SlideShare a Scribd company logo
1 of 15
Schistosoma (blood fluke)
life cycle
Shistosoma adult
Separate Sex
Oral and ventral sucker are little distance apart
Mouth, esophageus ,2 intestinal caeca
They reunion to form single caecum
Male is flattened , folded itself to form Gynaecophoric canal
Testes lies behind ventral sucker
Ovary : is ovoid ,lies infront of the union of caeca
Oviduct proceeds anteriorly it dilates to join ootype
Uterus : proceeds from ootype to open by vagina in the
Genital pore
Vitelline glands : are on either sides of the single caecum
Vitelline duct open in the ootype
schistosoma male
S. Haematobium
Larger 10×1 mm
Cuticle covered with fine tubercles
Union of caeca in the posterior half ( 2/3 + 1/3 )
Testes are 3-5 (4), large , globular and arranged in line .
S.Mansoni
Smaller 8×1 mm
Cuticle covered with coarse tubercles
Union of caeca in the anterior half ( 1/3 + 2/3 )
Testes are 6-9 (8),small,oval and overlapping in cluster .
Schistosoma haematobium adult male
Size: 10×1 mm
Cuticle covered with fine tubercles
Union of caeca:
in the posterior half ( 2/3 + 1/3 )
Testes:
are 3-5 (4), large , globular and
arranged in line .
Shistosoma female
S.Haematobium
Long and slender (20×0.25 mm ) ,cyliderical
Union of caeca in the posterior half like male
Ovary : oval,infront of the intestinal union (posteriorly )
Uterus : long,straight,containing 20 to 30 ova
Vitelline glands : small , extend along the single caecum
S. Mansoni
Smaller (14×0.15 mm)
Union of caeca in the anterior half like male
Ovary : in front of the intestinal caeca union (anteriorly)
Uterus : short ,contain 1 to 4 ova
Vitelline gland : larger
Male and female in copula
Slender female lies in the gynecological
Canal of the folded male
Species can be determined by number
Of testes in male and position of ovary
In female
Schistosoma egg
Size : 150× 65 µ ( S. mansoni ) & 140×60 µ (S. haematobium )
Shape: oval
Shell : thin
Colour : translucent , colourless
Content : mature miracidium
Ch.ch :
s.haematobium
s.Mansoni
Schistosoma haematobium egg
Size : 140×60 µ
Shape: oval
Shell : thin
Colour : translucent , colourless
Content : mature miracidium
Ch.ch : terminal spine
Shistosoma cercaria
(furcocercous cercaria)
Formed of body and tail
Body : 2 suckers, primitive gut ,
5-6 pairs of penetration glans
Tail : forked
Bulinus trancatus snail
- Left-sided snail
- Short spire.
- With shoulders and umbilicus.
- Deep sutures.
- Blunt apex and wide apex angle.
Good luck

More Related Content

Similar to renal module 2022.pdf

Scortal Ultrasound
Scortal UltrasoundScortal Ultrasound
Scortal UltrasoundDouble M
 
Trematodes kb
Trematodes kbTrematodes kb
Trematodes kbdotadota
 
prostatectomy with urinary incontinence-1 (1).pdf
prostatectomy with urinary incontinence-1 (1).pdfprostatectomy with urinary incontinence-1 (1).pdf
prostatectomy with urinary incontinence-1 (1).pdfMostafaAhmed891986
 
Prostate Anatomy,physiology & Pathology
Prostate Anatomy,physiology & PathologyProstate Anatomy,physiology & Pathology
Prostate Anatomy,physiology & PathologyFaisal Azmi
 
Schistosomiasis dr.rafal
Schistosomiasis dr.rafalSchistosomiasis dr.rafal
Schistosomiasis dr.rafalPH Moon
 
Male reproductive system of fasciola hepatica
Male reproductive system of fasciola hepaticaMale reproductive system of fasciola hepatica
Male reproductive system of fasciola hepaticaNarendra Manwar
 
Testicular tumor imaging
Testicular tumor imaging Testicular tumor imaging
Testicular tumor imaging Bom BC
 
Anatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsAnatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsDrGovindNarayanPuroh
 
Anatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsAnatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsDrGovindNarayanPuroh
 
Anatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsAnatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsDrGovindNarayanPuroh
 
testis presentation.pptx by dr. shahariar hossain
testis presentation.pptx by dr. shahariar hossaintestis presentation.pptx by dr. shahariar hossain
testis presentation.pptx by dr. shahariar hossainshahariarhossainshaw
 
Cancer and its types
Cancer and its typesCancer and its types
Cancer and its typesHabiba Arain
 
Benign ovarian Neoplasms Dr.H.K.Cheema-Professor-OBG.PIMS,Jalandhar
Benign ovarian Neoplasms   Dr.H.K.Cheema-Professor-OBG.PIMS,JalandharBenign ovarian Neoplasms   Dr.H.K.Cheema-Professor-OBG.PIMS,Jalandhar
Benign ovarian Neoplasms Dr.H.K.Cheema-Professor-OBG.PIMS,JalandharDr H.K. Cheema
 
Ovary Each ovary is whitish in colour and located alongside the la.pdf
Ovary  Each ovary is whitish in colour and located alongside the la.pdfOvary  Each ovary is whitish in colour and located alongside the la.pdf
Ovary Each ovary is whitish in colour and located alongside the la.pdfanyacarpets
 
diseases of the ovary.pptx
diseases of the ovary.pptxdiseases of the ovary.pptx
diseases of the ovary.pptxbashirlone123
 

Similar to renal module 2022.pdf (20)

Scortal Ultrasound
Scortal UltrasoundScortal Ultrasound
Scortal Ultrasound
 
Trematodes kb
Trematodes kbTrematodes kb
Trematodes kb
 
prostatectomy with urinary incontinence-1 (1).pdf
prostatectomy with urinary incontinence-1 (1).pdfprostatectomy with urinary incontinence-1 (1).pdf
prostatectomy with urinary incontinence-1 (1).pdf
 
Ovarian tumors
Ovarian tumorsOvarian tumors
Ovarian tumors
 
Class Trematoda.pptx
Class Trematoda.pptxClass Trematoda.pptx
Class Trematoda.pptx
 
Prostate Anatomy,physiology & Pathology
Prostate Anatomy,physiology & PathologyProstate Anatomy,physiology & Pathology
Prostate Anatomy,physiology & Pathology
 
Schistosomiasis dr.rafal
Schistosomiasis dr.rafalSchistosomiasis dr.rafal
Schistosomiasis dr.rafal
 
Male genital part i
Male genital part iMale genital part i
Male genital part i
 
Breast
BreastBreast
Breast
 
Male reproductive system of fasciola hepatica
Male reproductive system of fasciola hepaticaMale reproductive system of fasciola hepatica
Male reproductive system of fasciola hepatica
 
Testicular tumor imaging
Testicular tumor imaging Testicular tumor imaging
Testicular tumor imaging
 
Anatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsAnatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animals
 
Anatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsAnatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animals
 
Anatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animalsAnatomy of female reproductive organs in domestic animals
Anatomy of female reproductive organs in domestic animals
 
testis presentation.pptx by dr. shahariar hossain
testis presentation.pptx by dr. shahariar hossaintestis presentation.pptx by dr. shahariar hossain
testis presentation.pptx by dr. shahariar hossain
 
Laboratory diagnosis of Taenia species
Laboratory diagnosis of Taenia speciesLaboratory diagnosis of Taenia species
Laboratory diagnosis of Taenia species
 
Cancer and its types
Cancer and its typesCancer and its types
Cancer and its types
 
Benign ovarian Neoplasms Dr.H.K.Cheema-Professor-OBG.PIMS,Jalandhar
Benign ovarian Neoplasms   Dr.H.K.Cheema-Professor-OBG.PIMS,JalandharBenign ovarian Neoplasms   Dr.H.K.Cheema-Professor-OBG.PIMS,Jalandhar
Benign ovarian Neoplasms Dr.H.K.Cheema-Professor-OBG.PIMS,Jalandhar
 
