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From primary to tertiary care
An integrated care pathway for the
improved screening, assessment and
management of bipolar disorder
Dr. Nick Stafford, Consultant Psychiatrist
Lichfield, SSSFT
Disclosures
Pharmaceuticals
Astra Zenenca Ltd
Otsuka Ltd
Bristol Myers Squibb Ltd
Glaxo Smith Kilne Ltd
Pfizer Ltd
Eli Lilly Ltd
Lundbeck Ltd
Servier Laboratories Ltd
GW Pharma Ltd
Private Healthcare
Nuffield Health
Sutton Medical Consulting Rooms
Full list of business relationships at: www.uk.linkedin.com/pub/nick-stafford/17/7a4/54a/
Public Education/Professional Attitude
Praised by the public for going public Criticised by psychiatrists for going public
The management of bipolar disorder
Primary
care
Secondary
psychiatric
care
Inpatient
care
Tertiary
care
CAPTURE MISSED BIPOLAR
BEGIN TREATMENT EARLY
SHARED CARE AGREEMENTS
IMPROVE DIAGNOSTIC ACCURACY
BEGIN TREATMENT EARLY
ENHANCE SPECIALIST TREATMENT
Each element requires its own solutions
to improve overall outcomes
Aims of the bipolar care pathway
Project in Leicester
Health Care & Pharma
Mental Health
Trust
AstraZenecaPCT/CCGs
Charitable
Bipolar UK
Depression
Alliance
Rethink
Elements of the care pathway
Primary Care
Secondary
Care
Tertiary /
Specialised
Care
Increase awareness
Screening
Enhanced assessment
Psychosocial
interventions
Second opinions
Comprehensive
management plans
Pilot sites:
Lichfield (CMHT)
Stafford (IP)
Elements of the care pathway
Primary Care
Secondary
Care
Tertiary /
Specialised
Care
Primary care red flags
Presenting complaint:
Breast lump
Blood on toilet paper
Persistent cough
Depression
Could it be
Breast cancer?
Bowel cancer?
Lung cancer?
Bipolar?
How do we fix it, practically?
Education
Screening tool
not diagnostic
Always be
alert
A few extra
questions is
effective
Low index of
suspicion
History from
someone
close
The goal in primary care
“If a GP sees Depressive Disorder they
should have a reflex consideration of
bipolar disorder every time and ask
relevant questions to probe for it”
Primary care education in Staffs
Large group seminars (50+)
Individual practice seminars (3-15)
All Primary HCPs (not just GPs)
Internet e-Learning programme
Primary care screening options
• Ask more questions
– But which? (e.g. BRIDGE)
• Collateral history encouraged
• EMIS / Systm1 alerts (software templates)
– Surprisingly less popular with GPs
• Formal screen HCL-32
– How useful is it in practice?
– Frequency of use
• MDQ preferable?
HCL-32
• Most validated screen for hypomania
• Available in a range of languages
• Combines stem questions with screening
questions
• Distribute packs in primary care
Dimension and categories
Bipolar
Depression
Borderline
Anxiety
disorders
Addictions
HPA axis link?
Bipolar or unipolar depression
Borderline more likely if:
• Affective instability due to a marked reactivity of mood
(e.g. intense episodic dysphoria, irritability, or anxiety
usually lasting a few hours and sometimes more than a
few days)
• Identity disturbance: markedly and persistently
unstable self-image or sense of self
• Chronic feelings of emptiness
• Severe dissociative symptoms
• Frantic efforts to avoid real or imagined abandonment
• Recurrent suicidal threats, gestures or behaviour
• Self mutilating behaviour
Others (not exclusive)
• Anxiety
• ADHD
• PTSD
• Other personality disorders
• ‘Behavioural’
• Alcohol & substance misuse
If GP refers to the Clinic
• Standard GP letter (no forms to fill in)
• HCL-32 if appropriate, not mandatory
– MDQ if preferred
• Option to use the CPN
• Patient educated about possible bipolar
• Leaflets given (pre- and post-diagnosis)
• Mood diary before OPC appointment
Elements of the care pathway
Primary Care
Secondary
Care
Tertiary /
Specialised
Care
Specialised Bipolar Clinic
And supporting services
Psychosocial interventions
Tertiary service
Specialist services NICE 2006
DoH Guidelines 2007
• All trusts should provide:
– Specialist Mental Health Services
– Access to specialist advice from designated
experienced clinicians
– Referral on to tertiary services
• This can be provided with a local specialised
bipolar disorder clinic
Specialists within specialisms
• What does it mean?
