This document discusses risk stratification strategies for sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). It outlines several established risk factors for SCD in HCM including family history of SCD, increased left ventricular wall thickness, unexplained syncope, non-sustained ventricular tachycardia, left ventricular outflow tract obstruction, abnormal blood pressure response to exercise, and late gadolinium enhancement on cardiac MRI. The document also discusses newer risk markers such as left atrial size, atrial fibrillation, systolic dysfunction, and the potential impact of septal reduction therapies on reducing SCD risk in patients with HCM.
Clinical Profile of Acute Coronary Syndrome among Young AdultsPremier Publishers
Acute Coronary Syndrome accounts for 30% of hospital admissions with cardiovascular diseases. The risk of this syndrome is increasing among the younger adults, and a deep insight into the clinical profile among these patients will help in devising a preventive strategy, in order to alleviate the morbidity and mortality due to the syndrome. A cross sectional study was done among 125 subjects admitted to our tertiary care hospital with Acute Coronary Syndrome. Their risk factors were assessed and a 12 Lead electrocardiogram and 2D Echocardiogram were taken. Cardio III panel which consists of Troponin I, CK MB, BNP by COBAS meter machine was also measured. STEMI was present in 73.6% of the patients, while unstable angina was present in 16%. About 90% of STEMI patients were males and 62% of them were hypertensives. LV Ejection Fraction <30% was found in 9% of STEMI patients. This study elucidates the need for a preventive strategy for primordial prevention of cardiovascular events among young adults. The study envisaged the male, urban preponderance towards these events.
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical Prostatectomy
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the
predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical
Prostatectomy
Clinical Profile of Acute Coronary Syndrome among Young AdultsPremier Publishers
Acute Coronary Syndrome accounts for 30% of hospital admissions with cardiovascular diseases. The risk of this syndrome is increasing among the younger adults, and a deep insight into the clinical profile among these patients will help in devising a preventive strategy, in order to alleviate the morbidity and mortality due to the syndrome. A cross sectional study was done among 125 subjects admitted to our tertiary care hospital with Acute Coronary Syndrome. Their risk factors were assessed and a 12 Lead electrocardiogram and 2D Echocardiogram were taken. Cardio III panel which consists of Troponin I, CK MB, BNP by COBAS meter machine was also measured. STEMI was present in 73.6% of the patients, while unstable angina was present in 16%. About 90% of STEMI patients were males and 62% of them were hypertensives. LV Ejection Fraction <30% was found in 9% of STEMI patients. This study elucidates the need for a preventive strategy for primordial prevention of cardiovascular events among young adults. The study envisaged the male, urban preponderance towards these events.
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical Prostatectomy
The Impact of Lymph Node Dissection on Survival in Intermediate- and High-Ris...semualkaira
Aimed to evaluate the therapeutic effect of pelvic lymph node dissection (PLND) on survival and determine the
predictors of lymph node involvement (LNI) in patients with intermediate- or high-risk prostate cancer (PCa) treated with Radical
Prostatectomy
Comorbidities and Other Predictors for Severity of Colonic Diverticulitis?semualkaira
Predicting severity of acute colonic diverticulitis (ACD) is important for management, morbidity and mortality. The aim of this study is evaluating the Charlson’s Comorbidity Index (CCI) as severity predictor of ACD.
Cardiovascular risk evaluation and management before renal transplantation sl...Christos Argyropoulos
Presentation focused on pre-operative evaluation of Major Adverse Cardiac Events prior to renal transplantation.
Modified from a presentation I gave in 2007; compared to the original there is a less enthusiastic endorsement of a peri-operative fixed dose beta blockade administration strategy given the discrepant results of the POISE and DECREASE-II studies
CVST central venous sinus thrombosis.pptxajitjagtap13
Ppt covers extensively about CEREBRAL VENOUS SINUS THROMBOSIS.
Topics of scope include
Introduction
Epidemiology
Risk factors
Clinical features
Diagnosis
And treatment of cvt.
Author is medicine resident at LTMGH, SION Mumbai.
Coronary heart disease is best addressed by a comprehensive approach aimed at halting atherosclerotic disease and reducing the risk of thrombosis. Unfortunately, our success in optimal risk factor modification in patients with stable CHD remains poor: only 41% of patients achieved all basic goals in the recent ISCHEMIA trial, with success rates likely even lower outside the rigorous clinical trial context. A greater focus on achieving prevention goals in patients with CHD will have a substantial impact on patient outcome and rates of hospitalization and more resources and incentives should be allocated for improved secondary prevention.
