An interdisciplinary consortium was formed between several Russian organizations to develop radiopharmaceutical approaches for effective diagnostics and therapy of prostate cancer. The consortium aims to improve production technologies for Tc-99m and Re-188 generators, develop new quality assurance procedures, and produce radiopharmaceuticals that specifically target prostate cancer receptors. They also plan to develop an educational program to train specialists in technetium applications for prostate radiodiagnostics. The new radiopharmaceuticals and trained specialists will help improve prostate cancer management in Russia.
своевременная диагностика и терапия данного заболевания до сих пор являются нерешенной клинической задачей. По данным на 2011 г., заболе-
ваемость раком простаты в России составила 10,7% (40 тыс. первичных случаев) мужского населения, причем в 60% случаев заболевание диа-
гностировали на поздней (III–IV) стадии, когда неизбежен процесс активного роста и распространения метастазов. Методы анатомической
визуализации при диагностике данного заболевания имеют низкую чувствительность и специфичность. Методы метаболической визуализации,
использующие в качестве маркера простатспецифический антиген (ПСА), также малоэффективны. В качестве маркера для диагностики и
лечения метастатического рака простаты предлагается рассматривать простатспецифический мембранный антиген (ПСМА). За рубежом
проходят клинические испытания наиболее перспективные диагностические радиофармпрепараты на основе малых пептидных молекул, моди-
фицированных мочевиной, которые отличаются наибольшим сродством к ПСМА. Отличительной особенностью этих соединений является их
благоприятная фармакокинетика, высокое и длительное накопление в опухоли и метастазах, быстрое выведение из организма.
Ключевые слова: метастатический рак предстательной железы, простатспецифический мембранный антиген, радиофармпрепараты.
(Для цитирования: Власова О.П., Герман К.Э., Крылов В.В., Петриев В.М., Эпштейн Н.Б. Новые радиофармпрепараты для диагности-
ки и терапии метастатического рака предстательной железы на основе ингибиторов простатспецифического мембранного антигена.
Вестник РАМН. 2015; 70 (3): 360–365. Doi: 10.15690/vramn.v70i3.1334)
11(4) 2020 ITJEMAST Multidisciplinary Research Articlesdrboon
Research papers 2020 Behavioral finance; Personality traits; Behavioral factors; Overconfidence bias; Locus of control; Decision-making; Biased behavior Carbon (CO2) emissions; Economic Growth; Energy consumption; Trade; ARDL Approach; Granger Causality; Energy use Pedestrian start-up time; Street crosswalk, Pedestrian traffic signals; Pedestrians traffic lights; zebra crossings; Intersection crossings Service Attributes; Relationship quality; Relationship outcomes; Banking services; Electronic Customer Relationship Management; Virtual relationships; eBanking; eCRM College town landscape; College town character; Campus community; Urban identity; College town space; Sense of a place; Public Space; University gardens; Cultural identity; Campus identity; Businesses in college towns Emotional quotient; Self-emotional appraisal; Workplace Advice Network (WAN) Centrality; Service Sector Organizations; Sociometric matrix; Interconnectivity of nodes
Slides presented at the Molecular Med Tri-Con 2018 Precision Medicine, "Emerging Role of Radiomics in Precision Medicine" (http://www.triconference.com/Precision-Medicine/)
Abstract
The goal of this talk is to discuss the role of data standards, and specifically the Digital Imaging and Communication in Medicine (DICOM) standard, in supporting radiomics research. From the clinical images, to the storage of image annotations and results of radiomics analysis, standardization can potentially have transformative effect by enabling discovery, reuse and mining of the data, and integration of the radiomics workflows into the healthcare enterprise.
Nano medicine is a field of new research area and this presentation for my research and describe about nano medicines, pros and cons, suggestions to development.