• Increasingly differentiated with medical progress
• In psychiatry
– A need for generalists and specialists
– ADHD, ASD, EDS, CFS / PIER, AOT / CAMHS, MHSOP
• Medicine and surgery
– The norm in all areas
Nick Stafford, Allan Young, Tony Hale, Heinz Grunze, Daniel Smith, Francesc Colom
Pros and Cons of a Bipolar Clinic
Pros
• Reduces readmissions
• Increased satisfaction with
care
• Better continuity of care
• Improved education and
research
Cons
• Greater cost (not always)
• Not always more effective
• Fragmentation of care
• Tertiary setting distance
• Gaps in overall care
• Could focus less on functional
outcomes
• Need for greater peer support
and expertise
Time to hospital readmission for patients treated
in the mood disorder clinic v. standard out-patient care.
Kessing L V et al. BJP 2013;202:212-219
©2013 by The Royal College of Psychiatrists
N=158
Single manic episode
After 1st, 2nd or 3rd IP admiss
POM = time to readmission
HR = 0.60
95%CI = 0.37 – 0.97
P=0.034
Kessing L V et al. BJP 2013;202:212-219
Economic analysis
Specialised Bipolar Clinic Model
Secondary care
assessments and
management
Second opinions in
tertiary service
Psychosocial
interventions
Training and Research
MDT
Elements of the Clinic 1st Assessment
Pre-Interview Questionnaire
• Lengthy
• Patients enjoy completing
• Structure similar to semi-
structured interview
Semi-Structured Interview
• Detailed focus on moods
• Predominant Polarity
• Bipolarity Index
• Detailed medication history
• Comorbidities identified
TO IMPROVE DIAGNOSTIC ACCURACY AND CARE PLAN
COMPREHENSIVENESS
Semi structured assessment
• Face to face interview:
– Questionnaire structure maintained
– Clarify pre-interview questionnaire
– Extra detail were needed
– Are diagnostic criteria met? Listed in conclusion.
– Bipolar I, II etc…
– Predominant Polarity & Polarity Index
– Review of comorbidity
• Axis I + addictions
• Axis II – IPDE
Missed diagnosis of bipolar
• Variable figures: >15% RDD in primary care
• Impact of untreated episodes are manifold
• Relationship breakdown
• Occupational breakdown
• Increased use of CMHT services
• Increased use of inpatient services
• Kindling in the untreated worsens prognosis
MDT Approach
MDT Members
•Consultants
•Higher ST trainees
•Non-medical prescribers
•Visiting clinicians
•CPN
•OT (BPE)
•Social Worker
Psychosocial interventions
• Training for all IP & CMHT staff
– Psychoeducation
– Functional remediation
– IPSRT (Interpersonal Social Rhythm Therapy)
– DBT (Dialectical Behavioural Therapy)
– FFT (Family Focused Therapy)
Bipolar Psychoeducation
Survival curve on time to recurrence.
Colom F et al. BJP 2009;194:260-265
BPE group cf. Control group:
Fewer recurrences
3.86 v. 8.37, F=23.6, P<0.0001
Less time acutely ill
154 v. 586 days, F=31.66, P=0.0001
Less hospitalised days (median)
45 v. 30, F=4.26, P=0.047
The philosophy of the pathway design
Apply what is
known
Iterative design
The model can
be applied
anywhere
Appliance of
science
If GP/Psychiatrist refers to the Clinic
Standard summary letter
HCL-32 encouraged if appropriate
Patient educated about possible diagnosis
Leaflets given (pre- and post-diagnosis)
Mood diary from referral to OPC appointment
Elements of management
Comprehensive report
Clarity of diagnosis &
management
Psychoeducation &
Evidence-based
management plan
Multi-axial diagnoses
& co-morbidities managed
Health advice
Quality information
Management with GP
Elements of the care pathway
Primary Care
Secondary
Care
Tertiary /
Specialised
Care
Management algorithms
• International Guidelines for bipolar treatment
– BAP
– WFSBP
• Weekly OPC initially if necessary
• Management of comorbidity
• Lifestyle advice
• Psychoeducation (online and face to face)
• MDT approach and enhanced capacity
Structure of South Leicestershire
outpatient clinics now
CMHT
Outpatient
Clinic
Services
OPC services
Assessment
clinic
Bipolar
disorder
specialised
clinic
Integrated
depression
clinic
(at a later date)
Generic Specialised
Training
In clinic
experience
Psychiatry
trainees
GP trainees
NMPs
Students
Psychosocial
interventions
Psycho
Education
IPSRT
DBT
FFT
Medication
Workshops
Forums
NMS skills
General
training
Medical
student
Psychiatric
trainees
Nurses
Other
CMHT/IP
members
Research
In development
• New Psychoeducation Course
• Web based support
• App development
• New manuals for psychosocial interventions
• Research
Media attention & public education
Thank you

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Integrated Care Pathway for Bipolar Disorder. Seminar to the Westgate GP Practice, Lichfield, Staffs, UK.