The ISCHEMIA trial suggests that even selected, high-risk patients with extensive ischemic burden do not benefit from revascularization barring unacceptable angina despite OMT. As ISCHEMIA excluded patients with unacceptable angina, advanced heart failure, and those with unprotected left main disease, our evaluation may be geared to identify such patients for consideration of revascularization alongside an initial strategy of OMT.
Atherosclerosis is a systemic disease of the arterial circulation, with focal areas of more severe manifestation. From an imaging standpoint, the paradigm of ischemia testing may have come to an end. Recent evidence from COURAGE, PROMISE, SCOT-HEART, and ISCHEMIA has demonstrated that functional testing for inducible myocardial ischemia is inferior to anatomic assessment for risk stratifying and managing patients with suspected or known CHD. Consistent with a large body of evidence, risk from CHD is mediated by the extent of atherosclerotic disease burden and not by the extent of inducible ischemia. Given that 55% of patients had nonobstructive CHD by CT in PROMISE, which was associated with 77% of cardiovascular deaths and myocardial infarctions at follow-up, there is immense opportunity to impact the disease at an earlier stage in a very large population of patients with occult CHD.
CT coronary angiography in ED chest pain patientskellyam18
CT coronary angiography is the new kid on the block for assessing emergency department patients with chest pain. How accurate is it? What are the down sides? How useful is it? Which patients is it suitable for? This presentation attempts to answer these questions in light of current evidence.
The first Mexican multicenter register on ischaemic stroke (The PREMIER Study...Erwin Chiquete, MD, PhD
The readers of the International Journal
of Stroke may be interested to know that
in Mexico, information on acute care
and long-term outcome of patients
with ischaemic stroke (IS) and transient
ischaemic attack (TIA) is still unknown.
TheMexicanPREMIERregistry, amulticentre
first-step stroke surveillance system,
was designed to investigate on risk
factors, acute care, secondary prevention
strategies and long-term outcome of
patients with IS and TIA. Here, we
present information on acute care and
one-year outcome of the IS cohort.
Comorbidities and Other Predictors for Severity of Colonic Diverticulitis?semualkaira
Predicting severity of acute colonic diverticulitis (ACD) is important for management, morbidity and mortality. The aim of this study is evaluating the Charlson’s Comorbidity Index (CCI) as severity predictor of ACD.
Cardiovascular risk evaluation and management before renal transplantation sl...Christos Argyropoulos
Presentation focused on pre-operative evaluation of Major Adverse Cardiac Events prior to renal transplantation.
Modified from a presentation I gave in 2007; compared to the original there is a less enthusiastic endorsement of a peri-operative fixed dose beta blockade administration strategy given the discrepant results of the POISE and DECREASE-II studies
CVST central venous sinus thrombosis.pptxajitjagtap13
Ppt covers extensively about CEREBRAL VENOUS SINUS THROMBOSIS.
Topics of scope include
Introduction
Epidemiology
Risk factors
Clinical features
Diagnosis
And treatment of cvt.
Author is medicine resident at LTMGH, SION Mumbai.
Coronary heart disease is best addressed by a comprehensive approach aimed at halting atherosclerotic disease and reducing the risk of thrombosis. Unfortunately, our success in optimal risk factor modification in patients with stable CHD remains poor: only 41% of patients achieved all basic goals in the recent ISCHEMIA trial, with success rates likely even lower outside the rigorous clinical trial context. A greater focus on achieving prevention goals in patients with CHD will have a substantial impact on patient outcome and rates of hospitalization and more resources and incentives should be allocated for improved secondary prevention.
The ISCHEMIA trial suggests that even selected, high-risk patients with extensive ischemic burden do not benefit from revascularization barring unacceptable angina despite OMT. As ISCHEMIA excluded patients with unacceptable angina, advanced heart failure, and those with unprotected left main disease, our evaluation may be geared to identify such patients for consideration of revascularization alongside an initial strategy of OMT.