своевременная диагностика и терапия данного заболевания до сих пор являются нерешенной клинической задачей. По данным на 2011 г., заболе-
ваемость раком простаты в России составила 10,7% (40 тыс. первичных случаев) мужского населения, причем в 60% случаев заболевание диа-
гностировали на поздней (III–IV) стадии, когда неизбежен процесс активного роста и распространения метастазов. Методы анатомической
визуализации при диагностике данного заболевания имеют низкую чувствительность и специфичность. Методы метаболической визуализации,
использующие в качестве маркера простатспецифический антиген (ПСА), также малоэффективны. В качестве маркера для диагностики и
лечения метастатического рака простаты предлагается рассматривать простатспецифический мембранный антиген (ПСМА). За рубежом
проходят клинические испытания наиболее перспективные диагностические радиофармпрепараты на основе малых пептидных молекул, моди-
фицированных мочевиной, которые отличаются наибольшим сродством к ПСМА. Отличительной особенностью этих соединений является их
благоприятная фармакокинетика, высокое и длительное накопление в опухоли и метастазах, быстрое выведение из организма.
Ключевые слова: метастатический рак предстательной железы, простатспецифический мембранный антиген, радиофармпрепараты.
(Для цитирования: Власова О.П., Герман К.Э., Крылов В.В., Петриев В.М., Эпштейн Н.Б. Новые радиофармпрепараты для диагности-
ки и терапии метастатического рака предстательной железы на основе ингибиторов простатспецифического мембранного антигена.
Вестник РАМН. 2015; 70 (3): 360–365. Doi: 10.15690/vramn.v70i3.1334)
11(4) 2020 ITJEMAST Multidisciplinary Research Articlesdrboon
Research papers 2020 Behavioral finance; Personality traits; Behavioral factors; Overconfidence bias; Locus of control; Decision-making; Biased behavior Carbon (CO2) emissions; Economic Growth; Energy consumption; Trade; ARDL Approach; Granger Causality; Energy use Pedestrian start-up time; Street crosswalk, Pedestrian traffic signals; Pedestrians traffic lights; zebra crossings; Intersection crossings Service Attributes; Relationship quality; Relationship outcomes; Banking services; Electronic Customer Relationship Management; Virtual relationships; eBanking; eCRM College town landscape; College town character; Campus community; Urban identity; College town space; Sense of a place; Public Space; University gardens; Cultural identity; Campus identity; Businesses in college towns Emotional quotient; Self-emotional appraisal; Workplace Advice Network (WAN) Centrality; Service Sector Organizations; Sociometric matrix; Interconnectivity of nodes
Slides presented at the Molecular Med Tri-Con 2018 Precision Medicine, "Emerging Role of Radiomics in Precision Medicine" (http://www.triconference.com/Precision-Medicine/)
Abstract
The goal of this talk is to discuss the role of data standards, and specifically the Digital Imaging and Communication in Medicine (DICOM) standard, in supporting radiomics research. From the clinical images, to the storage of image annotations and results of radiomics analysis, standardization can potentially have transformative effect by enabling discovery, reuse and mining of the data, and integration of the radiomics workflows into the healthcare enterprise.
Nano medicine is a field of new research area and this presentation for my research and describe about nano medicines, pros and cons, suggestions to development.
Pathomics Based Biomarkers and Precision MedicineJoel Saltz
Role of Digital Pathology Data Science (Pathomics) in precision medicine. Features from billions or trillions of objects segmented from digital Pathology data can be employed to predict patient outcome and steer treatment.
Presentation at Imaging 2020, Jackson Hole, WY September 2016
Presentation about how much bioinformatics involved in the medical field. This was presented at the University of Colombo in 2007 for an undergraduate seminar
Digital Pathology: Precision Medicine, Deep Learning and Computer Aided Inter...Joel Saltz
In this presentation, I will survey the development of Digital Pathology methodology beginning with the 1997 virtual microscope prototype at Hopkins to current tools, methods and algorithms designed to display, analyze and classify whole slide imaging data. I will describe methods, tools and algorithms to extract information from Pathology images. These tools include ability to traverse whole slide images, segment nuclei, carry out deep learning region classification and characterize relationship between extracted features and morphological structures. I will also describe some of the research efforts that motivate development of these tools, the role Pathomics is playing in precision medicine research as well as the impact of Pathology Informatics on clinical practice and health care quality.
