This study investigates the impact of climatic conditions in various regions of Iran on pavement fatigue cracking, emphasizing the relationship between temperature, humidity, and pavement performance. Over 300 analyses showed that rising temperatures and moisture levels contribute to increased alligator and longitudinal cracking in pavement, with distinct influences related to different climatic zones. The research recommends using specific asphalt mixtures and drainage systems to mitigate the adverse effects of temperature and humidity on pavement durability.