Atherosclerosis is a systemic disease of the arterial circulation, with focal areas of more severe manifestation. From an imaging standpoint, the paradigm of ischemia testing may have come to an end. Recent evidence from COURAGE, PROMISE, SCOT-HEART, and ISCHEMIA has demonstrated that functional testing for inducible myocardial ischemia is inferior to anatomic assessment for risk stratifying and managing patients with suspected or known CHD. Consistent with a large body of evidence, risk from CHD is mediated by the extent of atherosclerotic disease burden and not by the extent of inducible ischemia. Given that 55% of patients had nonobstructive CHD by CT in PROMISE, which was associated with 77% of cardiovascular deaths and myocardial infarctions at follow-up, there is immense opportunity to impact the disease at an earlier stage in a very large population of patients with occult CHD.
CT coronary angiography in ED chest pain patientskellyam18
CT coronary angiography is the new kid on the block for assessing emergency department patients with chest pain. How accurate is it? What are the down sides? How useful is it? Which patients is it suitable for? This presentation attempts to answer these questions in light of current evidence.
The first Mexican multicenter register on ischaemic stroke (The PREMIER Study...Erwin Chiquete, MD, PhD
The readers of the International Journal
of Stroke may be interested to know that
in Mexico, information on acute care
and long-term outcome of patients
with ischaemic stroke (IS) and transient
ischaemic attack (TIA) is still unknown.
TheMexicanPREMIERregistry, amulticentre
first-step stroke surveillance system,
was designed to investigate on risk
factors, acute care, secondary prevention
strategies and long-term outcome of
patients with IS and TIA. Here, we
present information on acute care and
one-year outcome of the IS cohort.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Layout
• Incidence of SCD
• Mechanisms of SCD
• Risk factors for SCD
• Evolution of Risk Stratification strategies
3. Sudden Cardiac
Death
Responsible for ~ 50%
of all CV deaths
As per the Resuscitation
Outcomes Consortium
(ROC) registry of
OOHCA from 2005 to
2015; the incidence of all
EMS-assessed cardiac
arrests was 110.8 per
100,000.
Wong C et al. Epidemiology of SCD. Heart Lung Circ 2019.
4. SCD - HCM
The prevention of SCD represents the most complicated challenge with respect to HCM.
◦ SCD is the most common cause of death in HCM and often affects young and frequently asymptomatic
patients. (1)
◦ The annual SCD rate is <1%, but there are subgroups with much higher incidence.
◦ Most common cause of SCD in young athletes in the United States;
As per National Registry of SCD in Athletes - HCM accounted for 36% of all SCD events in young athletes (2)
Maron BJ et al. Circulation 2000.
Maron BJ et al. Circulation 2009.
5. Mechanisms of SCD in HCM
◦ Mediated primarily by VF
- Precipitated by runs of VT, rapid AF or accelerated AV conduction
◦ Asystole, PEA and advanced AV blocks have also been associated with SCD in HCM
Krikler DM et al. Br Heart J 1980
Chmielewski CA et al. Am Heart J 1977
7. Structural and electrical changes
Abnormal Ca handling
- Increased myofilament Ca+ sensitivity
- Persistence of Ca+ handling proteins
Myocyte disarray and fibrosis promoting re-entry
Intercalated disc disruption
8. Ischemia in HCM
SCD risk score and presence of
myocardial bridges were independent
risk factors for fatal ventricular
arrhythmias in patients with HCM.
The HCM–MB study. Güner A et al. Herz April 2023 Pelliccia F et al. J Clin Med 2022 Nov.
9. Autonomic dysfunction in HCM
U Limbruno et al. Eur Heart J 1998.
Selective impairment of HR variability with deep breathing and
Valsalva manoeuvre indicating decreased cardiac parasympathetic
activity.
10. Role of physical exertion
Effect of changes in the following have been implied:
- Sympathetic discharge
- Electrolyte/acid-base disturbances
Exercise-induced ventricular arrhythmias, present in 1-2% of
patients with HCM, are independently associated with SCD
(multivariable HR 3.14; P=0.01). – (2)
Maron BJ et al. Circulation 1982
Gimeno JR et al. Eur Heart J 2009
14. ◦ Aggregation of SCD in families of patients with HCM
◦ Most studies have used an age cut-off of 40-50 years and have considered only first-degree relatives (>1).
◦ In a systematic review conducted in 2010
Many studies did not demonstrate a significant association.
However, 3 recent large studies – Independent (but weak) predictor of SCD
The average hazard ratio of FHSCD was 1.27 (95% CI, 1.16–1.38).
