Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst.

1. DIABETES
INSIPIDUS
1

2. DEFINITION
“Diabetes insipidus is the disorder of
the posterior pituitary gland that is
characterised by a deficiency of
Antidiuretic hormons”
It is mainly characterised exessive
thirst and large volume of dilute
urine.

3. CAUSES
• Any head trauma.
• Brain tumor.
• Surgical ablation or irradiation of the
pituatary gland.
• Infection of the central nervous system.
• Any tumor.
• Fialure of renal tubules to respond to
ADH.

4. PATHOPHYSIOLOGY
Due to any cause
Abnormalities of the posterior pituitary
gland
Deficient production of vasopresin

5. 1
Abnormally large volume of dilute urine
are excreted.
DIABETES INSIPIDUS

6. CLINICAL MENIFESTATION
• Polydipsia.
• Large volume of dilute urine excreted.
• Water like urine.
• Severe dehydration.
• Weight loss.
• Hypernatremia.

7. ASSESSMENT
• Physical examination.
• Sign and Symptoms.
• The Fluid Deprivation Test.
• Plasma and urine osmolarity study.
• SERUM Osmolarity.
• All Blood test.

8. MEDICAL MANAGEMENT
• Desmopressin.
• Intramuscular administration of ADH
• Clofibrate.-a hypolipidemic agent
• Chlorprapamide.-diabenese.
• Thiazide –diuretics.

9. 1
• If diabetes insipidus is renal in origin..
• -Thiazide.
• -Mild salt depletion.
• -Prostaglandin inhibitors.

10. THANK
YOU
• 1