Image result for T cell deficiency T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it causes an immunodeficiency of cell-mediated immunity. T cells normal function is to help with the human body's immunity, they are one of the two primary types of lymphocytes

1. T CELL DEFFICIENCIES

2. • DEFECTS IN T CELLS LEAD TO
OPPORTUNISTIC INFECTIONS.
• GENETIC IN ORIGIN
• INCREASED SUSCEPTIBILITY TO
INFECTION
• S/S DEPENDS UPON THE TYPE OF
T CELLS AFFECTED

3. • 1. THYMIC HYPOPLASIA[
DIGEORGE SYNDROME]
• ABSENCE OF SEVERAL GENES
ON CHROMOSOME 22
• THYMUS GLAND FAILS TO
DEVELOP NORMALLY DURING
EMBRYOGENESIS
• SYMPTOMS PRESENT ALMOST
SOON AFTER BIRTH

4. • SIGN AND SYMPTOM
• HYPOTHYROIDISM WITH
HYPOCALCEMIA
• CONGENITAL HEART DISEASE
• RENAL ABNORMALITIES
• ABNORMAL FACES
• TETANY
• CONVULSIONS

5. • DIAGNOSIS
• T CELLS EVALUATION-
PERIPHERAL BLOOD
LYMPHOCYTE COUNT
• WILL FIND LYMPHOPENIA

6. • MANAGEMENT
• THYMUS TRANSPLANTATION
• HUMAN LEUKOCYTE ANTIGEN
MATCHED BONE MARROW TO THE
RECONSTITUTION OF
PERMANENT T CELL IMMUNITY

7. • 2. CHRONIC MUCOCUTANEOUS
CANDIDIASIS
• AUTOSOMAL RECESSIVE
INHERITANCE
• AUTOIMMUNE DISORDER IN
WHICH THE THYMUS AND OTHER
ENDOCRINE GLANDS ARE
INVOLVED IN AUTOIMMUNE
PROCESS
• EXTENSIVE MORBIDITY DUE TO

8. • S/S
• CHRONIC CANDIDAL INFECTION
• HYPOCALCEMIA
• TETANY SECONDARY TO THE
HYPOFUNCTION OF THE
PARATHYROID GLAND
• ADDISON’S DISEASE

9. • DIAGNOSIS IS DONE BY THE
DERMAL SENSITIZATION OF THE
PATIENT
•
• MANAGEMENT-
• ANTIFUNGAL AGENT
• IVIG