Teare D. Br Heart J 1958
Maron BJ. Am J Cardiol 1978
Christiaans I et al. Systematic review of clinical risk markers. Europace 2010
15. ◦ HCM ICD registry, 383 patients with HCM underwent ICD
placement for primary prevention based on the presence of
atleast 1 of the conventional risk factors, with an appropriate
intervention rate for VT/VF of 3.6% per year over the
follow-up period.
◦ A substantial proportion of these patients underwent ICD
implantation based on the presence of only 1 conventional
risk factor.
◦ The rate of appropriate ICD interventions for patients
undergoing implantation based only on family history
was substantial (2.7 per 100 person-years) Maron BJ et al. JAMA 2007
16. Role of genetic studies
The effect of FHSCD on SCD is related to the genetic nature
of the disease.
Affected relatives share the same genetic defect and, to some
degree, have similar environmental exposures.
Few early studies of HCM pedigrees implicated certain
mutations as “malignant.”
However, subsequent studies of unselected consecutive
patients with HCM found no significant association
between the rate of SCD events and “malignant”
mutations.
Whether genetic information improves risk stratification
for SCD over and above phenotypic markers is not
known.
Marian AJ et al. J Cardiovasc Electrophysiol. 1998
19. ◦ Maximum Left Ventricular Wall Thickness (MLVWT)
Maximum end-diastolic dimension of any segment of LV measured in SAX view.
◦ In a systematic review of risk markers of SCD in HCM conducted in 2010, the average HR for severe LVH
was 3.1 ( 95% CI 1.81–4.4)
Christiaans I et al. Systematic review of clinical risk markers. Europace 2010
20. LIMITATIONS
Significant inter-observer variability on echocardiography.
Almost all the studies have considered it as a binary variable instead of a continuous variable.
The thickness of a single myocardial segment may not adequately represent the true burden of hypertrophy.
Hence, alternate scoring systems – Eg: Wigle scoring system. (1)
MLVWT measurements by echocardiography and MRI are discrepant. – (2)
Using MRI to estimate the HCM-SCD Risk led to reclassification of upto 14% of patients - (3)
Elliot PM et al. The Lancet 2001.
Bois JP et al. Am J Cardiol 2017.
Spiewak M et al. Sci Rep 2021.
21. Elliot PM et al. The Lancet 2001.
Wigle Scoring System
24. ◦ Spirito et al demonstrated that relative risk of SCD in patients with recent unexplained syncope (<6months)
was five-fold higher than that in patients without syncope.
However, older patients (≥40years of age) with remote episodes of syncope (>5years before initial
evaluation) did not show an increased risk of SCD. (1)
◦ In a multicentre longitudinal cohort study of 3675 patients followed up for 24313 patient-years,
On univariable Cox regression analysis, Unexplained syncope - Significantly associated with SCD. (2)
Spirito P et al. Circulation 2009
C. O’Mahony et al. Eur Heart J 2014
26. ◦ Most studies that demonstrated a significant association between NSVT and SCD defined NSVT as ≥3
consecutive ventricular beats at a rate of ≥120 beats/min lasting <30 seconds.
◦ The risk of SCD associated with NSVT may be lower in older patients.
Monserrat et al - NSVT in patients aged ≤30 years: 4-fold increase in the risk of SCD (univariable HR, 4.35;
95% CI, 1.54–12.28; P=0.006)
But no effect in older patients (univariable HR, 2.16; 95% CI, 0.82–5.69; P=0.1).
◦ Another study suggested that NSVT is predictive of SCD only when it occurs repeatedly or is associated
with symptoms.
Monserrat J et al. J Am Coll Cardiol 2003.
Spirito P et al. Circulation 1994.
27. Earlier studies failed to show a significant
association between NSVT and SCD, however
the wide confidence intervals indicated that an
association could not be excluded.
With increasing patient numbers in
more recent studies, NSVT proved to be a
significant independent risk factor for SCD,
especially in the young.
