GOOD PRSN

1. ALIGARH MUSLIM
UNIVERSITY
PRESENTED BY-
ANAM ANSARI

2. INTRODUCTION.
IONIC LIQUIDS: PREPARATION AND PROPERTIES.
SYNTHESIS AND APPLICATION OF:
 FURAN AND DERIVATIVES.
 PYRAN AND DERIVATIVES.
 COUMARINS AND
 DIOXANES.
APPLICATION OF IONIC LIQUIDS IN SYNTHESIS.
CONCLUSION.
REFERENCES.

3. Oxacycles are part of an extensive group of organic
structures which are used as a synthetic intermedia.
They are also important because of biological,
pharmacological and industrial value of some of the
structures in which they are present.
Most of the reaction media used in traditional chemistry
utilize volatile organic compounds which have several
disadvantages.
Room temperature ionic liquids were introduced as a
novel reaction media in synthesis of oxacyclic
derivatives.
Utilization of RTILs meant some improvement in
relation to reaction yield, reagents selectivity, and
diminution in the reaction time, recyclability, as well as
improvement in environmental condition.

4.  Ionic liquid is a salt in the liquid state.
 Largely made of ions and short-lived ion pairs.
 They are conductors of electricity, non-ionizing, highly viscous and
frequently exhibit low vapor pressure.
 They show:
 Low combustibility.
 Wide liquid range.
 Excellent thermal stability.
 Favorable solvating properties.
 They are used in:
 Organic Synthesis.
 Chemical Industry.
 Food and Bio products.
 Gas Handling.
 Waste Recycling.
 Pharmaceuticals.
 Dispersant.
 Batteries

5. IONIC LIQUIDS ARE PREPARED BY
METATHESIS OF HALIDE SALTS.

6. B:Butyl
m:Methyl
im:Imidazolium
[Bmim][BF4]

8. 1. SYNTHESIS OF FURAN IN Mn(oAc)3 AS CATALYST
AND [Bmim][BF4] AS REACTION MEDIUM
 GENERALLY SYNTHESISED BY 1, 4- DICARBONYL
COMPOUNDS OR
β-KETOESTER UNDER ACID CATALYSIS.

10. 2.SYNTHESIS WITH β-KETOESTERS WITH SAME
REACTION CONDITION

12. 3.SYNTHESIS OF BENZOFURAN IN Ln(OTf)3 AS
CATALYST IN IONIC LIQUID.
80-90%

13. SYNTHO
N
SOLVEN
T
INSECTI-
CIDE
FURAN
RESIN
PHARMA-
CEUTICAL
S

14. 1.SYNTHESIS OF PYRAN IN [Bmim][PF6]
70-80%

15. 2. MULTICOMPONENT SYNTHESIS IN
[Bmim][BF4]

16. S NO. SOLVENT TEMPERATURE
(0
C)
TIME (h) YIELD (%)
1 [Bmim][BF4] 80 0.5 98
2 EtOH Reflux 5 76
3 Toluene 80 5 75
4 THF Reflux 5 71
5 [Bmim][BF6] 80 1 90
6 [Bmim][BF4] 80 1 90
TABLE: SOLVENT AND REACTION CONDITIONS
FOR PYRAN DERIVATIVES SYNTHESIS

17. SYNTHON
ANTIFUNGAL
AGENTS
PHARMAC-
EUTICALS

18. 1.PECHMAN CONDENSATION IN [Bmim]Cl.2ALCl3

20. 2.SYNTHESIS OF BENZOCOUMARIN IN
[Bmim][Al2Cl7]

23. SYNTHESIS BY THE REACTION OF FORMALDEHYDE
AND STYRENE IN IONIC LIQUID.

25. DIOXANE
COSM-
ETICS
PHARMAC-
EUTICALS
SOLVENT

27. Use of RTILs introduces most significant advances in
synthesis of Oxacyclic derivatives.
From the simplest monooxacycles to most
polyoxacycles both are synthesized using RTILs.
The main effects reported by using ionic liquids were
the improvement of reaction yields and the reduction
of reaction time.
Other beneficial effects have been also reported when
used as supported for other media or reaction catalyst
such as silica gel and in microwave assisted synthesis.
RTILs are eco-friendly reaction media and help to
reduce pollution.

28.  CURRENT ORGANIC SYNTHESIS, 2012, 9, 65-73. MARTA TEIJEIRA AND
MORALES-HELGUERA.
 CHEMICAL COMMUNICATION, 2001, 1350-1351. PARSON AND THOMAS.
 JOURNAL OF ORGANIC CHEMISTRY, 2003, 68,4406-4409.
 TETRAHEDRON LETT. 2004, 45, 5873-5876.
 TETRAHEDRON LETT. 2003, 59, 1599-1604.
 TETRAHEDRON LETT. 2007, 48, 7926-7929.
 APPL.CATAL.A GEN. 2009, 363, 93-99.
 CATAL.COMMUNICATION.2005, 6, 57-60.
 TERAHEDRON LETT. 2005, 46, 3931-3933.
 BIOORG.MED.CHEM.LETT.2010, 20, 809-813.