Get the right bispecific antibody as per your requirements. Creative Biolabs will perform the most suitable approach to fulfill your demands. Our team successfully produced all three types of bispecific antibodies using well-established methods.

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Professionals never cease their interests in studying bi-specific antibody. How much of you know about
bispecific antibodies? These are bioengineered antibodies that contain two different binding sites within a
single molecule, which can specifically bind two different types of antigen.
The most widely used application of bi-specific antibody is in cancer immunotherapy, which creates a
therapeutic treatment approach for diseases with specific medical needs.

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Compared with traditional antibodies, bispecific antibodies
have many advantages. The two arms can bring an antigen-
expressing cell in close proximity to a killing cell and thus
destroy the tumor cell; the two binding sites can significantly
increase affinity or internalization rates of particular antigens
on a cell's surface by binding to two different epitopes on an
antigen; they usually have a higher cytotoxic potential to
bind to antigens with low expression level. Binding tumor
cells using a bi-specific antibody-drug conjugate (ADC) also
holds great promise for the future development of
therapeutics for a variety of diseases.

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With the development of antibody engineering, many types of
bispecific antibodies have been designed to enable short half-
life, immunogenicity and side-effects caused by cytokine
liberation. They include tri-functional antibodies, chemically
linked Fabs, and various types of bivalent and trivalent single-
chain variable fragments (scFvs), fusion proteins mimicking the
variable domains of two antibodies. The furthest developed of
these newer formats are the bi-specific T-cell engagers (BiTEs)
and mAb2's, antibodies engineered to contain an Fcab antigen-
binding fragment instead of the Fc constant region.

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As a leader in the field of antibody engineering, Creative
Biolabs has developed CeativeAbTM antibodies in order to
increase the efficacy of current therapeutic antibodies.
Various Types of bispecific antibodies Creative Biolabs offers:
 Tri-functional antibodies and chemically linked Fabs
 Bivalent,and Bispecific scFvs (tandem scFv, diabodies)
 Bi-specific T-cell engagers (BiTEs)
 scFv-Fab Fusion Proteins

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Based on various antibody formats such as IgGs, Fabs and
scFvs, Creative Discovery PlatformTM of Creative Biolabs
provides a series of bispecific antibodies to satisfy various
needs from its customers. It provides construction, including
expression and purification as well as recombinant antibody
production at scales, ranging from hundreds of micrograms
to grams level.
By visiting Creative Biolabs, you can learn more about
bispecific antibody.