Christiaans I et al. Systematic review of clinical risk markers. Europace 2010
28. n = 160 HCM (ICD implanted)
86 (54%) patients had NSVT runs
21% patients with NSVT vs 8% without NSVT – Experienced ICD treated VT/VF
NSVT was significantly associated with ICD-treated VT/VF (adjusted HR, 3.98; P=0.0093)
NSVT was most predictive of future ICD shock for VT/VF when :
- FASTER (Rate > 200)
- LONGER (> 7 beats)
- FREQUENT (> 1 episode)
30. RR 2.1 (95% CI 1.1-3.7)
Likelihood of SCD was greater among patients
with LVOTO than among those without
obstruction, although the difference in the
annual rate of SCD was small (0.6% per year)
31. • 917 HCM patients
• Median follow-up of 61 months (30-99 months)
• Multivariable analysis - LVOTO was an independent predictor of SD/ICD, with HR 2.4 (p=0.003)
• LVOTO (>= 30mmHg) - Reduced 5-year survival from SCD and ICD discharge (91.4% vs. 95.7%).
• Magnitude of LVOTO was related to a higher occurrence of SCD/ICD,
RR per 20 mmHg = 1.36 (p = 0.001)
32. ◦ Similarly, in a study of 307 HCM patients with a mean follow up of 9.4 years
◦ On multivariate analysis – LVOTO independent predictor of SCD (p=0.003)
5-year :
89% vs 97%
10-year :
82% vs 92%
15-year :
78% vs 87%
Maki S et al. Am J Cardiol 1998.
Patients with LVOTO > 30mm Hg had a poorer SCD-free survival
33. Impact of septal reduction therapy on SCD
◦ A study from Toronto - 338 patients - Myectomy - only 4% mortality from SCD at 5 years - (1)
◦ Another study - Compared to matched non-operated HOCM patients, myectomy patients had superior SCD-
free survival (p=0.003) - (2)
Woo A et al. Circulation 2005
Ommen SR et al. J Am Coll Cardiol 2005
10 year SCD-free survival: 99% vs 89%
34. ◦ A similar trend has been observed also after ASA, with lower SCD rates (0.5%/year in the entire cohort,
0.6%/year in the group with expected high-risk) than the expected risk of 4% for the high-risk patients. – (1)
◦ In a meta-analysis comparing septal reductive therapies for HCM, similar low rates of all-cause mortality
and SCD were found following either ASA or surgical myectomy. – (2)
After adjustment for available baseline characteristics, the odds ratios for treatment effect on all-cause
mortality and SCD were 0.28 (95% CI 0.16–0.46) and 0.32 (95% CI 0.11–0.97), respectively, favoring ASA.
Jensen MK et al. Heart 2013
Leonardi AR et al. Circulation 2010.
36. ◦ A blunted systolic blood pressure response to exercise (SBPRE) was first noted in a study of 6 patients with
HCM in 1970
◦ Subsequently, in 129 patients - maximal symptom-limited treadmill exercise test.
Approximately, 1/3rd of patients exhibited an abnormal SBPRE - associated with a younger age and
a family history of SCD (FHSCD), but not LVOTO or severe hypertrophy.
◦ The exact mechanism behind exercise-induced hypotension is unclear, but hemodynamic studies suggest that
in the majority of cases, an inappropriate drop in systemic vascular resistance despite an appropriate
increase in cardiac output, is responsible.
Frenneaux MP et al. Circulation 1990
Counihan PJ et al. Circulation 1991
37. Sadoul N et al - Prognostic significance of abnormal SBPRE in 161 HCM patients aged <40 yrs.
Abnormal SBPRE :
Hypotensive SBPRE - Initial increase in systolic BP with a subsequent fall by peak exercise or a continuous
decrease in systolic BP of >20 mm Hg.
Flat response - Rise in systolic BP of <20 mm Hg during the whole exercise period.
Mean follow-up of 44 months - SCD in 12 patients:
3 (3%) in the normal blood pressure response group VS 9 (15%) in the ABPR group (P<.009)
No significant difference in the incidence of other recognized risk factors
38. However, not independently associated with SCD in any multivariable survival analysis
In the systematic review by Christiaans I et al, abnormal SBPRE failed to show a significant association with
SCD.
Christiaans I et al. Systematic review of clinical risk markers. Europace 2010
39. LV Apical Aneurysm (LVAA)
◦ Estimated prevalence in HCM: 2-5%
2D echo often unreliable in detecting smaller aneurysms compared to CMR
Rate of missed diagnosis compared to CMRI – Around 50% - (1,2)
◦ Contrast echocardiography - Equivalent detection rates compared to CMR – (3)
Recommended in patients with suboptimal 2D echo images.
