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“Just a few days . . . Ebola, Zaire, 1976”

          Joel Breman, MD, DTPH
              Fogarty International Center
              National Institutes of Health


           50th Anniversary Celebration

           Epidemic Intelligence Service
     Centers for Disease Control and Prevention


               Atlanta, April 22, 2001
International Commission for the Investigation and
        Control of Ebola Hemorrhagic Fever

 Democratic Republic of the Congo (Zaire), 1976-77

                   Collaborators
                       Belgium
       Democratic Republic of the Congo (Zaire)
                       Canada
                       France
                    South Africa
                    United States
              World Health Organization
International Commission for the Investigation and
                Control of EHF 1976-77
Centers for Disease Control and Prevention Participation
                             Task Force Backup, Atlanta
  In DR Congo (Zaire)
                             John Bryan, EIS 1968
  Joel Breman, EIS 1976
                             Lyle Conrad, EIS 1965
  Stan Foster, EIS, 1962
                             Bill Foege, EIS 1971
  David Heymann, EIS 1976
                             Larry Schonberger, EIS 1971
  Karl Johnson
                             David Sencer, EIS 1975
  Joe McCormick, EIS 1973
                             Phil Brachman, EIS 1954
  Michael White, EIS 1975
                                 Laboratory, CDC
                                 Luanne Elliot
   In Sudan                      Jim Lange
                                 Fred Murphy
   Don Francis, EIS 1971
                                 Pat Webb
                                 Herta Wulff
Ebola, Zaire, 1976
                       Spectrum of Emotion and Activity
     Highest                                                  Less high
                                 Anxiety
                    Confidence
Emotion




                                  Uncertainty     Anger
                       (false)                                Celebration
             Terror
                             Sorrow    Understanding
                                                     Comfort
                  Fear
                                                      (false)
 Activity




             People                                     Active case
             fleeing           Rapid         Patient    detection
                     Chaos
                               Surveillance management
            Commissio                                         Plasmapheresis
            n formed   Isolation and Investigations/ Field
                       quarantine      quick         Investigations


          Low
                              Information Sharing
                                                                 High
Ebola Hemorrhagic Fever, DR Congo (Zaire), 1976:
         Team Members, Antwerp, 1996
Number of Cases of Ebola Hemorrhagic Fever in the
Equator Region, by Day of Onset and Probable Type of
    50           Transmission, 1976
    45                           Probable Type of
                                 Transmission
    40
                                      Person to Person
    35                                Both
 Cases




    30                                Syringe
         25

         20

         15

         10

         5

              1-3   4-6   7-9   10-12 13-15 16-18   19-21 22-24 25-27 28-30   1-3   4-6   7-9   10-12 13-15 16-18 19-21 22-24   25-27 28-30


                            September                                                           October
Ebola Virus, Zaire, 1976




Unfixed diagnostic specimen from
 Vero cell passage: sodium
phosphotungstate x 90,000
    (Fred Murphy)
Laboratory in Yambuku, DR Congo
                                 (Zaire), 1976




Guido van der Groen
Epidemiologists in Yambuku, DR Congo
              (Zaire), 1976




Peace Corps Volunteer, Joel Breman, Peter Piot, Pierre Sureau
Convalescent EHF Patient Undergoing
 Plasmapheresis, Yambuku, DR Congo (Zaire), 1976




Karl Johnson
Ebola Hemorrhagic Fever Team in
Yambuku, DR Congo (Zaire), 1976
Evacuation of EHF Commission Member from
Yambuku, DR Congo (Zaire), to Johannesburg,
              November 1976
Ebola Virus
Marburg Virus
Both
Marburg and Ebola Virus Outbreaks from 1967-2000
             The Filoviral Triangle




                                        Ebola Virus

                                        Marburg virus

                                        Both
Locations of Outbreaks of Ebola Hemorrhagic Fever, Sudan
 and DR Congo (Zaire), 1976, and DR Congo (Zaire), 1995
Time of Onset of Ebola Hemorrhagic Fever by
Transmission Type (after initial contact with source)
             DR Congo (Zaire), 1976
Flying along the Zaire River to Yambuku, DR
        Congo (Zaire), October 1976
Villages on the Bumba to Yambuku Road, DR
         Congo (Zaire), October 1976
Patient with Ebola Hemorrhagic Fever, Bumba Zone,
Equateur Province, DR Congo (Zaire), October 1976
Patient with Ebola Hemorrhagic Fever, Bumba Zone,
Equateur Province, DR Congo (Zaire), October 1976

