Prions are viruses that cause proteins to misfold. Select one: True False Solution 12). FALSE Prion is an infectious agent completely made of a protein known as PrP, they are not viruses. Prions can fold in multiple ways to form different 3-D structures (means tertiary structure), which makes them resistant to many of the sterilization processes such as heat, UV light, formaldehyde and also resistant to proteases. Priones do not contain genetic material or capsid..