Hypothesize a way for a virus to evade a host defense & then devise an experiment with controls
to either prove or disprove.
Solution
Answer :
The immune system is one of an organism\'s most complex systems and shows many signs of
coevolution with parasites. It is well tuned to its task, as otherwise long-lived multicellular
organisms would probably not be able to survive and outpace their short-lived and numerous
parasites.
For example we consider the RHV in human beings which causes the common cold which is
earlier identified with the morphological and siymptoms caused in th human beings. The causal
organism has co evolved depending upon the antibiotics used to control the organism but it has
co evolved. To check the co evolution the follwing experiment can be conducted with
Polymerase chain reaction.
Intially the RHV samples i.e common cold samples were collected and the virus was isolated the
RNA from the organism from which the cDNA is synthesised and checked for the amplication
with primers designed for the vrulence genes of the organism. The control sample was prepared
from the sequnced strain of RHV then the test samples were subjected for PCR amplification.
The positive control sample gives a specific band whichis compared with the test samples. If the
same band gets amplifies then the strain is not changed or evolved but if there is any change in
the amplification then the strain have changed indicating the virulence has changed which may
result in loss of function or gain of function..
Hypothesize a way for a virus to evade a host defense & then devise .pdf
1. Hypothesize a way for a virus to evade a host defense & then devise an experiment with controls
to either prove or disprove.
Solution
Answer :
The immune system is one of an organism's most complex systems and shows many signs of
coevolution with parasites. It is well tuned to its task, as otherwise long-lived multicellular
organisms would probably not be able to survive and outpace their short-lived and numerous
parasites.
For example we consider the RHV in human beings which causes the common cold which is
earlier identified with the morphological and siymptoms caused in th human beings. The causal
organism has co evolved depending upon the antibiotics used to control the organism but it has
co evolved. To check the co evolution the follwing experiment can be conducted with
Polymerase chain reaction.
Intially the RHV samples i.e common cold samples were collected and the virus was isolated the
RNA from the organism from which the cDNA is synthesised and checked for the amplication
with primers designed for the vrulence genes of the organism. The control sample was prepared
from the sequnced strain of RHV then the test samples were subjected for PCR amplification.
The positive control sample gives a specific band whichis compared with the test samples. If the
same band gets amplifies then the strain is not changed or evolved but if there is any change in
the amplification then the strain have changed indicating the virulence has changed which may
result in loss of function or gain of function.