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“Just a few days . . . Ebola, Zaire, 1976”

  • 1. “Just a few days . . . Ebola, Zaire, 1976” Joel Breman, MD, DTPH Fogarty International Center National Institutes of Health 50th Anniversary Celebration Epidemic Intelligence Service Centers for Disease Control and Prevention Atlanta, April 22, 2001
  • 2. International Commission for the Investigation and Control of Ebola Hemorrhagic Fever Democratic Republic of the Congo (Zaire), 1976-77 Collaborators Belgium Democratic Republic of the Congo (Zaire) Canada France South Africa United States World Health Organization
  • 3. International Commission for the Investigation and Control of EHF 1976-77 Centers for Disease Control and Prevention Participation Task Force Backup, Atlanta In DR Congo (Zaire) John Bryan, EIS 1968 Joel Breman, EIS 1976 Lyle Conrad, EIS 1965 Stan Foster, EIS, 1962 Bill Foege, EIS 1971 David Heymann, EIS 1976 Larry Schonberger, EIS 1971 Karl Johnson David Sencer, EIS 1975 Joe McCormick, EIS 1973 Phil Brachman, EIS 1954 Michael White, EIS 1975 Laboratory, CDC Luanne Elliot In Sudan Jim Lange Fred Murphy Don Francis, EIS 1971 Pat Webb Herta Wulff
  • 4. Ebola, Zaire, 1976 Spectrum of Emotion and Activity Highest Less high Anxiety Confidence Emotion Uncertainty Anger (false) Celebration Terror Sorrow Understanding Comfort Fear (false) Activity People Active case fleeing Rapid Patient detection Chaos Surveillance management Commissio Plasmapheresis n formed Isolation and Investigations/ Field quarantine quick Investigations Low Information Sharing High
  • 5. Ebola Hemorrhagic Fever, DR Congo (Zaire), 1976: Team Members, Antwerp, 1996
  • 6. Number of Cases of Ebola Hemorrhagic Fever in the Equator Region, by Day of Onset and Probable Type of 50 Transmission, 1976 45 Probable Type of Transmission 40 Person to Person 35 Both Cases 30 Syringe 25 20 15 10 5 1-3 4-6 7-9 10-12 13-15 16-18 19-21 22-24 25-27 28-30 1-3 4-6 7-9 10-12 13-15 16-18 19-21 22-24 25-27 28-30 September October
  • 7. Ebola Virus, Zaire, 1976 Unfixed diagnostic specimen from Vero cell passage: sodium phosphotungstate x 90,000 (Fred Murphy)
  • 8. Laboratory in Yambuku, DR Congo (Zaire), 1976 Guido van der Groen
  • 9. Epidemiologists in Yambuku, DR Congo (Zaire), 1976 Peace Corps Volunteer, Joel Breman, Peter Piot, Pierre Sureau
  • 10. Convalescent EHF Patient Undergoing Plasmapheresis, Yambuku, DR Congo (Zaire), 1976 Karl Johnson
  • 11. Ebola Hemorrhagic Fever Team in Yambuku, DR Congo (Zaire), 1976
  • 12. Evacuation of EHF Commission Member from Yambuku, DR Congo (Zaire), to Johannesburg, November 1976
  • 13.
  • 14.
  • 15.
  • 17. Marburg and Ebola Virus Outbreaks from 1967-2000 The Filoviral Triangle Ebola Virus Marburg virus Both
  • 18.
  • 19. Locations of Outbreaks of Ebola Hemorrhagic Fever, Sudan and DR Congo (Zaire), 1976, and DR Congo (Zaire), 1995
  • 20. Time of Onset of Ebola Hemorrhagic Fever by Transmission Type (after initial contact with source) DR Congo (Zaire), 1976
  • 21. Flying along the Zaire River to Yambuku, DR Congo (Zaire), October 1976
  • 22. Villages on the Bumba to Yambuku Road, DR Congo (Zaire), October 1976
  • 23. Patient with Ebola Hemorrhagic Fever, Bumba Zone, Equateur Province, DR Congo (Zaire), October 1976
  • 24. Patient with Ebola Hemorrhagic Fever, Bumba Zone, Equateur Province, DR Congo (Zaire), October 1976