Ovary Each ovary is whitish in colour and located alongside the la.pdf
Ovary  Each ovary is whitish in colour and located alongside the la.pdfOvary  Each ovary is whitish in colour and located alongside the la.pdf
Ovary Each ovary is whitish in colour and located alongside the la.pdf
 
diseases of the ovary.pptx
diseases of the ovary.pptxdiseases of the ovary.pptx
diseases of the ovary.pptx
 

More from mohammed abdelmoneim

More from mohammed abdelmoneim (9)

Practical slides 2020 for 1st grade students
Practical slides 2020 for 1st grade studentsPractical slides 2020 for 1st grade students
Practical slides 2020 for 1st grade students
 
Parasitology practical revision schemes 2020
Parasitology practical revision schemes 2020Parasitology practical revision schemes 2020
Parasitology practical revision schemes 2020
 
Parasitology slides 2020 kfs
Parasitology slides 2020 kfsParasitology slides 2020 kfs
Parasitology slides 2020 kfs
 
practical Arthropods 3
 practical Arthropods 3 practical Arthropods 3
practical Arthropods 3
 
practical arthropods part 2
practical  arthropods part  2practical  arthropods part  2
practical arthropods part 2
 
Plasmodium
PlasmodiumPlasmodium
Plasmodium
 
Toxoplasma gondii
Toxoplasma gondiiToxoplasma gondii
Toxoplasma gondii
 
Arthropods 1
Arthropods 1Arthropods 1
Arthropods 1
 
Trypansoma cruzi
Trypansoma cruziTrypansoma cruzi
Trypansoma cruzi
 

Recently uploaded

Stl Algorithms in C++ jjjjjjjjjjjjjjjjjj
Stl Algorithms in C++ jjjjjjjjjjjjjjjjjjStl Algorithms in C++ jjjjjjjjjjjjjjjjjj
Stl Algorithms in C++ jjjjjjjjjjjjjjjjjjMohammed Sikander
 
SURVEY I created for uni project research
SURVEY I created for uni project researchSURVEY I created for uni project research
SURVEY I created for uni project researchCaitlinCummins3
 
UChicago CMSC 23320 - The Best Commit Messages of 2024
UChicago CMSC 23320 - The Best Commit Messages of 2024UChicago CMSC 23320 - The Best Commit Messages of 2024
UChicago CMSC 23320 - The Best Commit Messages of 2024Borja Sotomayor
 
Analyzing and resolving a communication crisis in Dhaka textiles LTD.pptx
Analyzing and resolving a communication crisis in Dhaka textiles LTD.pptxAnalyzing and resolving a communication crisis in Dhaka textiles LTD.pptx
Analyzing and resolving a communication crisis in Dhaka textiles LTD.pptxLimon Prince
 
Trauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical PrinciplesTrauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical PrinciplesPooky Knightsmith
 
Đề tieng anh thpt 2024 danh cho cac ban hoc sinh
Đề tieng anh thpt 2024 danh cho cac ban hoc sinhĐề tieng anh thpt 2024 danh cho cac ban hoc sinh
Đề tieng anh thpt 2024 danh cho cac ban hoc sinhleson0603
 
PSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptxPSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptxMarlene Maheu
 
The Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDFThe Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDFVivekanand Anglo Vedic Academy
 
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...Nguyen Thanh Tu Collection
 
male presentation...pdf.................
male presentation...pdf.................male presentation...pdf.................
male presentation...pdf.................MirzaAbrarBaig5
 
Sternal Fractures & Dislocations - EMGuidewire Radiology Reading Room
Sternal Fractures & Dislocations - EMGuidewire Radiology Reading RoomSternal Fractures & Dislocations - EMGuidewire Radiology Reading Room
Sternal Fractures & Dislocations - EMGuidewire Radiology Reading RoomSean M. Fox
 