Presentation at the Department of Biomedical Informatics, University Pittsburgh Medical Center, April 27, 2018
14th International Conference and Exhibition on Nanomedicine and Pharmaceutic...Evelyn Smith
Conference Series Ltd organizes highly notable pharmaceutical conferences throughout the world. Currently we are bringing forth “14th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology” (NanoMed 2018) scheduled to be held during April 09-11, 2018 at Amsterdam, Netherlands. The conference gathers all the participants across the globe to attend and share their insights and convey recent developments in the field of Pharmaceutical Nanotechnology and Drug delivery. The main theme of the conference is “Emerging Importance of Nanomedicine & Nanotechnology to Drive the Pharma Industry”.
NanoPharma 2018 aims to bring together leading academic scientists, researchers, research scholars, fellow key decision makers and experts all-around the Academic Institutions, Healthcare Institutes, Pharmaceutical, Biotech, Biomedical, Formulation scientists and researchers making the congress a perfect platform to share experience, foster collaborations through the research talks & presentations to put forward many thought provoking strategies. It's a perfect stage to brainstorm, discover new ideas, search for new skills and a platform to show your capabilities and discoveries to the world. It also provides a premier interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions opted in the fields of Nanotechnology and Nanomedicine.
Conference Highlights:
Nanomedicines and Biomedical Applications | Drug Discovery and Designing | Pharmaceutical Nanotechnology | Regenerative Medicine and Tissue Engineering | Drug Delivery Research | Novel Drug Delivery Systems | Nano Pharmaceuticals | Nanobiotechnology | Graphene Medicine | Personalized Nanomedicine | Nanomedicine & Cancer | Pharmaceutical Companies and Markets | Business Opportunities in Nanotechnology
For more details Visit: http://nanotechnology.pharmaceuticalconferences.com/
Pathomics Based Biomarkers and Precision MedicineJoel Saltz
Role of Digital Pathology Data Science (Pathomics) in precision medicine. Features from billions or trillions of objects segmented from digital Pathology data can be employed to predict patient outcome and steer treatment.
Presentation at Imaging 2020, Jackson Hole, WY September 2016
Presentation about how much bioinformatics involved in the medical field. This was presented at the University of Colombo in 2007 for an undergraduate seminar
Digital Pathology: Precision Medicine, Deep Learning and Computer Aided Inter...Joel Saltz
In this presentation, I will survey the development of Digital Pathology methodology beginning with the 1997 virtual microscope prototype at Hopkins to current tools, methods and algorithms designed to display, analyze and classify whole slide imaging data. I will describe methods, tools and algorithms to extract information from Pathology images. These tools include ability to traverse whole slide images, segment nuclei, carry out deep learning region classification and characterize relationship between extracted features and morphological structures. I will also describe some of the research efforts that motivate development of these tools, the role Pathomics is playing in precision medicine research as well as the impact of Pathology Informatics on clinical practice and health care quality.
Presentation at the Department of Biomedical Informatics, University Pittsburgh Medical Center, April 27, 2018
14th International Conference and Exhibition on Nanomedicine and Pharmaceutic...Evelyn Smith
Conference Series Ltd organizes highly notable pharmaceutical conferences throughout the world. Currently we are bringing forth “14th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology” (NanoMed 2018) scheduled to be held during April 09-11, 2018 at Amsterdam, Netherlands. The conference gathers all the participants across the globe to attend and share their insights and convey recent developments in the field of Pharmaceutical Nanotechnology and Drug delivery. The main theme of the conference is “Emerging Importance of Nanomedicine & Nanotechnology to Drive the Pharma Industry”.
