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FIBRINOLYTIC &
ANTIFIBRINOLYTIC DRUGS
FIBRINOLYTICS (THROMBOLYTICS)
Drugs used to dissolve (lyse) blood clots
(thrombi)
Examples:
• Streptokinase, urokinase, alteplase, reteplase
Uses
• Acute myocardial infarction - to recanalyze
thrombosed coronary artery
• Deep vein thrombosis: Thrombolytic therapy
helps to prevent pulmonary embolism.
• Pulmonary embolism: Fibrinolytics are used
to lyse the clot.
ANTIFIBRINOLYTICS
Antifibrinolytics inhibit fibrinolytic activity
Examples:
1. Epsilon amino–caproic acid (EACA)
• Used to control bleeding due to overdose of
fibrinolytics
• After tooth extraction and prostatic surgery
• In menorrhagia, hematuria and bleeding due
to surgery or obstetric complications
2. Tranexaemic acid
• Used to control bleeding due to excessive
fibrinolytic activity
• Also in tonsillectomy, prostatectomy, tooth
extraction, menorrhagia etc.

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26.fibrinolytics