Putting Yeast to Work: Reducing Supply Chain Volatility

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Howard Fuller
Amyris
Vice President, Quality and
Supply Chain

Putting Yeast to Work:
Reducing Supply Chain
Volatility
Howard Fuller
Amyris
Vice President, Quality and Supply Chain

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 September 2016Supply Chain Insights Global Summit #Imagine2030
Agenda
 Introduction
 The Supply Chain Challenge
 The Supply Chain Opportunity
 Examples of Success
 Conclusion
 Q&A
Copyright © Amyris, Inc. All rights reserved

Introduction

What Inspires Us?
Industrial biotechnology delivering better
materials that make sourcing sustainable,
our planet happy.

Our Customer Promise…
Low cost
producer
High
performance
ingredients
Provide a
Reliable Supply
at a Stable Price
Sustainably
produced

Delivering on that Promise to +470 Brands

The Supply Chain Challenge

Volatility is the New Normal
Availability, Cost & Quality of Supply for Sourcing Chemicals
• Oil: Regional Unrest, natural disasters, etc.
• Crops: Drought, Floods, Pests, Food Challenges, etc.
• Ocean Harvesting: Collapsing Fish Stocks, Regulations, etc.

Volatility Due To Changing Market Views
What was acceptable yesterday, may not be tomorrow
• Removing natural resources can seen as exploitive
• Harvesting can be seen as excessive
• Processes such as chemical reactions, catalytic conversion
and cracking often utilize heavy metals and can be viewed
as generating unacceptable pollution / waste

The Supply Chain Opportunity

Delivering Reliable Supply, Lower Cost, Drive Growth
1 2 3
Plant/Animal sourced Petroleum sourced Diverse/difficult to
replicate
• Substituting out high Volatility sources found in Nature
• Eliminating complex mfg. chemistry (and the pollution/waste)
• Replacing difficult processes with easier ones
80% of
profits

How ?
1
Utilize synthetic
biology to create
yeast strains that
produce your
molecule
2
Utilize yeast strains
in industrial scale
fermentation to
produce your high
value chemicals

At What Scale?
• We can produce in excess of 1,250 MT / Mo
• Have run over 8 Molecules (4 in just one year)
• Delivering to our customer’s door high value
chemicals / ingredients
In just this plant…

How Fast?
BUILD
High Throughput
Screening
Automated
Strain
Engineering
Tens of KG
quantities
300 L
METRIC TON
quantities
200,000 L
GRAM
quantities
0.5L & 2L
+ PPS
TS
P450
100,000+
compounds
SCREEN SCALE UP
Using automation and proprietary processes to go from
concept to manufacturing in 12 months for most ingredients

Examples of Success

Delivering High Value Supply Across Multiple Markets
Pharmaceutical
s
Cosmetics
Currently supplied markets
Flavors & Fragrances
Polymers Solvents
Lubricants
Diesel
Adhesives &
Coatings
Jet Fuel
Selected Consumer Brands
Personal Care
Performance
Chemicals
Industrial

Putting Yeast to Work Thru Synthetic Biology
• Lubricants: offsets use of Oil,
• Cosmetics: offsets use of Olives / Shark livers with low bioavailability,
• Solvents: offsets use of Oil,
• Fragrances: offsets use of Plants and Laborious Harvests,
• Pharmaceuticals: offsets use of Plants with Low Bioavailability,
• Jet Fuel: offsets use of Oil and GHG emissions,
• Nutraceuticals: offsets use of Oil,
Significantly Improving Availability, Cost Stability AND Quality

Conclusion

What Chemicals in your Supply Chain would Benefit from
• A reliable, sustainable supply,
• Stable, competitive pricing,
• Exceptional quality,
That is good for our planet, good for consumers and good for business
Partnering with Amyris Can Transform Your Supply Chain!

Putting Yeast to Work: Reducing Supply Chain Volatility

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