DI

1. ‫امارت‬
‫اسالمی‬
‫افغانستان‬
‫وزارت‬
‫صحت‬
‫عامه‬
‫شفاخانه‬
‫تخصصی‬
‫پروان‬
‫دیپارتمنت‬
‫داخله‬
‫عمومی‬
‫دیابت‬
‫بی‬
‫مزه‬
‫تهیه‬
‫و‬
‫ترتیب‬ : ‫ناصر‬
‫ارمان‬

2. Contains
• Definition
• Types
• Causes
• Clinical manifestations
• Laboratory studies
• Deffrentiation diagnosis
• Treatment

3. Deffination
• Diabetes insipidus is a rare condition where you pee a lot and often
feel thirsty.

4. Types
• Cranial
• Nephrogenic

5. Cranial DI
• Primary DI
• Secondary DI
• Vasopressinase induced DI
• Tumors
• Surgery
• Trauma
• Radiation
• Infections
• Idiopathic
• Gestational DI

6. Nephrogenic DI
• V2 Receptors insufficiency
• Pyelonphritis
• Renal Amyloidosis
• Sickle cell anemia
• Chronic hypercalcemia
• Multipal Myeloma
• Drugs

7. Clinical manifestations
• Pollyurea
• Pollydepsia
• General Clinical manifestations

8. Laboratory Studies
• Testing urine to see if it contains too much water can be helpful in
identifying diabetes insipidus. Blood tests. Checking the levels of
certain substances in the blood, such as sodium, potassium and
calcium, can help with a diagnosis and may be useful in identifying
the type of diabetes insipidus

9. Differential diagnosis
• DM type 2
• Drug induced pollyurea

10. Treatment of cranial DI
• Desmopressin
• Lepressin
• Chlorpropamid
• Carbamazepin

11. Treatment of Nephrogenic DI
• Hydrochlorothiazide + Desmopressin
• Hydrochlorothiazide + Indomethacin

12. • Thanks