The document discusses epidemiological data on chronic total occlusions (CTOs). It finds that CTO prevalence can range from 20-40% of patients with documented coronary artery disease to 10% of percutaneous coronary intervention targets. A 2005 study found CTOs in 24% of patients and 52% of those with significant stenosis. National differences in CTO prevalence may be due to genetic, dietary, smoking, and access to care factors. It concludes that knowing a region's prevalence of these risk factors can help modify approaches.