CONCEPT OF RESPIRATORY CHAIN                 -ANUSHA SHARMA                          (@nu)
What is respiration? The act or process of inhaling and exhaling; breathing. Also called ventilation. The oxidative proc...
What does happen when respirationoccurs? The oxygen which is in taken in respiration . It  helps in the process of catabo...
Respiration chain The energy librated during the oxidation of food  molecules is made available with in  mitochondria as ...
 The passage of electrons in ETC is associated with the  loss of free energy ,this free energy is utilized to  generate A...
Components of respiration chain     The inner mitochondria membrane can be disrupted    into 5 distinct respiratory or en...
 And complex V is responsible for ATP synthesis Pyruvate and alpha –ketoglutarate dehydrogenase and feS are other compon...
Complex of ETC
Complex 1   Has NADH binding site     NADH reductase activity       NADH - NAD+     NADH ---> FMN--->FeS---> ubiquino...
Complex II   succinate ---FAD—ubiquinone     Contains coenzyme Q     FADH2 binding site         FAD reductase activity...
Complex III   ubiquinone - ubiquinone ox   while cyt C gets reduced   Also contains cytochromes b     proton pump 4H+...
Complex IV reduction of oxygen cytochrome oxidase cyt a+a3 red ---> oxidized state oxygen ---> water    2 H+ + 2 e- +...
Totals Proton gradient created as electrons transferred to oxygen forming water  10 H+ / NADH  6 H+ / FADH2
Complete mechanism
What is respiration
What is respiration
What is respiration
What is respiration
What is respiration
What is respiration
Upcoming SlideShare
Loading in …5
×

What is respiration

816 views

Published on

Published in: Education
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
816
On SlideShare
0
From Embeds
0
Number of Embeds
18
Actions
Shares
0
Downloads
12
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

What is respiration

  1. 1. CONCEPT OF RESPIRATORY CHAIN -ANUSHA SHARMA (@nu)
  2. 2. What is respiration? The act or process of inhaling and exhaling; breathing. Also called ventilation. The oxidative process occurring within living cells by which the chemical energy of organic molecules is released in a series of metabolic steps involving the consumption of oxygen and the liberation of carbon dioxide and water.
  3. 3. What does happen when respirationoccurs? The oxygen which is in taken in respiration . It helps in the process of catabolism Catabolism: complex food molecules to small particles and get converted to acetyl coA
  4. 4. Respiration chain The energy librated during the oxidation of food molecules is made available with in mitochondria as reducing equivalents (NADH and FADH2) Mitochondria contains the respiratory chain which collects and transport reducing equivalents directing them to their final reaction with oxygen to form water
  5. 5.  The passage of electrons in ETC is associated with the loss of free energy ,this free energy is utilized to generate ATP. this respiration chain occurs in the mitochondria in the inner membrane( matrix, Cristal )
  6. 6. Components of respiration chain The inner mitochondria membrane can be disrupted into 5 distinct respiratory or enzyme complex denoted as complex I, II, III, IV and V . . NADH-Q oxidoreductase, succinate-Q reductase, Q-cytochrome c oxidoreductase, and cytochrome c oxidase are also called Complex I, II, III, and IV, respectively
  7. 7.  And complex V is responsible for ATP synthesis Pyruvate and alpha –ketoglutarate dehydrogenase and feS are other components
  8. 8. Complex of ETC
  9. 9. Complex 1 Has NADH binding site  NADH reductase activity  NADH - NAD+  NADH ---> FMN--->FeS---> ubiquinone  ubiquinone ---> ubiquinone H2  4 H+ pumped/NADH
  10. 10. Complex II succinate ---FAD—ubiquinone  Contains coenzyme Q  FADH2 binding site  FAD reductase activity  FADH2 -- FAD
  11. 11. Complex III ubiquinone - ubiquinone ox while cyt C gets reduced Also contains cytochromes b  proton pump 4H+  Adds to gradient 8 H+ / NADH 4 H+ / FADH2
  12. 12. Complex IV reduction of oxygen cytochrome oxidase cyt a+a3 red ---> oxidized state oxygen ---> water  2 H+ + 2 e- + ½ O2 -- 2 H2O  transfers e- one at a time to oxygen Pumps 2H+ out  Total of 10 H+ / NADH  Total of 6 H+ / FADH2
  13. 13. Totals Proton gradient created as electrons transferred to oxygen forming water 10 H+ / NADH 6 H+ / FADH2
  14. 14. Complete mechanism

×