antimicrobial resistant short presentation

1. SHIV VARAN SINGH
VBM(M.V.Sc)
M-5547
ANTIMICROBIAL RESISTANT:A
COMLPEX ISSUE

2. WHY RESISTANCE IS A CONCERN
• Resistant organisms lead to treatment failure
• Increased mortality
• Resistant bacteria may spread in Community
• Low level resistance can go undetected
• Added burden on healthcare costs
• Threatens to return to pre-antibiotic era
• Selection pressure

3. ANTIMICROBIAL RESISTANCE MECHANISM
Intrinsic (Natural) Acquired
Genetic Methods
Chromosomal Methods
Mutations
Extra chromosomal Methods
Plasmids

4. INTERACTION OF BACTERIA
WITH ANTIBIOTICS

5. ORIGIN OF ANTIMICROBIAL
RESISTANCE DETERMINANTS
Animal
pathogen

6. RESISTANCE TO AN
ANTIBIOTIC CAN BE ACQUIRED

7. SELECTION OF A RESISTANT
BACTERIAL POPULATION
• PRE-EXISTING SELECTION(RESISTOME)
• MUTANT ONE SELECTED(SUBSISTOME)
• CONCENTRATION BASIS

8. DISSEMINATION OF BACTERIA

9. EDUCATIONALACTIVITIES TO PROMOTE APPROPRIATE USE OF
ANTIMICROBIALAGENTS IN ANIMAL HEALTH
• Veterinary Curriculum
• State-based Interventions

10. Strategy of Containment
Antibiotic Resistance
Evolutionary
Process
Faulty Use of
Antibiotics
Hospital Environmental
Empirical Use Definitive Use
Community Acquired
Antibiotic Resistance
Hospital Acquired
Antibiotic Resistance
Use of antimicrobials before
pathogen responsible for a particular
illness or the susceptibility to a
particular antimicrobial is known

11. HOW THE COMPLEXITY
OF THE RESISTANCE PROBLEM DEDUCED
Do not use Faulty Antimicrobial Antimicrobial warranted or not

12. What are etiological agents? Definitive treatment

13. One OR In combination What can we do?