This document provides guidance on developing a systematic and comprehensive search strategy for systematic reviews. It explains that a systematic search strategy is essential to capture all relevant studies on a topic. The strategy should include synonyms for key concepts, Boolean operators to combine terms, and subject headings from different databases. It provides an example of developing a search strategy based on turning a research question into PICO components and combining population, intervention, comparison, and outcome terms. The search strategy example spans multiple slides and databases to model a comprehensive approach.