◦ On follow-up of 93 HCM patients with LVAA, the SD/ICD event rate was 4.7%/year. (4)
However, size of the aneurysm was not shown to affect the risk of SCD (5)
Maron MS et al. Circulation 2008.
Yang K et al. Eur Heart J CV Imaging 2020.
Lee DZJ et al. JASE 2021.
Rowin EJ et al. JACC 2016.
Adamczak DM et al. Cardiol Rev 2018.
40. Systolic Dysfunction (Burnt-out HCM)
◦ In a multi-centre cohort of 3675 HCM patients – follow-up period of 24313 patient years
Exploratory univariable analysis - Fractional shortening was not significantly associated with SCD risk. – (1)
◦ However, compared to HCM with preserved EF, HCM-EF<50% was seen to have significantly higher
appropriate ICD interventions, resuscitated cardiac arrests and sudden death event rate.
20% of patients with EF <50% eventually had appropriate ICD therapy and importantly, over two-thirds of those
events occurred with EF 35% to 49% – (2)
C. O’Mahony et al. Eur Heart J 2014.
Rowin EJ et al. JACC 2020.
41. Other risk markers
◦ LA size, AF
LA size – Summative measure of abnormal diastolic function, MR and atrial arrhythmias
In patients without documented AF, LA size (>48mm) - Independent determinant of SCD risk - (1)
In a meta-analysis, AF – increased risk of SCD in HCM (RR 2.05, p = 0.01) – (2)
◦ Age
Traditionally - SCD preferentially in asymptomatic/mildly symptomatic children and adults < 35 years.
Spirito et al found that SCD risk decreases significantly with age – (3)
Minami Y et al. J Cardiol 2016
Rattanawong P et al. Journal of Interventional Cardiac Electrophysiol 2018
Spirito P et al. Circulation 2009.
Rowin EJ et al. JACC 2020.
42. CMR - LGE
◦ Chan RH et al assessed LGE in 1293 HCM patients – Median follow up of 3.3 years
Continuous relationship between extent of LGE and SCD/ICD event risk
LGE ≥15% of LV mass - 2-fold increase in SCD event risk in otherwise low-risk patients
LGE ≥15% of LV mass - Estimated likelihood for SCD events of 6% at 5 years
Absence of LGE was associated with lower risk for SCD events (adjusted HR, 0.39; P=0.02).
◦ Meta-analysis of 7 studies - Presence of LGE - increased risk for SCD (OR: 3.41; p < 0.001).
After adjusting for baseline characteristics, extent of LGE remained strongly associated with the
risk of SCD (HR adjusted: 1.36/10% LGE; p < 0.005)
Weng Z et al. JACC 2016.
43. The distribution of the LGE also plays an important predictive role
◦ The number of nonseptal LGE segments has been shown to be significantly related to VT/VF.
By contrast, septal LGE was not related to VT/VF in patients with HCM and LGE.
Amano Y et al. J Comput Assist Tomogr 2017.
Klopotowski M et al. Journal of Cardiology 2016.
44. ◦ 44 Normal individuals
34 Athletes
87 HCM-patients
29 HCM-patients with sudden death or cardiac arrest (HCM-CA).
◦ A risk score was proposed.
Optimal separation between HCM-CA <40 years and athletes was obtained by a risk score >/= 6
(Odds Ratio 345, sensitivity 85%, specificity 100%, p< 0.0001)
47. 2014
Risk prediction model using predictors independently
associated with SCD in published multivariable survival
analyses.
Inclusion of factors like MLVWT and LVOTO as
continuous variables.
Unique contribution of each risk factor to the
predicted SCD risk.
48.
49. ◦ The clinical implications of using the HCM-SCD Risk model were examined in 3066 patients with the
necessary data.
◦ The 5-year SCD risk estimates that correctly identified the maximum number of SCD endpoints at 5 years
and simultaneously minimized ICD implantation in patients without the SCD endpoint were :
≥6% for patients with ≥2 conventional risk factors
≥4% for patients with a single risk factor
◦ A 5-year SCD risk of ≥4% identified 71% of SCD endpoints with 30% ICD implants in patients
without SCD at 5 years.
- NNT 16
C. O’Mahony et al. Eur Heart J 2014
50.
51. 2020
The 2020 ACC/AHA guidelines revised the
previous 2011 recommendations
Integrated clinical + imaging based
recommendations for ICD.