  • 1. From primary to tertiary care An integrated care pathway for the improved screening, assessment and management of bipolar disorder Dr. Nick Stafford, Consultant Psychiatrist Lichfield, SSSFT
  • 2. Disclosures Pharmaceuticals Astra Zenenca Ltd Otsuka Ltd Bristol Myers Squibb Ltd Glaxo Smith Kilne Ltd Pfizer Ltd Eli Lilly Ltd Lundbeck Ltd Servier Laboratories Ltd GW Pharma Ltd Private Healthcare Nuffield Health Sutton Medical Consulting Rooms Full list of business relationships at: www.uk.linkedin.com/pub/nick-stafford/17/7a4/54a/
  • 3. Public Education/Professional Attitude Praised by the public for going public Criticised by psychiatrists for going public
  • 4. The management of bipolar disorder
  • 5. Primary care Secondary psychiatric care Inpatient care Tertiary care CAPTURE MISSED BIPOLAR BEGIN TREATMENT EARLY SHARED CARE AGREEMENTS IMPROVE DIAGNOSTIC ACCURACY BEGIN TREATMENT EARLY ENHANCE SPECIALIST TREATMENT Each element requires its own solutions to improve overall outcomes Aims of the bipolar care pathway
  • 6. Project in Leicester Health Care & Pharma Mental Health Trust AstraZenecaPCT/CCGs Charitable Bipolar UK Depression Alliance Rethink
  • 7. Elements of the care pathway Primary Care Secondary Care Tertiary / Specialised Care Increase awareness Screening Enhanced assessment Psychosocial interventions Second opinions Comprehensive management plans Pilot sites: Lichfield (CMHT) Stafford (IP)
  • 8. Elements of the care pathway Primary Care Secondary Care Tertiary / Specialised Care
  • 9. Primary care red flags Presenting complaint: Breast lump Blood on toilet paper Persistent cough Depression Could it be Breast cancer? Bowel cancer? Lung cancer? Bipolar?
  • 10. How do we fix it, practically? Education Screening tool not diagnostic Always be alert A few extra questions is effective Low index of suspicion History from someone close
  • 11. The goal in primary care “If a GP sees Depressive Disorder they should have a reflex consideration of bipolar disorder every time and ask relevant questions to probe for it”
  • 12. Primary care education in Staffs Large group seminars (50+) Individual practice seminars (3-15) All Primary HCPs (not just GPs) Internet e-Learning programme
  • 13. Primary care screening options • Ask more questions – But which? (e.g. BRIDGE) • Collateral history encouraged • EMIS / Systm1 alerts (software templates) – Surprisingly less popular with GPs • Formal screen HCL-32 – How useful is it in practice? – Frequency of use • MDQ preferable?
  • 14. HCL-32 • Most validated screen for hypomania • Available in a range of languages • Combines stem questions with screening questions • Distribute packs in primary care
  • 16. Bipolar or unipolar depression
  • 17. Borderline more likely if: • Affective instability due to a marked reactivity of mood (e.g. intense episodic dysphoria, irritability, or anxiety usually lasting a few hours and sometimes more than a few days) • Identity disturbance: markedly and persistently unstable self-image or sense of self • Chronic feelings of emptiness • Severe dissociative symptoms • Frantic efforts to avoid real or imagined abandonment • Recurrent suicidal threats, gestures or behaviour • Self mutilating behaviour
  • 18. Others (not exclusive) • Anxiety • ADHD • PTSD • Other personality disorders • ‘Behavioural’ • Alcohol & substance misuse
  • 19. If GP refers to the Clinic • Standard GP letter (no forms to fill in) • HCL-32 if appropriate, not mandatory – MDQ if preferred • Option to use the CPN • Patient educated about possible bipolar • Leaflets given (pre- and post-diagnosis) • Mood diary before OPC appointment
  • 20. Elements of the care pathway Primary Care Secondary Care Tertiary / Specialised Care
  • 21. Specialised Bipolar Clinic And supporting services Psychosocial interventions Tertiary service
  • 22. Specialist services NICE 2006 DoH Guidelines 2007 • All trusts should provide: – Specialist Mental Health Services – Access to specialist advice from designated experienced clinicians – Referral on to tertiary services • This can be provided with a local specialised bipolar disorder clinic
  • 23. Specialists within specialisms • What does it mean? • Increasingly differentiated with medical progress • In psychiatry – A need for generalists and specialists – ADHD, ASD, EDS, CFS / PIER, AOT / CAMHS, MHSOP • Medicine and surgery – The norm in all areas