NanoPharma 2018 aims to bring together leading academic scientists, researchers, research scholars, fellow key decision makers and experts all-around the Academic Institutions, Healthcare Institutes, Pharmaceutical, Biotech, Biomedical, Formulation scientists and researchers making the congress a perfect platform to share experience, foster collaborations through the research talks & presentations to put forward many thought provoking strategies. It's a perfect stage to brainstorm, discover new ideas, search for new skills and a platform to show your capabilities and discoveries to the world. It also provides a premier interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions opted in the fields of Nanotechnology and Nanomedicine.
Conference Highlights:
Nanomedicines and Biomedical Applications | Drug Discovery and Designing | Pharmaceutical Nanotechnology | Regenerative Medicine and Tissue Engineering | Drug Delivery Research | Novel Drug Delivery Systems | Nano Pharmaceuticals | Nanobiotechnology | Graphene Medicine | Personalized Nanomedicine | Nanomedicine & Cancer | Pharmaceutical Companies and Markets | Business Opportunities in Nanotechnology
For more details Visit: http://nanotechnology.pharmaceuticalconferences.com/
2023-11-09 HealthRI Biobanking day_Amsterdam_Alain van Gool.pdfAlain van Gool
Examples of lessons learned in Omics-based biomarker studies from myself and colleagues in X-omics and EATRIS, for an audience of biobankers, researchers and diagnostic/clinical chemistry experts.
Scientific federation welcomes you to attend the 3rd World Summit on Toxicology & Applied Pharmacology which is going to be held in Saint Petersburg, Russian Federation during June 15-16, 2020. We cordially invite all the participants who are interested in sharing their knowledge and research in the area of Toxicology & Pharmacology.
Toxicology-2020 anticipates more than 300+ participants around the globe with thought provoking plenary sessions, keynote lectures, Oral Presentations and Poster Presentations. The attending delegates include International Editorial Board Members of related International Journals. This is an excellent opportunity for the delegates from international Universities and Institutes to interact with the world class Scientists.
This will bring together world leaders in their respective fields in the fascinating environment of Saint Petersburg, Russian Federation. Toxicology-2020 Conference is to explore on Current issues of Probing the Opportunities and Lucid Technologies in Toxicology and Applied Pharmacology. The main purpose of the Toxicology-2020 is to promote unique research and real-world Influence in an atmosphere of true international cooperation between international researches by bringing together new pharmacological and toxicological information again the world class scientists, International Communities and Industrial heads to discuss the latest developments and innovations in the fields of Toxicology & Pharmacology with colleagues from different countries and other parts of Russian Federation.
JALA Deputy Editor-in-Chief Edward Chow, Ph.D., University of Singapore, offers instruction for central message design, journal selection and proper manuscript composition. Originality, citations and the peer review process also are covered. This presentation is from the popular “JALA & JBS Author Workshop: How to Get Your Work Published,” SLAS2014 in San Diego.
MACROMOLECULAR COMPOUNDS AND GELS. A manual for students and graduate students of biotechnology training and medical universities (in Russian) Authors: Belova EV, German KE, Afanasyev AV, Slyusar OI, Solodova EV
2018 History of technetium studies in Russia Anna KuzinaKonstantin German
Lecture is about the History of technetium studies in Russia and Anna Kuzina 100 anniversary of birthday
Technetium separation in milligram, gram and kilogram ammounts 1957 - 1993
Proceedings and selected lectures 10th intern symp technetium rheniumKonstantin German
Proceedings and selected lectures of the 10th International Symposium on Technetium and Rhenium – Science and Utilization, October 3-6, 2018 - Moscow – Russia, Eds: K. German, X. Gaona, M. Ozawa, Ya. Obruchnikova, E. Johnstone, A. Maruk, M. Chotkowski, I. Troshkina, A. Safonov. Moscow: Publishing House Granica, 2018, 518 p.
