The document discusses the diagnosis and management of acute severe asthma. Key points include: - Physical exam should check pulse, respiratory rate, use of accessory muscles, and bilateral rhonchi. - Differential diagnosis to consider includes acute exacerbation of COPD, acute left ventricular failure, and pulmonary embolism. - Preferred initial treatment is salbutamol nebulization, steroids (methylprednisolone IV), and supplemental oxygen. - Other supportive therapies include inhaled beta agonists, aminophylline IV, and magnesium sulfate. Close monitoring for side effects is important.