Acute appendicitis is caused by obstruction of the narrow appendix, which becomes thrombosed due to its end artery blood supply. The appendix's submucosal lymphoid tissue hypertrophies with inflammation behind the obstruction, causing severe pain. Clinical presentation varies from localized right lower quadrant pain to atypical in different positions or extremes of age. Investigations include blood tests, ultrasound, and sometimes CT or laparoscopy. Treatment involves resuscitation, nil by mouth, antibiotics, and appendectomy surgery using various incisions or laparoscopically. Complications include wound infections, abscesses, ileus, and fistulas.