ISBN 978-5-9933-0132-7 December 2018
Aleksey Buryak. WELCOME ADDRESS FROM IPCE - RUSSIAN ACADEMY OF SCIENCES Andrey Romanov. WELCOME ADDRESS FROM THE MINISTRY OF SCIENCE AND HIGHER EDUCATION OF RUSSIAN FEDERATION Mikhail Igorevich Panasyuk. ANNA KUZINA: BIOGRAPHY. K.E. German. PROF. ANNA FEDOROVNA KUZINA – 100TH ANNIVERSARY OF BIRTHDAY T. Yoshimura, M. Seike, H. Ikeda, K. Nagata, A. Ito, E. Sakuda, N. Kitamura, A. Shinohara PHOTOLUMINESCENCE SWITCHING OF NITRIDORHENIUM(V) COMPLEXES B. Grambow, X. Gaona, W. Runde, R. Konings, A.V. Plyasunov, L. Rao, A.L. Smith, E. Moore, M.-E. Ragoussi, J. Martinez-Gonzalez, I. Grenthe. CHEMICAL THERMODYNAMICS OF TECHNETIUM IN THE OECD/NEA UPDATE VOLUME E.S. Kulikova, Zh.K. Majed, D.V. Drobot, E.I. Efremova. HIGHLY SELECTIVE CATALYSTS BASED ON BIMETALLIC RHENIUM-RUTHENIUM COMPLEXES OBTAINED BY ALKOXYTECHNOLOGY E.S. Kulikova, D.V. Drobot, E.I. Efremova. THE FIRST EXAMPLE OF BI AND THREEMETALLIC ALKOXIDES CONTAINING RHENIUM AND RUTHENIUM T. Matsuzaki, H. Sakurai. A NEW PRODUCTION METHOD OF 99Mo BY MUON NUCLEAR TRANSMUTATION N. Budantseva, G. Andreev, A. Fedoseev THE U(VI), NP(VI) AND PU(VI) COMPLEXES WITH TcO4-, ReO4-. THE DIFFICULTIES IN ASSIGNING OF AnO22+ GROUPS VIBRATIONAL FREQUENCIES. J.S. McCloy, C. Soderquist, J. Weaver, Jason Lonergan. SPECTROSCOPIC STUDIES OF ALKALI PERTECHNETATES
Молекулы белков лежат в основе почти всех биологических процессов. Ученым всегда были любопытны как белки, участвующие в метаболических путях, так и молекулярные основы их функционирования. Однако в эру системной биологии еще больше внимание уделяется полному пониманию работы всей совокупности белков организма, его протеома. Все более важно, что мы не только понимаем все стороны данной функции, или функций, какого-либо белка, но и то, что наше знание распространяется на все компоненты изучаемой системы или организма и так далеко, насколько это возможно. Без всестороннего анализа информации попытки синтеза и расчетов не смогут выйти за рамки приближенной реальности.
Книга "Структура и функционирование белков: Применение методов биоинформатики" представляет собой уникальный обзор современного состояния вопросов моделирования структуры белков и предсказания их функции. Книга написана ведущими специалистами в своей области, прекрасно иллюстрирована и содержит ссылки на доступные серверы и другие ресурсы, которые читатель, возможно, захочет использовать в своей научной работе. В конце каждой главы описываются перспективы развития и наиболее актуальные проблемы соответствующих областей науки.
Физико-химические методы исследования в медицине и биологии: Учебное пособие / Медицинский университет Реавиз. Москва, Издательство «Граница», 2016. 120 с.
Данное учебное пособие написано в соответствии с содержанием Государственных образо-вательных стандартов и программой дисциплины “Физико-химические методы анализа” по специальности “Медицина”, направлению и программой большого практикума (раздел “Физикохимические методы анализа”), который выполняется студентами по специальности “Биология”.
В нем изложены основы физико-химических методов анализа. Рассмотрены условия и области применения методов, их достоинства и недостатки, ограничения, перспективы развития и другие особенности и характеристики.
