The 5th International Conference on e-Learning (ICEL) was held on July 12-13, 2010 in Penang, Malaysia. The conference program consisted of keynote addresses, paper presentations split into four concurrent streams (A-D) each day, and poster sessions. Presentation topics included e-learning strategies, blended learning, mobile learning, perceptions of e-learning, applications of e-learning, assessment, and case studies. Keynote speakers addressed using mobile devices to promote student-centered learning and the impact of digital natives in higher education. Over 100 presentations were given over the two day period covering various aspects of e-learning research and practice.