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Understanding Achalasia of
the Cardia
BY
PROF. KHALED MAHRAN
MINIA UNIVERSITY
Definition
 Achalasia of the Cardia is a rare esophageal motility disorder
characterized by the inability of the lower esophageal sphincter (LES) to
relax during swallowing, as well as impaired peristalsis of the
esophageal body.
 - The LES fails to open properly, causing food and liquids to
accumulate in the esophagus, leading to dysphagia (difficulty
swallowing), regurgitation, chest pain, and other discomforting
symptoms.
Symptoms
 Achalasia typically affects adults between 30 and 50 years of age, with a
peak in the 40s.
 The disorder is about twice as common in men than women (or equal).
 - Patients with Achalasia may experience a variety of symptoms, including:
 - Dysphagia (difficulty swallowing), especially with solids and liquids.
 - Regurgitation of undigested food or liquid, often accompanied by a sour taste.
 - Chest pain or discomfort, which may worsen after eating.
 - Weight loss due to difficulty in consuming adequate nutrients.
 - Heartburn, despite the presence of a LES malfunction.
Diagnosis
 - Diagnosis of Achalasia typically involves a combination of clinical assessment
and diagnostic tests, including:
 - Barium swallow study: A fluoroscopic examination where the patient
swallows a barium solution, allowing visualization of esophageal abnormalities.
 - Esophageal manometry: Measures pressure and motility of the
esophagus, helping to identify abnormalities in LES relaxation and peristalsis.
 - Endoscopy: Used to rule out other esophageal disorders and evaluate the
condition of the esophageal mucosa.
Esophageal carcinoma
Endoscopic view of achalasia
Treatment Options
 - Although Achalasia is a chronic condition with no cure, several treatment
options can help alleviate symptoms and improve the quality of life for patients:
 - Medications : GTN, Calcium channel blockers
 - Pneumatic dilation: A procedure where a balloon is inserted into the LES and
inflated to stretch the muscles and improve swallowing function.
 - Surgical myotomy: Laparoscopic Heller myotomy involves cutting the muscles
of the LES to allow easier passage of food into the stomach (laparoscopic, POEM).
 - Botulinum toxin injection: Temporary relief can be achieved by injecting
botulinum toxin into the LES, which paralyzes the muscles and facilitates relaxation.
Complications
 - If left untreated, Achalasia can lead to various complications, including:
 - Esophageal dilation and megaesophagus: Chronic obstruction can cause the esophagus
to dilate and lose its ability to contract effectively.
- Esophageal tears or perforations: Increased pressure within the esophagus may
result in tears or perforations, leading to serious infections and other life-threatening
complications.
- Increased risk of aspiration pneumonia: Food and liquid regurgitation can lead to
aspiration, increasing the risk of pneumonia.
Malignancy (0.4% to 9.2%) : eosphageal adenocarcinoima and squamous
cell carcinoma
Conclusion
 - In conclusion, Achalasia of the Cardia is a complex esophageal disorder
characterized by impaired LES relaxation and esophageal motility.
 - Early diagnosis and appropriate management are crucial in preventing
complications and improving the quality of life for patients living with
Achalasia.
 - Thank you for your attention. Now, I'm open to any questions or
discussions you may have.

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achalasia of cardia.pptxmmmmmmmmmmmmmmmm

  • 1. Understanding Achalasia of the Cardia BY PROF. KHALED MAHRAN MINIA UNIVERSITY
  • 2. Definition  Achalasia of the Cardia is a rare esophageal motility disorder characterized by the inability of the lower esophageal sphincter (LES) to relax during swallowing, as well as impaired peristalsis of the esophageal body.  - The LES fails to open properly, causing food and liquids to accumulate in the esophagus, leading to dysphagia (difficulty swallowing), regurgitation, chest pain, and other discomforting symptoms.
  • 3. Symptoms  Achalasia typically affects adults between 30 and 50 years of age, with a peak in the 40s.  The disorder is about twice as common in men than women (or equal).  - Patients with Achalasia may experience a variety of symptoms, including:  - Dysphagia (difficulty swallowing), especially with solids and liquids.  - Regurgitation of undigested food or liquid, often accompanied by a sour taste.  - Chest pain or discomfort, which may worsen after eating.  - Weight loss due to difficulty in consuming adequate nutrients.  - Heartburn, despite the presence of a LES malfunction.
  • 4. Diagnosis  - Diagnosis of Achalasia typically involves a combination of clinical assessment and diagnostic tests, including:  - Barium swallow study: A fluoroscopic examination where the patient swallows a barium solution, allowing visualization of esophageal abnormalities.  - Esophageal manometry: Measures pressure and motility of the esophagus, helping to identify abnormalities in LES relaxation and peristalsis.  - Endoscopy: Used to rule out other esophageal disorders and evaluate the condition of the esophageal mucosa.
  • 5.
  • 7. Endoscopic view of achalasia
  • 8. Treatment Options  - Although Achalasia is a chronic condition with no cure, several treatment options can help alleviate symptoms and improve the quality of life for patients:  - Medications : GTN, Calcium channel blockers  - Pneumatic dilation: A procedure where a balloon is inserted into the LES and inflated to stretch the muscles and improve swallowing function.  - Surgical myotomy: Laparoscopic Heller myotomy involves cutting the muscles of the LES to allow easier passage of food into the stomach (laparoscopic, POEM).  - Botulinum toxin injection: Temporary relief can be achieved by injecting botulinum toxin into the LES, which paralyzes the muscles and facilitates relaxation.
  • 9. Complications  - If left untreated, Achalasia can lead to various complications, including:  - Esophageal dilation and megaesophagus: Chronic obstruction can cause the esophagus to dilate and lose its ability to contract effectively. - Esophageal tears or perforations: Increased pressure within the esophagus may result in tears or perforations, leading to serious infections and other life-threatening complications. - Increased risk of aspiration pneumonia: Food and liquid regurgitation can lead to aspiration, increasing the risk of pneumonia. Malignancy (0.4% to 9.2%) : eosphageal adenocarcinoima and squamous cell carcinoma
  • 10. Conclusion  - In conclusion, Achalasia of the Cardia is a complex esophageal disorder characterized by impaired LES relaxation and esophageal motility.  - Early diagnosis and appropriate management are crucial in preventing complications and improving the quality of life for patients living with Achalasia.  - Thank you for your attention. Now, I'm open to any questions or discussions you may have.