В конце каждой главы дано описание практических работ, приведены контрольные вопросы.
Предназначено для студентов-медиков, биологов, химиков, аспирантов, научных работников и учителей школ.
2016 rsc-advance-tc-c-qinggao wang - 6 pp 16197-16202Konstantin German
We analyze the formation of transition metal (TM) carbides, as determined by the strength of TM–TM and
TM–C bonds, as well as lattice distortions induced by C interstitials. With increasing filling of the d-band of
TMs, TM–C bonds become increasingly weak from the left of the periodic table to the right, with fewer and
fewer C atoms entering the TMs lattice. Technetium (Tc) turns out to be a critical point for the formation of
carbides, guiding us to resolve a long-standing dispute. The predicted Tc carbides, agreeing with measured
X-ray absorption spectra, should decompose to cubic Tc and graphite above 2000 K. Consequently, we
show that what has been claimed as TcC (with rocksalt structure) is actually a high-temperature cubic
phase of elemental technetium.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
1. Interdisciplinary
consortium collaboration
for the development of
radiopharmaceutical
approach for effective
diagnostics and therapy of
prostate cancer in Russia
K. German1,2, O. Vlasova3, V. Petriev4, V. Skvortsov4, G.
Kodina5, A. Maruk5, N. Airapetova6, N. Epshtein6, N. Nerozin3,
A. Safonov1,2, V. Lebedev1, Ya. Obruchnikova1,2, Yu. Shevko3
1 - A.N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS, Moscow
2 - Medical Institute Reaviz, Moscow branch, Russia
3 - A. I. Leipunsky Institute for Physics and Power Engineering, Obninsk, Russia
4 - Medical Radiological Research Center of Ministry of Health of Russia, Obninsk,
Russia
5 - Burnazyan Federal Medical Biological Center of FMBA, Moscow, Russia
6 - National Research Nuclear University MEPhI, Obninsk, Russia
2. Consortium organigram
Direсtorate
A.N. Frumkin
Institute of Physical
Chemistry and
Electrochemistry RAS,
Moscow
Medical
Institute Reaviz,
Moscow branch,
Russia
Burnazyan Federal
Medical Biological
Center of FMBA,
Moscow, Russia
A. I. Leipunsky Institute for
Physics and Power
Engineering, Obninsk,
Medical Radiological
Research Center of
Ministry of Health of
Russia, Obninsk, Russia
National Research
Nuclear University
MEPhI, Obninsk,
Russia
Russia
Tc-99m for
prostate cancer
diagnostics and
Re-188 for treatment
3. A.N. Frumkin Institute of Physical
Chemistry and Electrochemistry RAS,
Moscow
Technetium chemistry laboratory
• K. German, Project CEO, Head of Tc
laboratory, PhD , Doc., Prof.
• A. Safonov, Deputy head of Tc laboratory, PhD
• Ya. Obruchnikova, PhD
• V. Tregubova, PhD student
• M. Glazkova
Innovation department
• V. Lebedev, General manager for innovations
Laboratory of new physical-chemical problems
• A. Tsivadze, Director of IPCE RAS, Academician
• A. Filyanin, liquid extraction group, PhD
• V. Tarasov, NMR analysis, Professor
Laboratory of substance radiation chemistry
• B. Ershov, Head of laboratory, corr. member
RAS, Professor
• E. Abkhalimov, PhD
• R. Solovov, PhD student
Laboratory of interphase boundaries and
electocatalysis
• V. Andreev, Head of laboratory, Professor
Laboratory of radioactive material analysis
• M. Grigoriev, Head of laboratory, Professor
4. • The main purpose of the Institute is to carry
out fundamental and applied scientific
research in various fields of physical chemistry,
electrochemistry, chemical resistance of
materials, radiochemistry and radiation
chemistry.
