Molecular Biologist with over thirteen years of hands-on research experience, impactful writer and presenter, dynamic leader and enthusiastic team player with an eye for great ideas and a passion to move science in new directions seeks challenging opportunities beyond the bench.

1. OBJECTIVE
Molecular Biologist with over thirteen years hands-on research experience, impactful
writer and presenter, dynamic leader and enthusiastic team player with an eye for great
ideas and a passion to move science in new directions seeks challenging opportunities
beyond the bench.
EDUCATION
YALE UNIVERSITY New Haven, CT
PhD, Molecular, Cellular and Developmental Biology, Spring 2010
MS, Molecular, Cellular and Developmental Biology, Spring 2006
BRYN MAWR COLLEGE Bryn Mawr, PA
Post-Baccalaureate Pre-Medical Certificate, Spring 2002
SARAH LAWRENCE COLLEGE Bronxville, NY
BA, Liberal Arts, Spring 1998
EXECUTIVE SKILLS
➢ Innovative experimentalist with broad knowledge of and experience with
techniques and technologies across a range of biomedical fields including 3D
stem cell-based organoid systems, single-cell RNAseq and data analysis, CLARITY
and 3D confocal microscopy, prognostic IHC and microRNA analysis of patient
samples and more, combined with over a decade of hands-on tissue culture
experience with a wide variety of cell types and species, including iPS and ES cells,
primary culture and a range of gene expression systems.
➢ Demonstrated ability to think outside the box and work creatively and ambitiously
with team members, independently or in the lead, while maintaining a rigorous
standard for results-oriented programs with realistic expectations and timelines.
➢ Superior communication and interpersonal skills, including coherent technical
writing and dynamic PowerPoint presentations, with meticulous attention to form
and detail. Demonstrated ability to engage, inform and excite a variety of
audiences.
➢ Extensive software proficiency including Next Generation Sequencing data
analysis software (BaseSpace, Singulair, etc.), microscopy and image editing
software (Imaris, FluoView, etc.), genome browsers (e.g. UCSC Genome Browser)
as well as Microsoft Office Suite.
Sirie Godshalk PhD
415-465-2146 sirie.godshalk@gmail.com 3087 Calle Rosales, Santa Barbara, CA 93105

2. RESEARCH EXPERIENCE
UNIVERSITY OF CALIFORNIA, SANTA BARBARA Santa Barbara, CA
Winter 2014 – Current
Postdoctoral Scholar
Advisor: Kenneth S. Kosik
Developed robust and replicable stem cell-based culture models of human and
chimpanzee cortical development, including complex three-dimensional cerebral
organoids recapitulating various cell types and contextual architecture of the fetal brain,
in an effort to elucidate evolutionary modifications in pathways that contributed to the
evolution of the modern human brain, as well as to provide contextual disease modeling.
Established methods for comprehensive confocal imagery of developing organoids, as
well as single-cell RNAseq analysis to characterize cell types over time within organoids.
UNIVERSITY OF CALIFORNIA, LOS ANGELES Los Angeles, CA
Summer 2011 – Summer 2012
Postdoctoral Scholar
Advisor: Larry Simpson
Characterized the molecular architecture and function of the mitochondrial RNA editing
complex (RECC) of Leishmania tarentolae, a causative agent of Leishmaniasis, a
neglected tropical disease affecting millions in underserved countries across the globe.
Developed expression strategies for large-scale fermenter production and cryo-EM
imaging of cytoplasmically assembled subunits of the RECC with the goal of sufficiently
high-resolution structural imaging to facilitate targeted drug design.
YALE UNIVERSITY New Haven, CT
Spring 2005 – Summer 2010
Advisor: Frank J. Slack Ph.D.
Dissertation: MicroRNAs and Cancer: A two-part study on the roles of microRNAs in
oncogenic virus infection and melanoma
Examined and established roles of microRNAs in cancer and viral infection. Identified
and characterized a single-nucleotide polymorphism in a microRNA-binding site in the
KIT oncogene that correlated with a four-fold increased risk of acral melanoma in our
patient cohort. Discovered significant global down-regulation of cellular micrRNA
expression upon initial infection of primary B-cells by the Epstein-Barr herpes virus.
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO San Francisco, CA
Spring 2002 – Summer 2004
Staff Research Associate, Comprehensive Cancer
Center
Developed IHC protocols for diagnostic visualization of molecular markers in formalin-
fixed paraffin-embedded prostate cancer tissue, and investigated radio-sensitization of
cultured cells to therapeutic adenovirus infection.

