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Vincent C. Bond, PhD
Professor and Chair, Microbiology, Biochemistry and
Immunology, Morehouse School of Medicine
PI, MSM RCMI G12 MBRC
President and CEO, Orunmila Pharma, Inc
Tel: 404-752-1862;
Email: (MSM) vbond@msm.edu
(Other) orunmilapharma@gmail.com
Dr. Bond, currently Professor and Chair of MBI at Morehouse School of Medicine (MSM), has
studied HIV pathogenesis for 25 years serving as editor and reviewer for several leading
virological journals, authoring/co-authoring over 150 scientific communications. These
communications include: 110+ abstracts/magazine articles/media presentations, ten patent
applications, eight granted patents, and 60+ publications, 31 of which are articles in peer-
reviewed journals focused on aspects of HIV pathogenesis research. He received his B.S.,
M.S., and Ph.D. at the Pennsylvania State University in Viral Genetics, and subsequently, did a
postdoctoral fellowship at the California Institute of Technology (Caltech) in Cell Biology. He
came to MSM in 1990 as Assistant Professor.
Research Interests
As one of the lead researchers on the HIV research team at MSM, he has developed evidence
that exosomes significantly contribute to immune activation, bystander CD4 T cell depletion, and
HIV propagation via bystander cell activation during HIV infection. The team has shown this to
occur through release of exosomes from HIV-infected cells that induce apoptosis in bystander
uninfected CD4+ T cells. In HIV infected, viremic patients, exosomes circulating in the plasma
were found to be enriched for a host of pro-inflammatory cytokines which induce immune
activation in naive and central memory CD4 and CD8 T cells, one of the hallmarks of of HIV
infection, and well established as one of the strongest predictors of HIV disease progression.
They have also shown the relevance of HIV exosomes to pathogenesis in a humanized mouse
model, and are developing similar data in the macaque model. This patented work has uniquely
positioned his group to decipher the triggering mechanisms underlying HIV disease. It has also
led to potential new targets for AIDS therapy, as well as having uncovered a potential
therapeutic antagonist against those cellular targets.
The described antagonist has been shown to modulate a cellular protein important in multiple
cellular processes, and deregulated in cancer, IBD, bacterial pathogenesis, and biofilm
formation. Dr Bond’s lab has formed a start-up company (Orunmila Pharma, Inc) that is
developing the therapeutic potential of the antagonist, initially targeting its cancer chemo-
preventive attributes.
Websites:
http://www.msm.edu/about_us/FacultyDirectory/MicrobiologyBiochemistryImmunology/V
incentBond/index.php
https://www.researchgate.net/profile/Vincent_Bond2?ev=hdr_xprf

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2016_0601-Bond-Bio-Summary

  • 1. Vincent C. Bond, PhD Professor and Chair, Microbiology, Biochemistry and Immunology, Morehouse School of Medicine PI, MSM RCMI G12 MBRC President and CEO, Orunmila Pharma, Inc Tel: 404-752-1862; Email: (MSM) vbond@msm.edu (Other) orunmilapharma@gmail.com Dr. Bond, currently Professor and Chair of MBI at Morehouse School of Medicine (MSM), has studied HIV pathogenesis for 25 years serving as editor and reviewer for several leading virological journals, authoring/co-authoring over 150 scientific communications. These communications include: 110+ abstracts/magazine articles/media presentations, ten patent applications, eight granted patents, and 60+ publications, 31 of which are articles in peer- reviewed journals focused on aspects of HIV pathogenesis research. He received his B.S., M.S., and Ph.D. at the Pennsylvania State University in Viral Genetics, and subsequently, did a postdoctoral fellowship at the California Institute of Technology (Caltech) in Cell Biology. He came to MSM in 1990 as Assistant Professor. Research Interests As one of the lead researchers on the HIV research team at MSM, he has developed evidence that exosomes significantly contribute to immune activation, bystander CD4 T cell depletion, and HIV propagation via bystander cell activation during HIV infection. The team has shown this to occur through release of exosomes from HIV-infected cells that induce apoptosis in bystander uninfected CD4+ T cells. In HIV infected, viremic patients, exosomes circulating in the plasma were found to be enriched for a host of pro-inflammatory cytokines which induce immune activation in naive and central memory CD4 and CD8 T cells, one of the hallmarks of of HIV infection, and well established as one of the strongest predictors of HIV disease progression. They have also shown the relevance of HIV exosomes to pathogenesis in a humanized mouse model, and are developing similar data in the macaque model. This patented work has uniquely positioned his group to decipher the triggering mechanisms underlying HIV disease. It has also led to potential new targets for AIDS therapy, as well as having uncovered a potential therapeutic antagonist against those cellular targets. The described antagonist has been shown to modulate a cellular protein important in multiple cellular processes, and deregulated in cancer, IBD, bacterial pathogenesis, and biofilm formation. Dr Bond’s lab has formed a start-up company (Orunmila Pharma, Inc) that is developing the therapeutic potential of the antagonist, initially targeting its cancer chemo- preventive attributes. Websites: http://www.msm.edu/about_us/FacultyDirectory/MicrobiologyBiochemistryImmunology/V incentBond/index.php https://www.researchgate.net/profile/Vincent_Bond2?ev=hdr_xprf