5. A. I. Leipunsky Institute for Physics and
Power Engineering, Obninsk, Russia
• O. Vlasova, N. Nerozin, Yu. Shevko, I. Zhuk
• multidisciplinary scientific organization,
conducting complex investigations of physical
and technical problems of nuclear science and
technology.
6. Medical Radiological Research Center
of Ministry of Health of Russia,
Obninsk, Russia
• V. Skvortsov, V. Petriev
• Mission: Development of concepts, regulatory
documents related to radiation safety of a human
and the environment, health security and
reduction of socioeconomic prejudice caused by
radiation.
• The Institute was founded in 1962 to develop and
improve methods of radiation diagnostics and
radiation therapy, prevention and treatment of
radiation injury, the study of the biological and
medical effects of ionizing radiation.
7. National Research Nuclear University
MEPhI, Obninsk, Russia
• N. Airapetova, N. Epshtein
• Development of analytical procedures
for quality control of
radiopharmaceuticals and staff training
• Mission: to generate, disseminate the use and to
preserve scientific knowledge aiming to address
global challenges of the XXI century, as well as to
provide innovative transformations in Russia
accompanying development of the country
competitiveness in the global energy and non-energy
high-tech markets.
8. Burnazyan Federal Medical Biological
Center of FMBA, Moscow, Russia
• G. Kodina, PhD, Department head
• A. Maruk, PhD, Laboratory Head
• Production of Tc-99m (for radiodiagnostics)
and Re-188 (for radiotherapy) isotopes and
preclinical medicine tests
• Fundamental and applied research in the field of radiation
medicine, radiobiology and radiation protection;
• Research in the field of biomedical technologies, radiopharmacy;
• Development of new radiation technologies (including photon
and neutron capture therapy);
• Research in the field of chemical and radiation safety in the use
of technology for special applications.
9. Medical Institute Reaviz,
Moscow branch, Russia
• K. German, Chair of Natural science, Professor
• A. Safonov, docent, PhD
• Ya. Obruchnikova, assistant prof., PhD
• V. Tregubova, PhD student
• Training of medical staff for modern medicine
“The main aim of Reaviz is the training of health care staff, of young people
who should become highly professional physicians in the nearest future. The
most important quality for these professionals should be the integration of the
greatest responsibility and the inner freedom of this profession, of scientific
research and practical achievements.” Rector of Samara Medical Institute
“REAVIZ”, Doctor of Medical Science, professor Nikolay A. Lyssov
10. What we intend to obtain
In the course of this project should be developed
• production technologies of 99mTc generators and high-value
188Re generators with reduced transport index,
• technologies of 188Re concentration, development of
analytical methods for detection of radioactive and
chemical impurities in the 188Re preparation,
• quality assurance of 99mTc and 188Re generator eluates
in accordance with the requirements of potential
radiopharmaceuticals based on them, specifically binds
to the receptor tissue of prostate cancer.
11. What we already have
for radionuclide imaging
• 2-18F-fluoro-2-deoxy-D-glucose (FDG);
• 111In-7E11 antibody (ProstaScint);
• 18F-fluorodihydrotestosterone (18F-FDHT);
• radioacetate analogs;
• radiocholine analogs;
• anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic
acid (anti-[18F]FACBC)
Production of Tc-99m (for radiodiagnostics) and Re-188
(for radiotherapy) isotopes were improved with
optimized generator design aimed to high specific activity
production.
12. • Potential consumer of radiopharmaceuticals
(RPh): medical institutions at various levels,
cancer medical centers, cancer clinics, licensed to
work with sources of ionizing radiation and
equipped with diagnostic equipment, SPECT or
PET.
• Objects of RPh application: patients with the
disease of prostate cancer (about 30 thousand
pers. / year).
• Over the past few years in Russia approximately
40,000 new cases of prostate cancer per year
were recorded, and only for 30% of them
brachytherapy is performed with an efficiency of
75%
13. Effective diagnostics and therapy of
prostate cancer is an important issue
for Russia due to constantly increasing
number of decease cases herein.
