This document discusses effective approaches for treating frequent users of emergency room services. It begins by noting that a small percentage of patients account for a large portion of healthcare resources. The frequent users are a heterogeneous group that may have mental health issues, complex medical conditions, or be seeking medication. The issues they present include financial strain, resource drain, and caregiver burnout. The document then examines case studies of specific frequent users and the approaches that were effective for their situations, such as engaging social services, using monitoring devices, and showing compassion. It stresses taking an open, inquisitive, flexible approach with each patient rather than a rigid one.