Disorders of the placenta including: FGR, pre-eclampsia, placental abruption and abnormal (velamentous) cord insertion are associated with over 50% of stillbirths and are frequently cited as the primary cause of death [1–3]. Abnormal placental structure and function significantly increases the risk of stillbirth.
Placenta accreta, placenta increta, and placenta percreta. Abnormal placental implantation (accreta, incretak, and percreta) is described using a general clinical term, respectively, morbidly adherent placenta (MAP) [2] or “abnormal invasive placenta” (AIP).
Disorders of the placenta including: FGR, pre-eclampsia, placental abruption and abnormal (velamentous) cord insertion are associated with over 50% of stillbirths and are frequently cited as the primary cause of death [1–3]. Abnormal placental structure and function significantly increases the risk of stillbirth.
Placenta accreta, placenta increta, and placenta percreta. Abnormal placental implantation (accreta, incretak, and percreta) is described using a general clinical term, respectively, morbidly adherent placenta (MAP) [2] or “abnormal invasive placenta” (AIP).
This topic contains definition, incidence, varieties, causes, risk factors, dangers, diagnosis, prognosis, prevention and management of inversion of uterus.
This topic contains definition, incidence, types, causes, diagnosis, mechanism, management of occipito posterior position and deep transverse arrest and manual rotation of occipito posterior position
In ectopic pregnancy, implantation occupies at a site other than the endometrium. Ectopic pregnancies are responsible for approximately 10 percent of all maternal mortality. The prognosis for future reproduction is poor. Only one half of women having an ectopic pregnancy are eventually delivered of a liveborn infant. Various factors contribute to ectopic pregnancies, the most common being infection. Unlike intrauterine spontaneous abortions, genetic factors are not paramount in the etiology of ectopic pregnancy.
“Difficulty encountered in the delivery of the fetal shoulders after delivery of the head.”
Shoulder dystocia is an unpredictable obstetric complication with the incidence of 0.15% to 2%.
An increase in the incidence of shoulder dystocia has been recorded over the last 20 years. Incidence appears to be increasing as birth weights increase.
This topic contains definition, incidence, varieties, causes, risk factors, dangers, diagnosis, prognosis, prevention and management of inversion of uterus.
This topic contains definition, incidence, types, causes, diagnosis, mechanism, management of occipito posterior position and deep transverse arrest and manual rotation of occipito posterior position
In ectopic pregnancy, implantation occupies at a site other than the endometrium. Ectopic pregnancies are responsible for approximately 10 percent of all maternal mortality. The prognosis for future reproduction is poor. Only one half of women having an ectopic pregnancy are eventually delivered of a liveborn infant. Various factors contribute to ectopic pregnancies, the most common being infection. Unlike intrauterine spontaneous abortions, genetic factors are not paramount in the etiology of ectopic pregnancy.
“Difficulty encountered in the delivery of the fetal shoulders after delivery of the head.”
Shoulder dystocia is an unpredictable obstetric complication with the incidence of 0.15% to 2%.
An increase in the incidence of shoulder dystocia has been recorded over the last 20 years. Incidence appears to be increasing as birth weights increase.
The placenta is partly maternal and party fetal in origin. It is the connecting link between mother and fetus. The survival of the fetus depends on the integrity and efficiency of placenta.
Placenta if developed from Chorionic Frondosum and deciduas.
It begins at 6 wk and completed by 12th wk.
Soemetimes, there is marked variation in the morphology including size, shape and weight of the placenta.
some of the common abnormalities are-
large placenta, small placenta, placenta marginata, placenta succenturaita
pleacenta extrachorialis
placenta membranecea, battledore placenta, bipartite tripartite placenta
Abnormalities of the placenta are important to recognize owing to the potential for maternal and fetal morbidity and mortality. Pathologic conditions of the placenta include
Placental causes of hemorrhage,
Gestational trophoblastic disease,
Retained products of conception,
Nontrophoblastic placental tumors, metastases, and
Cystic lesions..
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. What is Placenta?