Rational development of new radiopharmaceuticals
for the management of advanced and metastatic
prostate cancer requires an improved cooperation
of the organization thus involved. For this reason an
interdisciplinary consortium collaboration for the
development of radiopharmaceutical approach is
established with principle aim to improve the
situation within the 3 coming years.
14. The development of new radiopharmaceuticals
and generators for the management of
advanced prostate cancer will help to improve
the treatment of this disease in Russia.
15. • Special educational interdisciplinary program for
specialist training for technetium application to
prostate radiodiagnostics is elaborated.
• The development of new radiopharmaceuticals
and generators for the management of advanced
prostate cancer will help to improve the treatment
of this disease in Russia.
• Innovative character of this project requires special
attention on staff training.
• New technologies worked out by Igor Zhuk and
Yury Shevko (A.I. Leipunsky Institute for Physics
and Power Engineering, Obninsk, Russian
Federation) are to be used in this project
17. What makes a good specialist?
Interest Competence
Objectivity Creativity
Self-criticism
Efficiency
18. Many issues written by leading scientists state
that the expert is endowed mainly the
following qualities, namely:
1) has a degree in the subject area;
2) has a positive experience with previous
expertise in the subject area;
3) must work at least 10 years;
4) objective;
5) must constantly improve their knowledge and
so on.
19. Is it true?
In our opinion, these qualities are of a formal
nature and do not meet the full competencies
that have been proposed by the European
community as one of the core competences for
professionals of the twenty-first century.
20. Five basic EU competencies were chosen as the most
necessary for the Expert of the XXI century :
1. Communication in the mother tongue.
2. Communication in foreign languages.
3. Mathematics skills and core competencies
(skills) in science and technology.
4. Information technology competence.
5. The ability to find new information and
produce new knowledge for expert’s
professional area.
21. Ask yourself: “Are you sure that You
have all this basic competencies?”
Or Do You think that the expert and specialist of
technetium application to prostate
radiodiagnostics do not need
this competencies?
Unfortunately, it is not a simple question.
Please, think about quantity of the wrong
diagnosis in different countries
23. • The PSMA markers are focus selection of the project
due to their ability not only for cancer but also for
methastatic object detection. Draw investigation
indicated that the prostate-specific membrane antigen
(PSMA) based markers could be the key substrate
matter for the solution of the problem. PSMA is highly
expressed in prostate cancer, and small-molecule
radiopharma-ceuticals targeting PSMA helps to rapidly
detect the location and extent of disease. Comparative
study provided with a selected row of substrates
including several MIP derivatives and some others.
Synthetic procedures were optimized for better yields,
purities and prices.
24. Expert assessments in Russia
• Expert assessments are applied with success
in various fields of human activity and find
their reflection in the works of such Russian
scientists as Azgaldov G.G., Beshelev S.D.,
Evlanov L.G., Gurvich F.G., Larichev O.I., Litvak
B.G., Novikov, D. A., Orlov, A.I., Raichman I.P.,
Sidelnikov Y.V., and many other authors
involved in problem of expert assessments.
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25. Evlanov L.G. thought that the expert
has the following requirements:
1) Competence;
2) Creativity;
3) Respect to the examination;
4) Conformism;
5) Constructive thinking;
6) Teamwork;
7) Self-criticism.
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26. In the work of Raichman A.P. and Azgldov G.G. the
quality of the expert has the following requirements:
1) Competence;
2) Interest;
3) Efficiency;
4) Objectivity.
The competence of the expert should be applied
to the object quality assessment (professional
competence) and methodology (qualitative
competence).
27. Data about the authors
• Zhuk Igor Aleksandrovich, PHD,
• Shevko Yuri Viktorovich,
e-mail: zz-38@yandex.ru
• (A. I. Leipunsky Institute for Physics and Power
Engineering, Obninsk, Russia)