elevations of BP >160 mm of hg are detected in
>60 % patients.
Many patients have spontaneous decline in BP
during first 24 hours onset of stroke.
Both elevated and low bp are associated with poor
prognosis.
59. A reasonable goal is to lower BP by 15% during first
24 hours after onset of stroke.
It is generally agreed that antihypertensive medicines
can be restricted
24 hours after the stroke, in patients who have pre
existing hypertension and are neurologically stable.
DO NOT USE SUB LINGUAL NIFEDIPINE.IT
60. Treatment of Arterial Hypertension
(for patients who are not candidates for r TPA)
The consensus is that antihypertensive agents should be
withheld unless the diastolic blood pressure is >120
mm Hg or unless the systolic blood pressure is >220
mm Hg (level V)
61.
62.
63.
64. ARTERIAL HYPOTENSION
SBP<100 and DBP <70 is associated with higher
mobidity and mortality.
Causes of hypotension should be sought. Potential causes
are aortic dissection, volume depletion, blood loss,
decreased cardiac output sec to MI or cardiac arrhythmia.
hypovolemia should be corrected with normal saline.
65.
66. T-PA for Acute Ischemic Stroke
NEJM 95:333,1581-87
624 patients randomized
3 hour window
at three month. 30% less likely to have minimal or
no disability
6.4% risk of hemorrhage
No change in mortality at 6 mos
70. Intravenous thrombolysis
The US FDA approved the use of r tpa in 1996 on the basis of
the results of the NINDS r TPA stroke Study.
Patients treated with tpa were 30 % more likely to have minimal
or no disability at 3 months compared with placebo treated
patients.
Treatment with tpa resulted in 11 to 13 % absolute increase in
the number of patients with excellent outcomes.
Mortality rate at 3 months was 17 % in tpa group and 21 % in
placebo treated group.
Symptomatic intracerebral haemorrhage occurred in 6.4% of pts
receiving tpa vs 0.6% of the palcebo group.
71.
72. CRITERIA FOR THROMBOLYSIS WITH
rTPA
INCLUSION CRITERIA
Clinical signs and symptoms consistent with ischaenic stroke.
MEASURABLE NEUROLOGIC DEFICIT
NEUROLOGICAL SIGNS SHOULD NOT BE CLEARING
SPONTANEOUSLY.
Neurological signs should not be minor or isolated.
Onset of symptoms <3 hour before beginning treatment
Caution should be exercised in treating a patient with a major deficit.
Symptoms of stroke should not be s/o SAH.
No head trauma or prior stroke in previous 3 months.
No MI in previous 3 months.
No GI OR urinary tract haemorrhage in previous 21 days.
73. Cont..
No major surgery in previous 14 days.
No arterial puncture at a noncompressible site in previous 7 days.
NO H/O previous intra cranial haemorrhage.
Systolic BP<185 and diastolic <110
No evidence of active bleeding or ac trauma on examn
Not taking oral anticoagulant or if being taken INR <1.7
If receiving HEPARIN in previous 48 hours A PTT must be normal range.
Platelet count <1 lac mm3
Blood glucose >50 mg %
No seizure with postictal residual neurol impairements.
CT does not show a multilobar infarction (hypodensity >1/3 cerebral
hemisphere)
The patient or family understands the potential risks and benefits of
treatment.
74. New England Journal, 1995
NINDS tPA Stroke Trial
30 Hemorrhage
30
p < .05
20
20
31
9 20
20 10
10
8
0 0 1
tPA Placebo tPA Placebo
NIHSS Excellent Total Death
Recovery (%) Rate (%)
75.
76. IV administration of tpa.
Infuse 0.9mg/kg(max 90 mg ) over 60 mnts with 10 %
of the dose given as bolus over 1 mnt.
Admit pt in neuro ICU or stroke unit.
Perform neurological assessment every 15 mnts during
the infusion and every 30 mnts thereafter for next 6
hours then hourly until 24 hours after treatment.
If pt develop severe head ache,ac HTN, nausea,or
vomitting discontinue infusion and obtain emergency
CT scan.
77.
78. Besides bleeding complications r tpa have potential side effect
of angioedema that may cause partial air way obstruction.
A patient with seizure at the time of onset of stroke may be
eligible for tpa if physician is convinced that residual
impairements are secondary to stroke not a postictal
phenomenon.
IV streptokinase is not recommended .