It is an organ which is responsible for nourishing and
protecting a fetus during pregnancy
Placental abnormalities-
it refers to marked variations including anatomical,
physiological and abnormal implantations of
placenta that may lead to serious placental maternal
fetal effects
4. Functions of placenta
Respiratory
Excretory
Nutritive
Endocrine functions
Barrier function
Immunological function
5. Abnormalities of placenta
Classified according to
Size and shape
Placental implantation
Circulatory disturbances
Placental tumors
8. Placenta succenturiate
one or more small lobes of placenta, size of cotyledon may be
placed at varying distances from the placental margin
Incidence- 3%
Clinical significance-
If the succenturiate lobe is retained following delivery of
placenta it may lead to
PPH
Subinvolution
Uterine sepsis
Polyp formation
9. Placenta Spuria-
Placenta succenturiate in which
there is absence of communicating
blood vessels it is called placenta
spuria
11. Circumvallate placenta
The fetal surface is divided into a
central depressed zone surrounded by
a thickened white ring which is usually
complete.
Vessels radiate from the cord
insertion as far as the ring and
then disappear from view.
The peripheral zone outside the ring
is thicker and the edge is elevated
and rounded.
Incidence- 0.5-18%
12. Placenta Marginata
A thin fibrous ring is present at
the margin of the chorionic
plate where the fetal vessels
appear to terminate.
13. Clinical significance
There are increased chance of
Antepartum hemorrhage
FGR baby
Abortion
Preterm delivery
Retained placenta or membranes
14. Placenta Membranecea
Placenta is unduly large and thin
The placenta not only develops
from the chorion frondosum but
also from the chorion laeve so
that the whole of the ovum is
practically covered by the
placenta
15.
16. Clinical significance
Encroachment of some part over the lower
segment.
Imperfect separation in the third stage.
Chance of retained placenta is more and
manual removal becomes difficult.
17. Placenta bilobate/Bipartite
Placenta may develop as separate and
nearly equally sized discs
Umbilical cord is attached into a
connecting chorionic bridge or
intervening membranes
Clinical significance
Same as placenta Succenturiate
18. Placenta Fenestrata
This is due to missing of
central portion of the
placental disk
Clinical Significance
It may be mistaken as if the
central cotyledon is retained
inside uterus
20. Placenta accrete Syndromes
These are abnormally implanted
invasive or adhered placenta
Placenta accreta - indicates villi are
attached in myometrium
Placenta increta - indicates villi
actually invade the myometrium
Placenta percreta- villi that
penetrate through the myometrium
and to or through serosa
21. Clinical significance
They are leading cause of intractable postpartum
haemorrhage and emergency peripartum
hysterectomy
23. Abnormalities R/T circulation
A. Subchorionic fibrin deposition- These are caused
by slowing of maternal blood flow within the
intervillus space
B. Perivillous fibrin deposition-maternal flow stasis
around an individual villus results in perivillous
fibrin deposition
C. Maternal floor infarction
D. Intervillous thrombus
E. Infarction
24. Clinical significance
These are common lesions in mature placentas and
are benign in limited numbers
If they are numerous placental insufficiency can
develop
27. Placental calcification
Calcium salts may be deposited throughout the placenta, but
are most common on basal plate
Calcification arises within advancing gestation and is
associated with nullipariy, smoking, Increase in maternal
serum calcium levels
31. Abnormalities of Umbilical Cord
Short cord - Less than 20cm or commonly relative
due to entanglement of the cord round any fetal part.
In exceptional circumstances, the cord may be absent and
the placenta may be attached to the liver as in
exomphalus.(acordia)
32.
33. Clinical significance
Prevent descent of the presenting part specially during labour
Separation of normally situated placenta
Favour malpresentation
Acute inversion
Fetal growth restriction
Intrapartum distress
Failure of external version
Two fold risk of fetal death
34. Long cord -
If length is more than 100cm
Clinical significance
cord prolapse
cord entanglement round the neck or the body
True knot False knots
35.
36. Single umbilical artery
It is more common in twins and in babies born of
diabetic mothers or in polyhydramnios
37. Clinical significance
It is frequently associated with congenital
malformation of the fetus (10-20%).
Renal and genital anomalies, Trisomy 18 are
common.
There is increased chance of
Abortion, Prematurity, FGR
Perinatal mortality
38. Cord insertion
Battledore placenta-
The cord is attachedto the margin of the
placenta.
