The document discusses the cell cycle and cell division. It begins by listing the chromosome numbers of various organisms. It then describes the two main phases of the cell cycle as interphase and mitosis. Interphase is further divided into G1, S, and G2 phases. The S phase involves DNA replication where each DNA molecule forms two DNA molecules. Mitosis is divided into prophase, metaphase, anaphase and telophase where the chromosomes align and separate. The document also discusses the key events that occur during each phase of mitosis.
Infer the significance of cell division.
Differentiate a DNA molecule, a chromosome, and a chromatid.
Characterize the phases of the cell cycle and their control points.
Describe the major events associated with stages of mitosis.
Explain the process of cytokinesis.
Learning Objectives
Describe the role of apoptosis in the life cycle of a cell.
Relate cancer as a result of the malfunction of the cell during the cell cycle.
Infer the significance of cell division.
Differentiate a DNA molecule, a chromosome, and a chromatid.
Characterize the phases of the cell cycle and their control points.
Describe the major events associated with stages of mitosis.
Explain the process of cytokinesis.
Learning Objectives
Describe the role of apoptosis in the life cycle of a cell.
Relate cancer as a result of the malfunction of the cell during the cell cycle.
The following power point presentation talks about neural control and coordination in humans. In this, we study about neurons, the conduction of nerve impulse, about Central Nervous System and also about sense organs
Diversity of cell size & shape By KK Sahu SirKAUSHAL SAHU
SYNOPSIS
Introduction to cell
Historical Aspects
Cell Diversity
Types Of Cell Diversity
Cell Diversity In Origin
Cell Diversity In size
Cell Diversity In Shape
Some Other Types
5) Differentiation And Specialisation Of Cell Diversity
6) Conclusion
7) References
It is the presentation on the MEIOSIS phase of the Cell division.
It includes all the details and definitions that are related to the topic of meiosis with the labelled diagrams.
If you have any query or a question, you may ask in the comment box.
thanks.
Cell as basic unit of life ppt 88 slidesICHHA PURAK
This Power point presentation describes Cell as basic unit of life. The slides provide information about Discovery of cell,cell theory,number,size,shape and cell types .Differentiates prokaryotic and eukaryotic cell types and point out major differences in plant and animal cell and also about structure and function of cell organelles
The following power point presentation talks about neural control and coordination in humans. In this, we study about neurons, the conduction of nerve impulse, about Central Nervous System and also about sense organs
Diversity of cell size & shape By KK Sahu SirKAUSHAL SAHU
SYNOPSIS
Introduction to cell
Historical Aspects
Cell Diversity
Types Of Cell Diversity
Cell Diversity In Origin
Cell Diversity In size
Cell Diversity In Shape
Some Other Types
5) Differentiation And Specialisation Of Cell Diversity
6) Conclusion
7) References
It is the presentation on the MEIOSIS phase of the Cell division.
It includes all the details and definitions that are related to the topic of meiosis with the labelled diagrams.
If you have any query or a question, you may ask in the comment box.
thanks.
Cell as basic unit of life ppt 88 slidesICHHA PURAK
This Power point presentation describes Cell as basic unit of life. The slides provide information about Discovery of cell,cell theory,number,size,shape and cell types .Differentiates prokaryotic and eukaryotic cell types and point out major differences in plant and animal cell and also about structure and function of cell organelles
This presentation include the process of cell division. It hope it will helpful for all the medical students. Cell division is the series of events of equally dividing of one single mother cell into two identical daughter cell. Cell cycle and cell division terms are alternately used. Cell division is an important part of the all living processes.
At the time of cell division, RNA replication is a natural process.
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells.
These events include the duplication of its DNA (DNA replication) and some of its organelles, and subsequently the partitioning of its cytoplasm and other components into two daughter cells in a process called cell division.
There are two types of cell division
A) Mitosis and Binary fission – (Asexual reproduction) and B) Meiosis – (Sexual reproduction)
In prokaryotic cell, the cell division occurs via a process termed as Binary fission.
• In eukaryotic cell, the cell cycle can be divided in two periods i.e Interphase and Mitosis.
• During Interphase, the cell grows and DNA is replicated.