When Quality Assurance Meets Innovation in Higher Education - Report launch w...
When Quality Assurance Meets Innovation in Higher Education - Report launch w...When Quality Assurance Meets Innovation in Higher Education - Report launch w...
When Quality Assurance Meets Innovation in Higher Education - Report launch w...Gary Wood
 
ANTI PARKISON DRUGS.pptx
ANTI         PARKISON          DRUGS.pptxANTI         PARKISON          DRUGS.pptx
ANTI PARKISON DRUGS.pptxPoojaSen20
 
diagnosting testing bsc 2nd sem.pptx....
diagnosting testing bsc 2nd sem.pptx....diagnosting testing bsc 2nd sem.pptx....
diagnosting testing bsc 2nd sem.pptx....Ritu480198
 
FICTIONAL SALESMAN/SALESMAN SNSW 2024.pdf
FICTIONAL SALESMAN/SALESMAN SNSW 2024.pdfFICTIONAL SALESMAN/SALESMAN SNSW 2024.pdf
FICTIONAL SALESMAN/SALESMAN SNSW 2024.pdfPondicherry University
 
How to Manage Website in Odoo 17 Studio App.pptx
How to Manage Website in Odoo 17 Studio App.pptxHow to Manage Website in Odoo 17 Studio App.pptx
How to Manage Website in Odoo 17 Studio App.pptxCeline George
 
Personalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes GuàrdiaPersonalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes GuàrdiaEADTU
 
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...Nguyen Thanh Tu Collection
 

Recently uploaded (20)

ESSENTIAL of (CS/IT/IS) class 07 (Networks)
ESSENTIAL of (CS/IT/IS) class 07 (Networks)ESSENTIAL of (CS/IT/IS) class 07 (Networks)
ESSENTIAL of (CS/IT/IS) class 07 (Networks)
 
Stl Algorithms in C++ jjjjjjjjjjjjjjjjjj
Stl Algorithms in C++ jjjjjjjjjjjjjjjjjjStl Algorithms in C++ jjjjjjjjjjjjjjjjjj
Stl Algorithms in C++ jjjjjjjjjjjjjjjjjj
 
SURVEY I created for uni project research
SURVEY I created for uni project researchSURVEY I created for uni project research
SURVEY I created for uni project research
 
UChicago CMSC 23320 - The Best Commit Messages of 2024
UChicago CMSC 23320 - The Best Commit Messages of 2024UChicago CMSC 23320 - The Best Commit Messages of 2024
UChicago CMSC 23320 - The Best Commit Messages of 2024
 
Analyzing and resolving a communication crisis in Dhaka textiles LTD.pptx
Analyzing and resolving a communication crisis in Dhaka textiles LTD.pptxAnalyzing and resolving a communication crisis in Dhaka textiles LTD.pptx
Analyzing and resolving a communication crisis in Dhaka textiles LTD.pptx
 
Trauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical PrinciplesTrauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical Principles
 
Đề tieng anh thpt 2024 danh cho cac ban hoc sinh
Đề tieng anh thpt 2024 danh cho cac ban hoc sinhĐề tieng anh thpt 2024 danh cho cac ban hoc sinh
Đề tieng anh thpt 2024 danh cho cac ban hoc sinh
 
PSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptxPSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptx
 
The Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDFThe Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDF
 
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
 
male presentation...pdf.................
male presentation...pdf.................male presentation...pdf.................
male presentation...pdf.................
 
Sternal Fractures & Dislocations - EMGuidewire Radiology Reading Room
Sternal Fractures & Dislocations - EMGuidewire Radiology Reading RoomSternal Fractures & Dislocations - EMGuidewire Radiology Reading Room
Sternal Fractures & Dislocations - EMGuidewire Radiology Reading Room
 
When Quality Assurance Meets Innovation in Higher Education - Report launch w...
When Quality Assurance Meets Innovation in Higher Education - Report launch w...When Quality Assurance Meets Innovation in Higher Education - Report launch w...
When Quality Assurance Meets Innovation in Higher Education - Report launch w...
 