IV ancrod, tenecteplase,reteplase,desmoteplase,urokinase
outside the setting of clinical trial is not recommended
79. Time is Brain
“The typical patient loses 1.9 million neurons each minute in which
stroke is untreated”
4.0 Upper 95% CI
favourable Outcome
3.5 Mean
3.0 Lower 95% CI
2.5
Odds Ratio
2.0
1.5
(corrected; 95% CI)
1.0
NNT: NNT: NNT: NNT:
0.5 3.5* 7* 9* 11*
(11)** (13)** (>30)**
0.0
60 90 120 150 180 210 240 270 300 330 360
Symptom-to-needle time in minutes
* NNT at absolute point of time ** NNT for each 90 min interval
Slide by Prof G Ford, presented at UKCRN 21.11.2007 based on Saver, Stroke 2006
80. Time is brain: benefit from rt-PA declines with
increasing delay from onset to treatment time
Benefit
Upper and lower 95% confidence limits
Line of no effect
Harm
IST-3 protocol 3 hours 6 hours
81. rt-PA for stroke per million pop'n Thrombolysis in Europe
60
Finland
Austria
50 Sweden
Norway
40 Belgium
Spain
Germany
30
Netherlands
Denmark
20 Italy
UK
10 Greece
France
Portugal
0
Slide donated by P. Sandercock, IST-3 trialists meeting, Brussels 2006
82. Intra arterial Thrombolysis
PROACT II
Intra arterial Prourokinase
6 Hour time window
Relative risk reduction of 15% in functional outcome
No difference in mortality
Procedural complication 9%
Early Intra cerebral haemorrhage 10%
INTRA ARTERIAL THROMBOLYS IS REASONABLE IN
PATIENTS WHO HAVE C/I TO USE OF IV TPA LIKE
RECENT SURGERY.
83. Guidelines for
Anticoagulant Therapy
Urgent administration of anticoagulants has not yet been
associated with lessening the risk of early recurrent stroke or
improving outcomes. Because it can increase the risk of brain
hemorrhage, routine use cannot be recommended.
American Heart Association, 2003
84. Guidelines for
Anticoagulant Therapy
Anticoagulants are not recommended for any subgroup
of patients with acute stroke based on any presumed
mechanism or location (e.g., cardioembolic, large
vessel atherosclerotic, vertebrobasilar, or “progressing”
stroke) because data are insufficient.
American Academy of Neurology / AHA, 2003
85. Acute Treatment with Antiplatelet Agents
Aspirin (initial dose is 325 mg) should be given within 24 to 48
hours of stroke onset in most patients (Class 1, level A).
The administration of aspirin as an adjunctive therapy, within 24
hours of the use of thrombolytic agents, is not recommended (Class
3,level A).
Aspirin should not be used as a substitute for other acute
interventions, especially intravenous administration of rtPA, for the
treatment of acute ischemic stroke (Class 3,level B).
No recommendation can be made about the urgent administration of
other antiplatelet aggregating agents alone or in combination with
aspirin (Class 3,level C).
Outside the setting of clinical trials IV administration of antiplatelet
agents that inhibit the glycoprotein 2b/3a ptor is not recommended.
(Class 3,level B).
86. Benefit of Early Aspirin Treatment in Acute
Ischemic Stroke
9 patients benefit per 1000 treated (p<0.001)
2000 Aspirin, n=20,207 Control, n=20,190
1843
1662
1500 1327
1231
1000
636
496
500
205 168
0
Recurrent Hemorrhagic Death Death or Nonfatal
Ischemic Stroke Stroke Stroke
Combined Data from IST, CAST, MAST-I
87. Hemodilution,Vasodialators,and
induced hypertension
Hemodilution with or without venesection and volume
expansion is not recommended for treatment of ac
ischaemic stroke.(Class 3,level A)
Vasodialators like pentoxifyline is not recommended
for treatment of ac stroke.(Class 3 ,level A)
Drug induced hypertension outside the setting of
clinical trials is not recommended .)
89. MERCI RESULTS
Recanalization in 46%
Historical 18%
Complication rate 7% (SAH, device fx,
embolization)
With recanalization, good outcome (46% vs.
10%) and mortality improved (32% vs. 54%)
ICH rate 7.8%
90.
91. Thrombolysis Augmentation
Ultrasound
With or without micro-bubbles
Micro-bubbles containing TPA
Combination with G2B3A inhibitors
92. Neuroprotective agents
At present no neuroprotective agent is found to
be effective in improving outcomes after
stroke,and therefore none currently can be
recommended(class 3,level A)
93. General Ac treatment after Hospitalization
25 %of patients may have neurological worsening during first
24-48 hours.
The use of stroke unit is recommended to improve general
management.
Early mobilization of less severely affected patients is
recommended.
Assessment of swallowing before staring eating or drinking is
recommended.
Patients with suspected pneumonia,UTI should be treated
with antibiotics.
94. Sub cut anticoagulants are recommended for treatment of
immobilized patients to prevent DVT.Ideal timing for
starting these medications is not known.
The use of intermittent external compression devices is
recommended for treatment of patients who can not
receive antcoagulants.(Class 2a ,level B)
Pulmonary embolism accounts for 10% of deaths after
stroke,and complicaton may be detected in 1%of patients
who have had a stroke.
95. Patients who cannot take food and fluids orally should
receive nasogastric,nasodudenal or PEG feedings to
maintain hydration and nutrition.The timing of PEG is
uncertain.
Nutritional supplements are not needed.
Prophylactic administration antibiotic is not
recommended.
If possible the placement of indwelling bladder
catheters should be avoided because of associated risk
of UTI.(class3 ,level C)
96. Treatment of ac neurological Complications
Brain Edema
Development of brain edema is gradual and occurs most frequently
3- 5 days after stroke.
