This document summarizes a lecture on achieving global food and nutrition security in the 21st century. It outlines four key "game changers" needed: (1) partnerships to produce and expand access to affordable, nutrient-dense foods, (2) partnerships empowering small farmers, the hungry and women, (3) scaling sustainable circular food economy innovations, and (4) leaders inspiring action. It discusses issues like the burden of malnutrition, economic costs, and the need for new collaboration to reduce food waste from farm to fork. The goal is a paradigm shift to avoid a "food cliff" and ensure all people have access to sufficient, nutritious food.