3. AWARDS AND PROFESSIONAL ACTIVITIES
• Grant award: Yale Melanoma SPORE to investigate the role of microRNAs in melanoma 2009
• Patent Application: SNP rs17084733 as a risk marker for acral melanoma 2010
• Scholarship Award - Keystone Conference: MicroRNAs and Cancer 2011
• Yale Biotechnology and Pharmaceutical Society (YBPS) 2008-2010
• Student Research Mentor Yale University 2006-2007, 2009-2010
• Member International Society for Stem Cell Research
• Member American Association for the Advancement of Science
• Past Member American Association for Cancer Research
• Past Member New York Academy of Sciences
PUBLICATIONS
“Early primary cilium-autophagy-Nrf2 (PAN) axis activation commits human embryonic
stem cells to a neuroectoderm fate.” Jang J, Wang Y, Lalli M, Guzman E, Godshalk SE, Zhou
H, Kosik K; In review, 2015.
“A Long Non-Coding RNA Mediates the Notch Signaling Pathway During Neuronal
Development by miRNA Control.” Rani N, Jang J, Godshalk S, Lissi V, Paquette J, Kosik K;
In review, 2015.
“MicroRNA signatures differentiate melanoma subtypes.” Chan E, Patel R, Nallur S, Ratner
E, Bacchiocchi A, Hoyt K, Szpakowski S, Godshalk S, Ariyan S, Sznol M, Halaban R,
Krauthammer M, Tuck D, Slack FJ, Weidhaas JB.Cell Cycle. 2011 Jun 1;10(11):1845-52.
“A Variant in a MicroRNA Complementary Site in the 3'UTR of the KIT Oncogene Increases
Risk of Acral Melanoma”, Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro
AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban
R, Kidd KK, Weidhaas JB, Slack FJ. Oncogene. 2011 Mar 31;30 (13):1542-50.
“MicroRNAs and Melanoma”, Godshalk, S., and F. J. Slack to appear in the series, Current
Cancer Research, edited by Wafik El-Deiry. Submitted.
“MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference”,
Godshalk SE, Melnik-Martinez KV, Pasquinelli AE, Slack FJ. Epigenetics. 2010 Feb;5(2):
164-8.
“Epstein-Barr virus-mediated dysregulation of human microRNA expression”, Godshalk
SE, Bhaduri-McIntosh S, Slack FJ. Cell Cycle. 2008 Nov 15; 7(22):3595-600.

4. PRESENTATIONS
YALE UNIVERSITY New Haven, CT
Yale-New Haven Hospital Melanoma SPORE Seminar Series 2009
Molecular, Cellular and Developmental Biology Research in Progress Seminar 2008
Molecular Biophysics and Biochemistry Hall Seminar 2006 and 2007
KEYSTONE SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY Keystone, CO
MicroRNAs and Cancer, poster 2009
MicroRNAs and siRNAs: Biological Functions and Mechanisms, poster 2007
INTERNATIONAL ASSOCIATION FOR RESEARCH ON EPSTEIN-BARR VIRUS Boston, MA
Association Meeting, poster 2006
MARINE BIOLOGICAL LABORATORIES Woods Hole, MA
Molecular, Cellular and Developmental Biology Departmental Retreat, poster, 2005, 2008
and 2009
TEACHING EXPERIENCE
YALE UNIVERSITY New Haven, CT
Biotechnology, Teaching Fellow, Spring 2007 and 2008
Led discussions of journal articles for groups of 20-30 students, wrote and graded
assignments and exams.