During Mitotic phase, the replicated DNA and cytoplasmic contents are separated, and cell divides.
The duration of cycle varies from hours to years. A typical human cell cycle has duration of 24 hours.
Some cells, such as skin cells, are constantly going through cell cycle, while other cells may divide rarely.
Some cells don’t grow and divide once they mature for ex. Neuron
Eukaryotic cell have a more complex cell cycle than prokaryotic cell.
cell division - Mitosis in plants final.pptReddykumarAv
mitosis is used for almost all of your body’s cell division needs. It adds new cells during development and replaces old and worn-out cells throughout your life. The goal of mitosis is to produce daughter cells that are genetically identical to their mothers, with not a single chromosome more or less.
cell division - Mitosis in plants final.pptReddykumarAv
mitosis is used for almost all of your body’s cell division needs. It adds new cells during development and replaces old and worn-out cells throughout your life. The goal of mitosis is to produce daughter cells that are genetically identical to their mothers, with not a single chromosome more or less.
Rhode Island is the smallest U.S. state. It is bordered by Massachusetts on the north and east and Connecticut on the west. Rhode Island is home to a tremendous amount of visitor attractions and amenities within its borders. With beautiful beaches, exciting cultural attractions and a renowned dining scene, the Ocean State is a perfect spot for a visit.
Harvard University is a privateresearch University in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the John Harvard, it is the oldest institution of higher learning in the United States and among the most prestigious in the world.
The Museum of Art, RISD Museum is an art museum integrated with the Rhode Island School of Design, in Providence, Rhode Island, US.The museum was co-founded with the school in 1877, and still shares multiple buildings and facilities. Visiting this museum is a feast to art lovers.
The Breakers is the grandest of Newport's summer cottages in Rhode Island, USA. and a great tourist place and the present cost of the mansion may be more than 150 million dollars.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
15. S phase
During S phase DNA undergoes replication & each
DNA molecule forms two DNA molecules
16. Synthetic phase
• Each chromosome has single DNA.
During S phase DNA undergoes
replication & each DNA molecule forms
two DNA molecules
• Centriole undergoes replication
• There are the changes in animal cells
21. Mitosis
• It has two steps
• 1.Karyokinensis
• It is the division of nucleus
• 2.Cytokinensis
• It is the division of the cytoplasm
22. karyokinensis
• It has four phases
• 1. Prophase
• 2. Metaphase
• 3. Anaphase
• 4. Telophase
23. Prophase
1.Condensation of chromatin into
Compact chromosomes .
Each chromosome has two
chromatids,which are attached at the
centromere
2.Centrioles move towards the opposite
poles & initiation of the formation of the
mitotic spindle
3. At the end of the prophase nucleolus,
nuclear membrane disappear
24.
25. Events in prophase
• 1.Condensation of chromatin into
Compact chromosomes .
Each chromosome has two
chromatids,which are attached at the
centromere
• 2.Centrioles move towards the opposite
poles & initiation of the formation of the
mitotic spindle
3. At the end of the prophase nucleolus,
nuclear membrane disappear
29. kinetochore
These are the small disc shaped structures at the
surface of the centromere
These structures serve as the sites of the
attachment of spindle fibers to the chromosomes
centromere
30. Key features of Metaphase
• Chromosomes are spread through out
the cytoplasm of the cell due to the
disintegration of the nuclear membrane
• Condensation of the chromosomes is
completed & they can be clearly seen
under the microscope
• Chromosomes move towards center of
the cell &they lie at the equatorial plate
31. Metaphase plate
• The plane
alignment of the
chromosomes at
metaphase is
referred as
metaphase plate
43. Questions
• Q1.Generally cell has single nucleus.Why some cells
have many nuclei?
• A.Nuclear division is not followed by cytoplasmic
division
• Q2.Human cell which is undergoing mitosis has 46
chromosomes. How many chromosomes will the cell
have at GIphase, after S phase,after M phase
• A. In all phases 46 chromosomes
• Q3 A cell has 14 DNA molecules. How many DNA
molecules does the cell consist in G1phase,G2 phase
respectively
• A. GI phase- 14
• G2 phase -28