Additions:
- Apical aneurysm (Major)
- EF </= 50% (Major)
- LGE >/= 15% on CMR
*Abnormal BP response was removed
53. Retrospective analysis of 784 HCM patients
During follow-up - 47 (6%) patients developed an SCD event
54.
55. Excluded from all studies. So no
data on the incidence of SCD/risk
stratification
56.
57. CASE
◦ Mr AJ 27 year old
◦ NYHA II dyspnea on exertion
◦ H/o Syncope – On walking – More during summers – 3 episodes
◦ No H/o cardiac arrest
◦ Family History : (?) Valvular disease – Operated (No documents)
Sudden cardiac death at 25 years of age
◦ Holter – No NSVTs
◦ ECHO: - Normal LV function, MLVWT – 22mm
- Peak LVOTO : 27mmHg at rest, 50 mmHg on Valsalva [On Metoprolol 50mg]
58. TAKE-HOME MESSAGES
HCM-SCD risk stratification is still evolving.
The predicted SCD risk from clinical markers should be further augmented with imaging findings
like CMR-LGE.
Individualised risk estimation using systems like HCM-SCD Risk which assimilate weighted
contributions from all proven risk factors need to be honed further to improve sensitivity.
Genetics may play a role in individualising risk prediction in the future.
59. Dr Barry J Maron and his son, Dr Martin S Maron
Interestingly, impaired myocardial oxygenation has been detected in carriers of HCM mutations prior to development of LV hypertrophy – PET MBF
Perfusion defects can be found in over half of patients - Concomitant epicardial CAD in around 10% of patients
Chronic or recurrent ischemic injury leading to replacement fibrosis, distinct from the progressive interstitial fibrosis which is typically found in HCM
SPECTRAL ANALYSIS OF HEART RATE VARIABILITY
In patients with hypertrophic obstructive cardiomyopathy, the reduction in the low frequency component at rest and the lack of increase in the low frequency
component and low to high frequency ratio during tilt are consistent with a dysfunction in afferent and/or efferent sympathetic activity
the impairment of sympathetic responsiveness during tilt was not quantitatively related to LVOTO, but rather to the extent of LVH
Prognostic significance of mutations in MyHC correlates with the extent of hypertrophy, their penetrance, and a high incidence of SCD.
However, this does not appear to be true for mutations in the cTnT gene. Since despite exhibiting mild hypertrophy, mutations in cTnT gene are associated with a high incidence of SCD.
In 2000
The cumulative risk 20 years after the initial evaluation was close to zero for patients with a wall thickness of 19 mm or less but almost 40 percent for wall thicknesses of 30 mm or more.
As compared with the other subgroups, patients with extreme hypertrophy were the youngest (mean age, 31 years), and most (41 of 43) had mild symptoms or no symptoms.
Significant association of increasing Wigle scores and SCD was noted in a study – 605 HCM patientsCox regression p=0·029, RR per category 1·30 [1·03–1·66] - (1)
2017 study
In 2003
LVOTO may mediate SCD either by causing severe reduction in cardiac output leading to electromechanical dissociation or by precipitating VT/VF though myocardial ischemia caused by increased LVEDP.
HR 2.4 (95% CI 1.4-4.4)
Despite concerns that the iatrogenic scar of ASA may act as an arrhythmogenic substrate that may potentiate the predisposition to ventricular tachyarrhythmia and SCD
1987-1994
Mid ventricular obstruction with supply demand mismatch and microvascular dysfunction – Apical aneurysm
ONLY SUBGROUP WHERE VT ABLATION EPICARDIAL OR ENDOCARDIAL CAN HELP SUBSTANTIALLY
Previous studies have indicated that the septal LGE includes not only myocardial scarring but also interstitial fibrosis and disorganized myocardial structures, which are related to LVOTO.
SIMULATION STUDIES - Show the impact of using a threshold of ≥3, ≥4, ≥5, ≥6 5-year SCD risk to implant an ICD
2019
ESC >4% cut-off ---- Sensitivity 58%, specificity 81%, NNT 10.3
LV apical aneurysms, extensive LGE and systolic dysfunction - These risk markers associated with ~25% of appropriate ICD therapies.
ESC SCD Risk = 5% vs 10%
Enhanced ACC/AHA = ICD – F/H/O SCD - MRI to enhance risk stratification