The pre-Socratics were early Greek philosophers who lived between the 6th and 5th centuries BCE. They sought rational explanations for the world rather than attributing its creation to gods. The Milesian school believed the physical world was composed of a single element or "arche." Thales proposed water was the arche, while Anaximander said it was the infinite and Anaximenes said it was air. Anaxagoras believed all things contained a portion of everything else. Pythagoras and his followers explored mathematics and believed in concepts like the harmony of the spheres. Heraclitus was known for saying all things are in constant change.