ANTI PARKISON DRUGS.pptx
ANTI         PARKISON          DRUGS.pptxANTI         PARKISON          DRUGS.pptx
ANTI PARKISON DRUGS.pptx
 
diagnosting testing bsc 2nd sem.pptx....
diagnosting testing bsc 2nd sem.pptx....diagnosting testing bsc 2nd sem.pptx....
diagnosting testing bsc 2nd sem.pptx....
 
FICTIONAL SALESMAN/SALESMAN SNSW 2024.pdf
FICTIONAL SALESMAN/SALESMAN SNSW 2024.pdfFICTIONAL SALESMAN/SALESMAN SNSW 2024.pdf
FICTIONAL SALESMAN/SALESMAN SNSW 2024.pdf
 
How to Manage Website in Odoo 17 Studio App.pptx
How to Manage Website in Odoo 17 Studio App.pptxHow to Manage Website in Odoo 17 Studio App.pptx
How to Manage Website in Odoo 17 Studio App.pptx
 
Personalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes GuàrdiaPersonalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes Guàrdia
 
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
 
OS-operating systems- ch05 (CPU Scheduling) ...
OS-operating systems- ch05 (CPU Scheduling) ...OS-operating systems- ch05 (CPU Scheduling) ...
OS-operating systems- ch05 (CPU Scheduling) ...
 

renal module 2022.pdf

  • 1.
  • 3. Shistosoma adult Separate Sex Oral and ventral sucker are little distance apart Mouth, esophageus ,2 intestinal caeca They reunion to form single caecum Male is flattened , folded itself to form Gynaecophoric canal Testes lies behind ventral sucker Ovary : is ovoid ,lies infront of the union of caeca Oviduct proceeds anteriorly it dilates to join ootype Uterus : proceeds from ootype to open by vagina in the Genital pore Vitelline glands : are on either sides of the single caecum Vitelline duct open in the ootype
  • 4. schistosoma male S. Haematobium Larger 10×1 mm Cuticle covered with fine tubercles Union of caeca in the posterior half ( 2/3 + 1/3 ) Testes are 3-5 (4), large , globular and arranged in line . S.Mansoni Smaller 8×1 mm Cuticle covered with coarse tubercles Union of caeca in the anterior half ( 1/3 + 2/3 ) Testes are 6-9 (8),small,oval and overlapping in cluster .
  • 5. Schistosoma haematobium adult male Size: 10×1 mm Cuticle covered with fine tubercles Union of caeca: in the posterior half ( 2/3 + 1/3 ) Testes: are 3-5 (4), large , globular and arranged in line .
  • 6. Shistosoma female S.Haematobium Long and slender (20×0.25 mm ) ,cyliderical Union of caeca in the posterior half like male Ovary : oval,infront of the intestinal union (posteriorly ) Uterus : long,straight,containing 20 to 30 ova Vitelline glands : small , extend along the single caecum S. Mansoni Smaller (14×0.15 mm) Union of caeca in the anterior half like male Ovary : in front of the intestinal caeca union (anteriorly) Uterus : short ,contain 1 to 4 ova Vitelline gland : larger
  • 7.
  • 8. Male and female in copula Slender female lies in the gynecological Canal of the folded male Species can be determined by number Of testes in male and position of ovary In female
  • 9.
  • 10. Schistosoma egg Size : 150× 65 µ ( S. mansoni ) & 140×60 µ (S. haematobium ) Shape: oval Shell : thin Colour : translucent , colourless Content : mature miracidium Ch.ch : s.haematobium s.Mansoni
  • 11. Schistosoma haematobium egg Size : 140×60 µ Shape: oval Shell : thin Colour : translucent , colourless Content : mature miracidium Ch.ch : terminal spine
  • 12. Shistosoma cercaria (furcocercous cercaria) Formed of body and tail Body : 2 suckers, primitive gut , 5-6 pairs of penetration glans Tail : forked
  • 13.
  • 14. Bulinus trancatus snail - Left-sided snail - Short spire. - With shoulders and umbilicus. - Deep sutures. - Blunt apex and wide apex angle.