If associated with low implantation of the
placenta, there is chance of cord compression in
vaginal delivery leading to fetal anoxia or even
death; otherwise, it has got little clinical
significance.
40. Velamentous placenta
The umbilical vessels spread within the
membranes at a distance from the placental
margin, which they reach surrounded only by a fold
of amnion.
Although their incidence is approximately 1
percent, velamentous insertion develops in
more commonly with placenta previa and
multifetal gestations.
41.
42. Vasa previa
If the leash of blood vessels happen to
traverse through the membranes overlying the
internal os, infront of the presenting part, the
condition is called vasa praevia.
44. False Knots
False knots appear as knobs protruding from the cord surface and are
focal redundancies of a vessel or Wharton jelly, with no clinical significance.
45. True knots
Active fetal movements create cord knotting.
Incidence : approximately 1%, and these are
more common in monoamnionic twins.
The risk of stillbirth is increased five- to
tenfold.
46. Loops
The cord frequentlybecomes coiled around portions of the
fetus.
Those looped around theneck aretermed a nuchal
cord
several large studies have reported one loop of nuchal
cord in 20 to 34 percent of deliveries; two loops in 2.5
to 5 percent; and three loops in 0.2 to 0.5 percent
48. Clinical significance
As labor progresses, contractions may
compress the cord vessels and create fetal
heart rate decelerations that persist until
the contraction ceases.
50. Umbilical stricture
This is a focal narrowing of the cord diameter that typically
develops in the area of fetal umbilical insertion .
Absence of Wharton Jelly and stenosis or obliteration of cord
vessels at the narrow segment are characteristic pathological
feature
Most foetuses are stillborn
52. Hematomas
Associated with short cords,trauma and entanglement
Results from varix rupture usually of the umbilical vein
May also be caused by umbilical vessel venipuncture
54. Cysts
True cysts are epithelium-lined remnants of
the allantois and may co-exist with a persistently
patent urachus.
In contrast,the more common pseudocysts
form from local degeneration of Wharton jelly.
55. Clinical significance
Single umbilical cord cysts found in the first
trimester tend to resolve completely, whereas
multiple cysts may portend miscarriage or
aneuploidy.
Moreover, pseudocysts persisting beyond this can
be associated with structural and
chromosomal anomalies defects, especially
trisomy 18 and 13.
64. Q.2-Umbilical cord comprises how many arteries &
veins?
a) 2 arteries & 2 veins
b) 2 arteries & 1 vein
c) 1 artery & 2 veins
d) 1 artery & 1 vein
65. Q.3 what is clinical significance of battledore
placenta?
Postpartum haemorrhage
Cord compression
Retained placenta
None of the above
66. Q.4 what is chorioamnionitis?
Abnormality of chorion
Abnormality of placental membranes
Inflammation of placental membranes
Inflammation of placenta
Editor's Notes
A leash of vessels connecting the main to the small lobe traverse through the membranes.the accessory lobe is developed from the activated villi on the chorionic laeve
Treatment –whenever the diagnosis of missing lobe is made,exploration of the uterus and removal of the lobe under general anesthesia is to be done
Placenta extrachorialis is a morphological abnormality of the placenta, defined as "a condition in which the transition from a membranous to villous chorion does not occur at the placental edge but at some variable distance within the circumference of the placenta" (1).
Therefore there is placental tissue beyond the limits of the chorionic plate. The basal plate of villous tissue (located on the maternal side of the placenta) extends laterally beyond the chorionic plate from which the villi originate (located on the fetal side).
The chorionic plate is thus smaller than the basal plate (1). This arrangement leaves some placental tissue outside the limits of the chorionic plate, hence the name placenta extrachorialis
The placenta of such type is due to the smaller chorionic plate than the basal plate
The chorionic plate does not extend to the placental margin.
Increased risk of vaginal bleeding at the beginning of first trimester,risk of PPROM,preterm deliveries,placental insufficiency,placental abruption
If it is found antenatally ..this pregnancy is classified as high risk pregnancy
These abnormalities are serious variations in which trophoblastic tissues invade the myometrium to varying depths.
Mal adherent placenta