Chitosan (2-amino-2deoxy-(1β4)-Ξ²-D-glucopyranan), a polyaminosaccharide, normally obtained by alkaline deacetylation of chitin is the principal component of living organisms such as fungi and crustacea.
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Chitosan
1. Mr. Sagar Kishor savale
Department of Pharmaceutics
avengersagar16@gmail.com
2015-2016
Mr. Sagar Kishor savale
Department of Pharmaceutics
avengersagar16@gmail.com
2015-2016
Department of Pharmacy (Pharmaceutics)Department of Pharmacy (Pharmaceutics) || Sagar savaleSagar savaleDepartment of Pharmacy (Pharmaceutics)Department of Pharmacy (Pharmaceutics) || Sagar savaleSagar savale
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2. ο Chitosan (2-amino-2deoxy-(1 4)- -D-β Ξ²
glucopyranan), a polyaminosaccharide,
normally obtained by alkaline deacetylation
of chitin is the principal component of living
organisms such as fungi and crustacea.
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3. The degree of N-acetylation (DA) together with
the molecular weight are the most important
parameters for its characterization. The DA,
which is by definition the molar fraction of N-
acetylated units, is a structural parameter
influencing charge density, crystallinity and
solubility, including the propensity to
enzymatic degradation, with higher DAs
leading to faster biodegradation rates
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4. 1) Biocompatibility
2) Nonantigenicity
3) Nontoxicity (Its Degradation Products Are Known
Natural Metabolites)
4) The Ability To Improve Wound Healing/Or Clot
Blood
5) The Ability To Absorb Liquids And To Form
Protective Films And Coatings
6) Selective Binding Of Acidic Liquids,Thereby
Lowering Serum Cholesterol Levels.
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5. ο It is cationic polyamide
ο Chitosan reacts chemically with anionic system
ο It undergoes reactions typical of amines
(For ex. N-acetylation & Schiff reaction)
ο Acidity-Alkalinity:
PH= 4.0-6.0
ο Density: 1.35-1.40 g/cm3
ο Glass transition temperature: 2030
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6. ο Moisture content:
- It absorbs moisture from atmosphere
- Particle size distribution: <30 mm
ο Solubility:
- Sparingly soluble in water
- Practically insoluble in ethanol and other organic solvents
- Solubility is affected by degree of deacetylation
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7. ο Viscosity:
- The viscosity of chitosan increases with
increasing chitosan concentration, decreasing
temperature, and increasing degree of
deacetylation.
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8. ο Preparation of microspheres
ο Taste marked by spray drying
ο Preliminary study on film dosage form
prepared from chitosan for oral drug delivery
ο Increased stability of drug
ο Solubility increases as well as taste masking
ο Orthopaedic patient
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9. ο Cosmetic industry
ο Dental medicine
ο Enhanced bone formation by transforming
growth factor
ο Cholesterol lowering effect
ο Chitosan as a permiation enhancer
ο Chitosan as mucoadhesive excipient
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10. ο Aloe Vera Toothpaste
ο Opthalmic drug delivery
ο Gene delivery
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