Class III malocclusion is characterized by the lower teeth occluding ahead of their normal position, with variations such as pseudo Class III and skeletal Class III based on factors like genetics and developmental deficiencies. The prevalence varies across different demographics, and treatment options range from functional appliances in pre-adolescents to face mask therapy for maxillary protraction, focusing on correcting skeletal disharmony. Indications for early treatment include good facial aesthetics and mild skeletal issues, while contraindications highlight the challenges associated with severe disharmony and completed growth.