Brain edema is most frequent neurological cause of death in
patients with stroke.
Early CTscan hypodensity,defined as <12 hours after onset ,of >50
%of the MCA territory and presence of hyperdense MCA signs
are independent predictors of neurological deterioration.
Large hypodensity>2/3 of MCA terrority on CT and large
hypoperfusion on CT perfusion maps predicted development of
malignant MCA infarct.
97. Management of brain edema and increased ICP
Modest fluid restriction
Avoidence of hypo osmolar fluids like GDW.
Control of fever,hypoxia,hypercapnia.
Elevation of head end of bed by 30 degree.
Hyperventilation to a partial co2 pressure of 28-
30 mm of hg.
98. Administration of mannitol 0.25-0.50gm /kg IV
over 30 mnts every 6 hours.
Diuresis(furosemide 40 mg IV).
Drainage of CSF.
Resection of infarcted tissue./decompressive
surgery.
Antihypertensive agents particularly those
causing cerebral vasodilation should be avoided.
99. Contd……
Patients with ac hydrocephalus in ischaemic stroke most commonly
affecting cerebellum can be treated with placement of a ventricular
drain.(class 1 level B)
Decompressive craniectomy is indicated for treatment of large
cerebellar infarcts in patients with clinical deterioration and
evidence of early brain stem compression or hydrocephalus.This is
potentially life saving measure and clinical recovery may be very
good.(class 1 ,level B)
Decompressive surgery for malignant brain edema may be life
saving in selected patients with complete MCA infarction who are
significant risk for developing trans tentorial herniation.Timing of
surgery is poorly defined,with some opting for early surgery (in 24
hours)
Suboccipital craniotomy is the treatment to relieve both
hydrocephalus and brain stem compression caused by large
cerebellar infarctions.
100. No specific recommendation is made for treatment of
patients with asymptomatic haemorrhagic
transformation after ischaemic stroke.
Corticosteroids are not recommended for treatment of
cerebral edema and increased ICP(class 3,level A)
Prophylactic administration of anticonvulsants in
patients of stroke who have not had seizures is not
recommended(class 3 ,level C)
Sudden: Sudden onset out of full health DD post MI, endocarditis, vasculitis, mets Focal: intoxication, vasculitis, encephalitis, hysteria, >24 hrs: TIA, Todd’s, migraine Presumed non-traumatic vascular origin: exclude head trauma, neck trauma, whiplash, systemic vascultitis, cardiac source of emboli AF, but also endocarditis, post MI, hypotension
Each year, 40,000 more women than men have strokes. Stroke or heart disease in parents younger than 60 years of age. Cardiac Disease – A fib, CHF, Cardiomyopathy, Valve disease, Cardiac procedures CCL
Homocysteine is an amino acid in the blood. Too much of it is related to a higher risk of coronary heart disease, stroke and peripheral vascular disease (fatty deposits in peripheral arteries). Evidence suggests that homocysteine may promote atherosclerosis (fatty deposits in blood vessels) by damaging the inner lining of arteries and promoting blood clots. However, a causal link hasn't been established. Folic acid and other B vitamins help break down homocysteine in the body.
ER Procedure: Differential Diagnosis In stroke patients, clinical features are usually sufficient to enable at least preliminary diagnosis. CT scanning is instrumental in documenting cerebral haemorrhage, neuroinfection or brain injury, but does not help to exclude possibilities such as syncope, partial epileptic seizure with Todd’s paresis, migraine attack with aura, hypoglycaemia, hysteria, intoxication, meningitis or multiple sclerosis. In this context, it is important to remain aware that confirmatory tests should supplement – rather than replace – conventional clinical skills. In practice, the most important distinction is between ischaemic stroke and intracranial haemorrhage. The clinical features of these conditions may overlap, but their treatment is markedly different. 1 Early distinction between the various subtypes of ischaemic stroke is also becoming important (i.e. lacunar vs large artery or cardioembolic stroke), as there is evidence that these may respond differently to different treatments. This is a situation in which neuroimaging techniques such as CT scanning can be invaluable, although clinical scoring systems based on the presence or absence of specific clinical features can also be strongly predictive. One such system – the Allen score – has been found to be 90% accurate in the identification of haemorrhage. 2–4 References 1. European Ad Hoc Consensus Group. European strategies for early intervention in stroke: a report of an Ad Hoc Consensus Group meeting. Cerebrovasc Dis 1996; 6: 315–24. 2. Allen CMC. Clinical diagnosis of the acute stroke syndrome. Q J Med 1984; 208: 515–23. 3. Sandercock PAG, Allen CMC, Corston RN et al. Clinical diagnosis of intracranial haemorrhage using Guy’s hospital score. Br Med J 1985; 291: 1675–7. 4. Celani MG, Righetti E, Migliacci R et al. Comparability and validity of two clinical scores in the early differential diagnosis of acute stroke. Br Med J 1994 ; 308: 1674–6 27
Aspirin should be given within 24 to 48 hours of stroke onset in most patients (grade A )