  • 24. Nick Stafford, Allan Young, Tony Hale, Heinz Grunze, Daniel Smith, Francesc Colom
  • 25. Pros and Cons of a Bipolar Clinic Pros • Reduces readmissions • Increased satisfaction with care • Better continuity of care • Improved education and research Cons • Greater cost (not always) • Not always more effective • Fragmentation of care • Tertiary setting distance • Gaps in overall care • Could focus less on functional outcomes • Need for greater peer support and expertise
  • 26. Time to hospital readmission for patients treated in the mood disorder clinic v. standard out-patient care. Kessing L V et al. BJP 2013;202:212-219 ©2013 by The Royal College of Psychiatrists N=158 Single manic episode After 1st, 2nd or 3rd IP admiss POM = time to readmission HR = 0.60 95%CI = 0.37 – 0.97 P=0.034
  • 27. Kessing L V et al. BJP 2013;202:212-219 Economic analysis
  • 28. Specialised Bipolar Clinic Model Secondary care assessments and management Second opinions in tertiary service Psychosocial interventions Training and Research MDT
  • 29. Elements of the Clinic 1st Assessment Pre-Interview Questionnaire • Lengthy • Patients enjoy completing • Structure similar to semi- structured interview Semi-Structured Interview • Detailed focus on moods • Predominant Polarity • Bipolarity Index • Detailed medication history • Comorbidities identified TO IMPROVE DIAGNOSTIC ACCURACY AND CARE PLAN COMPREHENSIVENESS
  • 30. Semi structured assessment • Face to face interview: – Questionnaire structure maintained – Clarify pre-interview questionnaire – Extra detail were needed – Are diagnostic criteria met? Listed in conclusion. – Bipolar I, II etc… – Predominant Polarity & Polarity Index – Review of comorbidity • Axis I + addictions • Axis II – IPDE
  • 31. Missed diagnosis of bipolar • Variable figures: >15% RDD in primary care • Impact of untreated episodes are manifold • Relationship breakdown • Occupational breakdown • Increased use of CMHT services • Increased use of inpatient services • Kindling in the untreated worsens prognosis
  • 32. MDT Approach MDT Members •Consultants •Higher ST trainees •Non-medical prescribers •Visiting clinicians •CPN •OT (BPE) •Social Worker
  • 33. Psychosocial interventions • Training for all IP & CMHT staff – Psychoeducation – Functional remediation – IPSRT (Interpersonal Social Rhythm Therapy) – DBT (Dialectical Behavioural Therapy) – FFT (Family Focused Therapy)
  • 34. Bipolar Psychoeducation Survival curve on time to recurrence. Colom F et al. BJP 2009;194:260-265 BPE group cf. Control group: Fewer recurrences 3.86 v. 8.37, F=23.6, P<0.0001 Less time acutely ill 154 v. 586 days, F=31.66, P=0.0001 Less hospitalised days (median) 45 v. 30, F=4.26, P=0.047
  • 35. The philosophy of the pathway design Apply what is known Iterative design The model can be applied anywhere Appliance of science
  • 36. If GP/Psychiatrist refers to the Clinic Standard summary letter HCL-32 encouraged if appropriate Patient educated about possible diagnosis Leaflets given (pre- and post-diagnosis) Mood diary from referral to OPC appointment
  • 37. Elements of management Comprehensive report Clarity of diagnosis & management Psychoeducation & Evidence-based management plan Multi-axial diagnoses & co-morbidities managed Health advice Quality information Management with GP
  • 38. Elements of the care pathway Primary Care Secondary Care Tertiary / Specialised Care
  • 39. Management algorithms • International Guidelines for bipolar treatment – BAP – WFSBP • Weekly OPC initially if necessary • Management of comorbidity • Lifestyle advice • Psychoeducation (online and face to face) • MDT approach and enhanced capacity
  • 40. Structure of South Leicestershire outpatient clinics now CMHT Outpatient Clinic Services OPC services Assessment clinic Bipolar disorder specialised clinic Integrated depression clinic (at a later date) Generic Specialised
  • 43. In development • New Psychoeducation Course • Web based support • App development • New manuals for psychosocial interventions • Research
  • 44. Media attention & public education Thank you

Editor's Notes

  1. Time to hospital readmission for patients treated in the mood disorder clinic v. standard out-patient care.