The document summarizes the chemical mediators released during acute inflammation. These mediators include histamine, prostaglandins, nitric oxide, complement fragments, leukotrienes, interleukin-1, tumor necrosis factor, platelet activating factor, and chemokines. They promote vasodilation, increased vascular permeability, chemotaxis, leukocyte recruitment, fever, pain, and tissue damage. The mediators are released from mast cells, leukocytes, macrophages, and the plasma during inflammation and activate pathways such as the arachidonic acid pathway and complement system to propagate the inflammatory response.