The document summarizes the development of the Regional Innovation Strategy (RIS) for the South Moravian Region of the Czech Republic. It discusses three key points: 1) How the RIS has matured in its strategic focus over three iterations from 2002-2009. 2) The multilevel governance process used to organize participation from stakeholders across administration, universities, businesses and other actors. 3) The main internal and external factors for the success of the RIS, including partnership, EU funding, and commitment from relevant actors.